June 2, 2015 UChicago Medicine to lead $ 10 million March of Dimes Prematurity Research Center Collaboration with Northwestern University Feinberg School of Medicine, Duke University School of Medicine to
study gene regulation in normal, preterm pregnancies
This work is one basis for the use in the scientific community of transgenes as a major technique to
study gene regulation in normal and malignant cells.
To find answers to these questions, the scientists
studied the gene regulation of the DPP4 gene in mice that are prone to obesity.
«During the last few years, my laboratory has been immersed in
studying gene regulation,» Dr. Bazan says.
«It may have relevant implications for researchers worldwide
studying gene regulation in general since we know now that the large - scale organization of the genome can not be ignored.
The lab
studies gene regulation via multiple lines.
Not exact matches
Using blood samples, the
study found that
regulation of the oxytocin receptor
gene OXTR was associated with development of the condition.
But a new
study, published today in Nature, has revealed that m6A plays a key role in the
regulation of the Sex - lethal (Sxl)
gene, which controls sex determination of the fruit fly Drosophila.
Although the
regulation of this
gene has a strong «cell cycle control» component, I was more interested in
studying cell cycle
regulation «proper.»
For example, the
study found down -
regulation of
genes involved in interferon tau, the major signal of pregnancy recognition.
After having conducted a large - scale
study performed on cells from the umbilical cords of 204 newborns, the researchers from UNIGE demonstrate that DNA methylation may play both a passive and active role in
gene regulation.
Teaming up with her friend Xianlin, they
studied GADD45a, a
gene involved in cell growth
regulation.
The
study identified five
genes predictive of feeding success representing a range of biological systems: sensory integration (NPHP4, PLXNA1); hypothalamic
regulation, a region of the brain that plays a key role in hunger signaling (NPY2R); facial development (WNT3, a
gene associated with lip and palate development); and energy expenditure (AMPK, a regulator of whole body energy balance).
Booij and her colleagues hope that this
study will shed more light on the specific role of early environmental influences on brain development,
gene expression and emotional
regulation.
«Single
gene variation linked to obesity: Variation in the BDNF
gene may affect brain's
regulation of appetite,
study suggests.»
«Quantum machine shows promise for biological research: In first quantum machine learning
study with biological data, researchers leverage D - Wave to understand
gene regulation.»
«What is important in our
study is that we proved that there was a unique and consistent solution to the fitting problem, something that has never before been achieved for a realistic complex model of
gene regulation,» stated Dr. Jaeger.
The protein
studied in the mold is part of a larger family of proteins also found in humans and involved in many essential biological processes including
gene regulation and fatty acid metabolism.
In a
study recently published in the journal Neuro - Oncology, a team of scientists led by Luni Emdad, M.B.B.S., Ph.D., and Paul B. Fisher, M.Ph., Ph.D., provided the first evidence of an important link between a specific microRNA, miR - 184, and a cancer promoting
gene, SND1, in the
regulation of malignant glioma.
The
regulation of
gene expression, for example, is extremely difficult to
study through the genome alone.
«This
study sheds light on this paradox and uncovers a way by which the stress hormone could prevent diseases, at least psychologically, through
regulation of the Ppm1f
gene» he adds.
The modern
study of
gene regulation started in the 1950s, but researchers only started to unravel the complex array of histone modifications that fine - tune chromatin control of
gene expression 20 years ago.
Thorough
study of changes in the
gene activity
regulation mechanism showed that reprogrammed and embryonic stem cells are similar.
«We set out to find out about human
genes that are implicated in the
regulation of the gut microbiome, and we found some that are,» says senior author Ruth Ley, an Associate Professor in the Department of Microbiology at Cornell University and the
study's senior author.
The researchers said the work demonstrates that, in fact, multi-tissue, multi-individual data can be used to identify the mechanisms of
gene regulation and help to
study the genetic basis of complex diseases.
A new
study involving roundworms appears to have isolated one
gene — a transcriptional factor (or
gene that controls the
regulation of other
genes in the genome)-- that appears to be an essential member of the pathway that translates reduced caloric intake into a longer life span.
Embryonic development is a well -
studied process in which the precise
regulation of
gene expression is critical, since many
genes are expressed simultaneously and in a punctual manner.
While previous research had identified the presence of feed forward loops in plant
gene regulation, «this
study increases the scale enormously,» said Bartley.
While the
study represents a strong start for understanding how eQTLs affect
gene regulation and expression, Engelhardt pointed out that she and her colleagues still do not have enough samples to understand trans - eQTLs as deeply as they would like.
Building on years of mouse and
gene regulation studies, they have developed a resource that can help scientists better understand how similarities and differences between mice and humans are written in their genomes.
«Scientists have learned a lot about development,
gene regulation, and cancer biology, among other things, by
studying C. elegans.
In future
study, we'll focus on the
regulation of HOX
genes in feather cycles.»
Further
studies are needed to determine whether the specific use of transcription starting points is a widely disseminated mechanism for
gene regulation.
In addition to reevaluating how histones control
gene activation, the
study also reports a new mechanism of PARP1
regulation.
A new
study suggests that evolutionary changes in the
regulation of a
gene implicated in perception, behavior, and memory may be partly responsible.
«We realized that
studying the lithium response could be used as a «molecular can - opener» to unravel the molecular pathway of this complex disorder, that turns out not to be caused by a defect in a
gene, but rather by the posttranslational
regulation (phosphorylation) of the product of a
gene — in this case, CRMP2, an intracellular protein that regulates neural networks,» added Snyder.
Asst Prof Li, from the Neural Stem Cells Laboratory at NNI, added, «This important
study suggests a link between a key neurological disease
gene and
regulation of microRNAs in the brain.
He said the genome
study detected changes in one specific
gene involved in the body's temperature
regulation that may be related to metabolic differences in whale cells.
In a
study published online in Genome Research, researchers devised a strategy for genome - wide annotation of primary miRNA transcripts, providing extensive new annotations in human and mouse, and shedding light on mechanisms of
regulation of microRNA
gene expression.
Dubbed model - organism ENCODE (modENCODE), this new focus will apply innovative methods and technologies for the
study of
gene regulation to the smaller, and therefore more manageable, genomes of the fruit fly (Drosophila melanogaster) and the round worm (Caenorhabditis elegans).
The experiments have been carried out using Xenopus laevis oocytes, an animal model used by the laboratory to
study fundamental processes involved in
gene regulation.
In 1984, he moved to the Institute for Molecular and Cellular Biology, at Osaka University (Osaka, Japan), where his research group continued to
study the
regulation of interferon
genes and discovered the interferon - regulatory - factor family of transcription factors.
Our technological expertise ranges from the most fundamental approaches to
study membrane transport in lymphocytes and dendritic cells (subcellular compartmentalization, intravital microscopy, phagosomal functions), the systematic analysis of
gene expression and it
regulation (RNAseq, Chip Seq, proteomics) and physiological and pathological immune responses (mouse models for cancer immunity, immunomodulation / vaccination, human clinical
studies in cancer).
We have also initiated
studies of the
regulation of cytokine
gene expression in these cells.
Fortunately, Deshpande is an expert in
studying leukemic
gene regulation.
The initial work was mainly focused on the
study of the
regulation of muscle chromatin and
gene expression by motor innervation.
Transgenic mice are extremely useful for scientists
studying gene function or
regulation and human diseases, such as Alzheimer's disease.
In
studying the
regulation of
gene dosage, his lab described the first known biological role of a microRNA in the mammalian system, ultimately revealing a network of microRNAs that titrate the dose of key cardiac
gene networks that dictate cell fate and differentiation.
What is known from global
studies is that exposure to biologically active compounds, even at ng / L concentrations, can impact endocrine systems in nature and manifest as negative impacts like altered
gene regulation, the presence of mixed reproductive tissues (intersex) and skewed sex ratios.
Marek is performing postdoctoral research in the lab of Nick Ingolia at UC Berkeley
studying the
regulation of
gene expression.