UC announced yesterday that it is the first research institution to seek to «intervene,» or become a party in the case, in which the government is appealing a lower court's ruling that National Institutes of Health (NIH) funding to
study human embryonic stem cells (hESCs) violates federal law.
Not exact matches
The
study results were found using mouse
embryonic stem cells, which are good
cell models for the
study of processes seen in
human stem cells.
«I think this is the best option we have ever had,» says Renee Reijo Pera, director of Stanford University's Center for
Human Embryonic Stem Cell Research and Education in California, who wasn't involved in the
study.
Some of the researchers at the centre will
study the differentiation of
stem cells into other
cell types, one group by using
human embryonic stem cell biology and another by
studying early embryo development.
For example, animal
studies have shown that neurons derived in the lab from
human embryonic stem cells improve Parkinson's symptoms; however, any residual
stem cells associated with those neurons could form masses of unwanted
cells.
To see whether cancer
stem cell renewal involves a chain of events similar to that used by
embryonic stem cells, and whether the process was affected by oxygen levels, Semenza and graduate student Chuanzhao Zhang focused their
studies on two
human breast cancer
cell lines that responded to low oxygen by ramping up production of the protein ALKBH5, which removes methyl groups from mRNAs.
Partially paralyzed rodents walk almost normally after
human embryonic or fetal brain
stem cells repaired their spinal cord injuries in recent
studies.
Mouse
embryonic stem cells, reported in 1981 by Martin Evans, Matthew Kaufman, and Gail Martin, have allowed scientists to generate genetically customized strains of mice that have revolutionized
studies of organismic development and immunity and have provided countless models of
human disease.
Because fertilized
human embryos are far more accessible than unfertilized eggs, which can not be frozen and stored, extending the result to
humans could lower the practical barriers against creating
human embryonic stem cells to
study and potentially treat disease.
Continued support for biomedical research, and opposition to
human embryonic stem cell studies.
John Gearhart, a
stem cell researcher at Johns Hopkins University in Baltimore, Maryland, says the
study «appears to be the best so far» at offering a potential alternative to
human embryonic stem cells.
In a series of
studies published since 2009, researchers in Wells» laboratory used
human pluripotent
stem cells (hPSCs) to grow
embryonic - stage small intestines with a functioning nervous system, and the antrum and fundus regions of the
human stomach.
Expanding from their previous
studies with mice, the researchers first established that under specific conditions, culturing
human embryonic stem cells with fibroblast growth factor 2 (FGF2) leads to neural differentiation particular to the midbrain / hindbrain region — the location of the cerebellum — within three weeks, and the expression of markers for the cerebellar plate neuroepithelium — the part of the developing nervous system specific for the cerebellum — within five.
Other potential uses of
embryonic stem cells include investigation of early
human development,
study of genetic disease and as in vitro systems for toxicology testing.
What Collins does not say, however, is that the new NIH guidelines also allow for federal funds to be used in
studying new
human embryonic stem cell lines that are created (by private entities, of course) beyond the 700 currently in existence.
Researchers at UCLA treat the first patients in the second FDA - approved
study evaluating a therapy made from
human embryonic stem cells.
That
study found that since MSCRF first began awarding grants in 2007, its pattern of giving shifted over the years from strongly favoring projects focusing on ethically contentious
human embryonic stem cell research (hESCR) to projects focusing on ethically non-contentious adult
stem cells and other non-
embryonic stem cell research.
Enriched population of PNS neurons derived from
human embryonic stem cells as a platform for
studying peripheral neuropathies.
«Discovery of a gene that could convert
human embryonic stem cells into myocardial
cells would be golden,» said Didier Stainier, PhD, UCSF assistant professor of biochemistry and biophysics, the senior author of the UCSF
study and a pioneer in the
study of heart development in the transparent zebrafish embryo.
At present, there are no
embryonic stem -
cell treatments approved by the US Food and Drug Administration, and most
human studies of such therapies have shown unremarkable results.
Recently, his lab used induced pluripotent
stem (iPS)
cells — adult
cells made to act like
embryonic stem cells — made from skin
cells of patients carrying apoE4, or other mutations related to Alzheimer's, to
study their effects on the development, survival, and degeneration of
human neurons.
Dr Ludovic Vallier, co-author on the
study from the Wellcome Trust Sanger Institute and the Wellcome - MRC Cambridge
Stem Cell Institute, said: «This
study represents an important step in understanding
human embryonic development.
Dr. Tajonar obtained her PhD in the laboratory of Prof. Douglas Melton at Harvard University in 2012 where she
studied mechanisms of self - renewal and survival in
human embryonic stem cells.
Dr. Pfaff has developed a novel
embryonic -
stem cell - based model of SMA that phenocopies the pathology of
human SMA, and can be used to
study the basis of the disease and screen for compounds that might increase survival of motor neurons.
A new
study confirms a seemingly obvious assumption about
human embryonic stem cell research: Countries with fewer restrictions on research outperform countries with more restrictions.
The bill, Senate File 162, carves out an exception to Iowa's 2002 ban on
human cloning allowing researchers to use cloning techniques to produce
embryonic stem cells for medical
study.
«Basically, this
study shows that the genetic makeup of individual
human embryonic stem cell lines is unique in the numbers of copies of certain genes that may control traits and things like disease susceptibility,» said Teitell, who also is an associate professor of pathology and laboratory medicine and a researcher at UCLA's Jonsson Comprehensive Cancer Center.
Government regulators have given the go - ahead to a second
study that will for the first time carefully test a treatment created using
human embryonic stem cells in people, according to the company sponsoring the experiment.
Stem Cell Eye Therapy Shows Promise: The study in The Lancet is the first published report on embryonic stem cell use in hum
Stem Cell Eye Therapy Shows Promise: The study in The Lancet is the first published report on embryonic stem cell use in hum
Cell Eye Therapy Shows Promise: The
study in The Lancet is the first published report on
embryonic stem cell use in hum
stem cell use in hum
cell use in
humans.
Microscopic view of a colony of undifferentiated
human embryonic stem cells being
studied in developmental biologist James Thomson's research lab at the University of Wisconsin - Madison.
In the new
study, 12 patients will be treated with healthy scavenger
cells, created in a laboratory from
human embryonic stem cells.
This week, a group of London - based scientists requested official permission from the UK's
Human Fertilisation and Embryology Authority to begin a three - year
study involving
embryonic stem cells.
UC Irvine researchers have discovered a dramatically improved method for genetically manipulating
human embryonic stem cells, making it easier for scientists to
study and potentially treat thousands of disorders ranging from Huntington's disease to muscular dystrophy and diabetes.
Prior to QB3, she
studied mechanisms of self - renewal and survival in
human embryonic stem cells in the laboratory of Professor Douglas Melton, completing her PhD at Harvard University in 2012.
To overcome these hurdles, Bhatia and her team reprogrammed
human skin
cells into induced pluripotent
stem cells (iPSCs)--
embryonic - like
stem cells capable of turning into other specific
cell types relevant for
studying a particular disease.
Recent
studies have demonstrated that some
cells from
human adults have the ability to be reprogrammed to become similar to
embryonic stem cells.