Sentences with phrase «study human macrophages»

They will study human macrophages and dendritic cells isolated from IBD patients with defective GM - CSF function, «The approach represents a step forward in personalizing how we treat patients with IBD,» said Dr. Colombel.

Not exact matches

Now, a study published online April 27th, in the Journal of Immunology, confirms that the cytokine GM - CSF (Granulocyte macrophage colony - stimulating factor) likely plays an important role in human disease and offers a new explanation for why the MS treatment interferon - Beta (INF - β) is often effective at reducing MS attacks.

In earlier studies involving animal models and human cancer cell lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to spread.

The study's researchers infected macrophages, a type of human white blood cell, with a highly virulent strain of tuberculosis.

However, regulatory roles of M2 macrophages in urinary stone formation in humans have not been studied.»

«The protein Smurf1 functions in specialized white blood cells called macrophages in both mice and humans, thereby suggesting a conserved evolutionary pathway,» said Dr. Shiloh, co-senior author of the study along with Dr. Beth Levine, Director of the University's Center for Autophagy Research.

The current study found that mice meant to serve as a model of ischemic human heart failure (weaker blood flow after a heart attack) had higher levels of activated, pro-inflammatory macrophages, monocytes, dendritic cells and T cells trafficking between their hearts and spleens than did control mice with healthy hearts.

Although this study was done in mice, the same mechanisms were found in human macrophages infected with TB.

There are, however, limited in vitro models to study the role of host genetics in the response of macrophages to this obligate human pathogen.

Here, we describe an approach using macrophages derived from human induced pluripotent stem cells (iPSdMs) to study macrophage - Chlamydia interactions in vitro.

The next step is to study the function of macrophages in salamanders and compare them with their human and mouse counterparts.