Last but not least, local authors need to
study more possibilities to distribute their works digitally to reach their audience in a more affordable and effective way.
Not exact matches
These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to
more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the
possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical
studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
It $ ™ s no secret that the bring - your - own - device trend opens up new
possibilities for employees and the businesses they work for, and a
study by communications giant BT finds that
more than 80 percent of IT managers think enterprises can gain a competitive advantage by implementing a BYOD program.
W. E. Sangster, whose
study of Wesley's doctrine of perfection we have noted, is closer to the pietist tradition, and he affirms the
possibility of love
more unequivocally than does Niebuhr.
The
possibility of multi-level
study, discussion, and consultation does nothing
more than take seriously the traditional Reformed conviction that the ministry of the whole people of God is the basic form of the church's ministry.
Therefore, no
study of man can be
more than a description of man's plight and
possibility until it include the prescription by God for man.
If this does turn out to be the case, we will want to examine the
possibility that the
more comprehensive scope of Whitehead's thought may serve an important interpretative and supporting role for Deutsch's investigations of political life, which, in turn, may supply Whiteheadian
studies with a focus for distinctly political problems.
«Although this «rise of the nones» has increased dramatically over recent decades, the rate of increase slowed last year, suggesting the
possibility that there may be a leveling off in this measure in the years ahead,» reports the Gallup
study, which is made up of
more than 350,000 interviews.
As one critic has said of the reliance of Wheelwright's diaphor on epiphor: «The net effect of diaphor is to increase the
possibility of pluri - signification by forcing the reader to create a relationship or a number of relationships,
more or less cognitive, without finally insisting on a particular version» (David M. Miller, The Net of Hephaestus: A
Study of Modern Criticism and Metaphysical Metaphor [The Hague: Mouton and Co., 1971], p. 113).
To be sure, there is here the
possibility of a greater degree of subjectivity than in the
more formal linguistic and textual
study, but even there pure objectivity is by no means possible.
Considering new
studies that point to the
possibility that waiting to introduce allergenic foods may not prove to have any effect on future food allergies [
more on this topic below], the «4 day wait rule» seems unnecessary to some.
As a result, Comstock said, while the authors discuss the
possibility of under - reporting in other
studies, she was «
more concerned with over-reporting in this
study.»
The
study puts a lot of emphasis on the
possibility that employed breastfeeding mothers may reduce their work hours, take longer maternity leaves, switch to
more family - friendly work, or quit work altogether in order to breastfeed.
In a previous
study where we explored women's preferences for aspects of intrapartum care regarding planned place of birth we reported that women with a preference for a hospital birth — both midwife - led and obstetrician - led — found the
possibility of pain relief treatment much
more important compared to women with a preference for a home birth [18].
Some
studies even indicate the
possibility of carrying around cells from our great - grandmothers, though
more research is needed on this to determine how far one can go back to tracing how many fetal cells are in a woman's body.
Considering new
studies that point to the
possibility that waiting to introduce allergenic foods may not prove to have any effect on future food allergies [
more on this topic below], the «4 day wait rule» seems unnecessary to some.
Whether you are
studying basic concepts, such as shapes, colors, relative size, or counting, or
more advanced concepts, such multiplication or fractions, there are plenty of play
possibilities to engage your child.
Though high - volume hydraulic fracturing in Michigan is limited today, the U-M
study takes into account the
possibility that it could become
more widespread due to a desire for job creation, economic growth, energy independence and lower - carbon fuels.
More importantly, the experiment points to the
possibilities of incorporating different forms of locomotion into a single robot, says
study coauthor Robert Wood, a bioengineer at Harvard University.
Dr Webb said: «The results of our latest
study open up the
possibility of designing new drugs that use the same means to attack E. coli, but in a
more effective way.»
Although the
study didn't explain why adults are growing less satisfied, one
possibility put forth by the researchers is that of unrealistic expectations: Modern youth are
more optimistic about their futures than ever before.
Together, the two
studies advance the idea that gut microbes play a role in turning the immune system against nerve cells, causing MS.. It will take a lot
more work to develop cures or preventive strategies based on that, but the research raises the intriguing
possibility of treating an often - devastating disease with something as low - tech as fecal transplants or probiotics.
Other
possibilities include
studies of whether people in positions of power, who already dominate in the public sphere, react
more or less positively to servant brands; and whether products that are advertised as guardians, such as home security systems or particularly safe cars, are perceived differently than servant and partner brands.
More studies will be needed to distinguish between these
possibilities, and to see what else pentaquarks can teach us.
«I think the Cochrane review highlighted the
possibilities and benefits of using clonidine for pre-op sedation, [anxiety] and post-op pain, but we still need
more well - designed, controlled
studies before clonidine can be recommended as the pre-op drug of choice,» Zeltzer said.
The earlier
study — which used pre-industrial temperature proxies to analyze historical climate patterns — ruled out, with
more than 99 % certainty, the
possibility that global warming in the industrial era is just a natural fluctuation in Earth's climate.
In particular, it has been difficult in empirical
studies to rule out the
possibility that evolvability arises and is maintained as a byproduct of selection on organismal features
more directly related to fitness.
The team say the number of
studies was
more limited for these analyses, and the
possibility that other specific fruits and vegetables may also reduce risk can not be excluded.
One such
possibility is suggested by first author of the
study Laura D. Lewis, Ph.D. «This technique now gives us a method for obtaining much
more detailed information about the complex brain activity that takes place during sleep, as well as other dynamic switches in brain states, such as when under anesthesia and during hallucinations.»
Thankfully, Nader and Brunet's
studies suggest much
more benevolent
possibilities.
For the near term, groups known as accelerated development and introduction plans (ADIPs) have
studied the
possibility of
more rapidly introducing new vaccines for rotavirus, a common diarrheal disease, and pneumococcus, a bacterium that causes pneumonia.
Miller and colleagues were intrigued by the
possibility of designing
studies to lower tau in people, but first they needed to see how the oligonucleotide worked in an animal
more similar to people than a mouse.
Budgetmakers in the U.S. Senate want the Department of Energy (DOE) to
study the
possibility of making Earth reflect
more sunlight into space to fight global warming.
«This gives doctors
more possibilities and we can help
more people,» says Professor Lars Jacob Stovner, leader of Norwegian National Headache Centre, who also led the
study.
«If you want to understand the
possibility of life on other planets, it takes
more than just finding one in the same size and orbit as Earth and trying to
study it,» Bennett says.
These
studies raise the
possibility that stress - related neuropsychiatric disorders such as PTSD may be
more effectively treated with 5 - HT - targeted drugs in women and with AVP - targeted drugs in men.
Maria Carrillo, vice president of medical and scientific relations at the Alzheimer's Association, an advocacy group, applauds NIH's giving the trial a green light: Targeting the APOE4 population will «increase the
possibility that participants in the trial will become symptomatic during the period of the
study so that the scientists can assess whether the drug intervention is having an impact on delaying or preventing Alzheimer's symptoms, without having to wait 10 or 15 years or
more,» she says.
The
study showed that children who had been
more distressed as infants and had received less physical contact had a molecular profile in their cells that was underdeveloped for their age — pointing to the
possibility that they were lagging biologically.
Although the notion that sharks and rays are
more resistant to cancers needs rigorous scientific confirmation, the results of this new
study raise the enticing prospect that the proteins produced by these cancer - related legumain and Bag1 genes have modified functions in sharks, including the
possibility of actually protecting the animals from acquiring cancer.
In the latest 161 - page document, dated March 9, EPA officials include several new
studies highlighting how a warming planet is likely to mean
more intense U.S. heat waves and hurricanes, shifting migration patterns for plants and wildlife, and the
possibility of up to a foot of global sea level rise in the next century.
Thomas and colleagues suggest a few ideas for future
study that might help resolve the question, including the surprising
possibility that tidal forces due to Saturn's gravity could be generating much
more heat within Enceladus than previously thought.
After an initial discovery in Germany, this is a field that has been widely
studied in France, including by the Fert team, who recently demonstrated the
possibility of occurrence of these skyrmions at room temperature, making even
more likely their use in practice [2].
[NEWS, 4 June 2013] Protein microarrays, representing
more than one third of all human proteins, provide a unique
possibility to
study complex autoimmune diseases, such as multiple sclerosis (MS).
More studies with even higher energy x-rays are needed to reconstruct the whole text on this and other scrolls, but the technique offers the
possibility of reading works that haven't been seen for nearly 2000 years.
Perhaps even
more alarming to pediatricians is the creeping
possibility, based on
studies of professional boxers, that young boxers could develop chronic traumatic encephalopathy, a condition caused by repetitive blows to the head that can lead to dementia - like symptoms later in life.
And that's why this
study is important; it considered this
possibility but found no evidence that people with mood disorders eat
more sugar — eliminating that option and strengthening the initial hypothesis that a high - sugar diet is bad for mental health.
More research is definitely needed, but these initial
studies show that Vitamin K may be an effective (and inexpensive)
possibility for the future of cancer treatment.
The
study found that SSRIs (selective serotonin reuptake inhibitors) for depression are
more strongly linked to a higher
possibility of a number of unfavorable outcomes in individuals above the age of 65 that suffer from depression in contrast to TCAs (tricyclic antidepressants).
Because the
possibility of bias is greater in case control
studies, prospective
studies are generally given
more weight in the evaluation of the effect of nutrient intake on disease.
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