Sentences with phrase «study novel therapy»
Not exact matches
It also provides novel insight into human mesenchymal stem cell - heart cell interactions that can guide future experimental studies to understand the mechanisms underlying mesenchymal stem cell therapy for the heart.
https://www.sciencedaily.com/
He hopes that further studies may identify novel approaches to immune - based cancer therapy or reveal new drug targets for inflammatory diseases.
«The discovery of the novel progenitor represents a fundamental advance in this field and potentially to the liver regeneration field using cell therapy,» said the study's senior author, Valerie Gouon - Evans, PharmD, PhD, Assistant Professor, in the Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, at the Icahn School of Medicine at Mount Sinai.
The study, «Non-toxic metabolic management of metastatic cancer in VM mice: novel combination of ketogenic diet, ketone supplementation, and hyperbaric oxygen therapy,» was published online today in PLOS ONE.
Our studies have improved our understanding of the basic biology underlying MMA, created a novel animal model for testing interventions and, now, led us to the promise of a new therapy.»
«We are excited that our translational research team of clinicians and basic researchers have come together to present these novel findings and hope that future studies and trials based on this work can move forward to bring targeted therapies for TED,» commented Dr. Phipps.
Trapnell and Suzuki were prompted to test the novel macrophage transplantation therapy by studies showing that resident macrophage populations (such as those residing in the lung) can self - maintain without the cells having to regenerate directly from the bone marrow.
PIND's goal is an integrated, interdisciplinary approach to the study of neurodegenerative diseases and their mechanisms, with the aim of transforming cutting - edge science into novel therapies and diagnostics that directly benefit individuals affected by neurodegenerative diseases.
It demonstrates a completely novel mechanism of predisposition to diabetes that could lead to novel therapies,» says Adrian Vella, M.D., Mayo Clinic endocrinologist and senior author of the study.
The study authors write that using the LSC17 score to single out high - risk patients predicted to have resistant disease «provides clinicians with a rapid and powerful tool to identify AML patients who are less likely to be cured by standard therapy and who could be enrolled in trials evaluating novel upfront or post-remission strategies.»
Four people with paraplegia are able to voluntarily move previously paralyzed muscles as a result of a novel therapy that involves electrical stimulation of the spinal cord, according to a study funded in part by the National Institutes of Health and the Christopher & Dana Reeve Foundation.
The technique «potentially provides ways to create model systems for studying the genetic basis of diabetes, or to discover novel therapies to enhance existing β cells,» Ferrer says.
Now, a new study suggests the drug may also ease the symptoms of a genetic disease called hereditary hemorrhagic telangiectasia — a discovery that could guide researchers to novel therapies for HHT and other vascular diseases.
New studies from the Abramson Cancer Center of the University of Pennsylvania are providing fresh clues on potentially effective combinations with CAR T therapy in brain cancer as well as a novel therapeutic target in head and neck cancer, and also providing greater understanding of the mechanisms of resistance in pancreatic cancer.
Shoemaker has been studying gene therapy as a novel way to treat diseases such as botulism, a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium Clostridium botulinum.
In partnership with the Italian Cystic Fibrosis Research Foundation, we founded a CF animal Core Facility (CFaCore) as a platform for pre-clinical studies and for testing novel antibacterial or anti-inflammatory therapies.
Development of a mouse model of lung chronic infection to study disease progression after NTMs infection and response to novel antibiotic therapies.
«The region - specific cells we found could provide tremendous advantages in the laboratory to study development, evolution and disease, and may offer avenues for generating novel therapies,» says Salk Professor Juan Carlos Izpisua Belmonte, senior author of the paper and holder of Salk's Roger Guillemin Chair.
Failure to respond to this therapy is in fact a major unmet clinical need of solid tumors and this study may help stratify patients and inform novel approaches to improve clinical outcomes.
Our collaborative approach and deep scientific and regulatory understanding of each molecule type helps us shape the best strategy for bringing a novel therapy to market and design custom studies and programs that reduce risk and accelerate timelines.
A Multi-arm, Phase Ib, Open - Label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumour Activity of AZD9291 in Combination with Ascending Doses of Novel Therapeutics in Patients with EGFRm + Advanced NSCLC who have progressed following therapy with an EGFR TKI (TATTON)
«Dr. Meyers» research is a perfect example as to how fundamental laboratory studies are leading to innovative and novel therapies for breast cancer treatment,» says Dr. Raymond Hohl, director of the Penn State Hershey Cancer Institute.
Novel studies are already underway with the goal of preventing and managing relapse in the context of CAR T - cell therapy.
In collaboration with Industry partners, his group has developed a novel non-human primate model to study viral dynamics and the nature of the SIV reservoir under potent anti-retroviral therapy.
To build upon the encouraging early discoveries, Helmsley renewed and expanded its Crohn's funding for the Institute in 2013 to begin new work with three major aims: 1) continue studies of individual genes to determine how genetic differences between Crohn's patients and healthy individuals contribute to the disease; 2) evaluate promising small molecules in disease - relevant studies and prioritize insights from genetics to help develop novel therapeutics; and 3) begin basic experimentation in animal models with Crohn's disease to provide the data necessary to begin testing new therapies in humans.
Phase 1 clinical trials give patients at University of Michigan access to pivotal early - stage studies, connecting families to novel treatment therapies to patients before they are widely available.
In addition, we are studying genetic background effects on onset and progression of ALS symptoms in the mouse model in hopes that these will provide novel targets for therapy.
In addition to discovering a key step in regulating inflammatory processes, these studies may translate into novel forms of therapy.
The new iPS cells generated using novel methods may represent biomedically - and clinically - ideal cells, providing potential platforms for studying human disease mechanisms and achieving the long - term goal of personalized cell - replacement therapy.
Additionally, this technology could provide a novel research model by which we transplant cells in vivo to study a disease and its progression from the onset, as well as directly test how effective new therapies are.»
«She will be instrumental in enhancing our ability to develop novel therapies for pediatric diseases by building a framework that translates clinical studies and research findings into daily practices.»
The present studies provide multiple novel findings relevant to the development of astrocyte transplantation therapies for treatment of the injured or diseased central nervous system.
My studies of cancer genomes have led to characterization of multiple pediatric and adult tumor types, to development of methods that identify and characterize changes in genomic heterogeneity, to defining acquired resistance mechanisms to targeted therapies and to designing novel, personalized vaccines for individual patients.
These studies support the idea that nutrient transporters can be exploited as potential drug targets for cancer therapy and usher us into a new era of novel cancer therapeutics beyond kinase inhibitors and growth factor receptor blockers.
12 Scientific Sessions Radiochemistry: Imaging of Cancer Other Tumors Basic Science Summary Session One Myeloma and Other Marrow Disorders Radiopharmacy: Quality Control and Validation Radiotherapy and Monitoring Therapy Basic Science Summary Session Two Pre-Clinical Systems Breast Cancer Prostate I: Initial Staging Quantification and Methodology of Oncology Studies Novel Radiochemistry: Radiometals
5/7/2007 Targeting Sugar on Blood Vessels May Inhibit Cancer Growth In a study that could point to novel therapies to prevent cancer spread, or metastasis, researchers at the University of California, San Diego (UCSD) School of Medicine have targeted a sugar that supports blood vessel growth in the tumor.
In summary, the present study has shown that miR - 181a is a novel regulator of BMP - Smad signalling and neurite growth, and proposes that targeted inhibition of miR - 181a, given that it is up - regulated in the SN in PD, may be a novel strategy to promote growth of mDA and cortical neurons in regenerative therapies for this disorder.
Phase 1b study of a novel immunotherapy combination therapy of intralesional Coxsackievirus A21 and systemic ipilimumab in patients with advanced melanoma.
Novel immune therapies for prostate and pancreatic cancers, among others, are also in clinical study.
The other novel therapies that are being studied are also at the very early stages.
Researchers at Colorado State University's (CSU) James L. Voss Veterinary Teaching Hospital are seeking feline study participants for a novel stem - cell therapy that could repair the damaged organs of cats with chronic kidney disease.
Dog Studies CANCER Novel Therapies Common heart medications as an effective adjunct therapy for dogs with hemangiosarcoma, an aggressive and deadly cancer.
Veterinary clinical studies conducted to investigate novel therapies or to collect samples or information to gain further understanding of a disease provide the best scientific evidence to guide the clinical care of animals, and oftentimes, people too.
Funded Study: Treatment of Feline Oral Squamous Cell Carcinoma — Evaluation of the Novel Anti-Cancer Drug, IB - DNQ, in Conjunction with Radiation Therapy in Cats Diagnosed with Feline Oral Squamous Cell Carcinoma (FOSCC)
Animal Cancer Foundation is a 501 (c)(3) organization dedicated to finding novel treatment therapies and eventual cures for cancer by funding research in and increasing public awareness of comparative oncology, the study of naturally occurring cancers in pets and people to benefit both.
Dr. Clifford was responsible for the creation of a clinical studies program at Red Bank Veterinary Hospital and brings this expertise to Hope VS. This opportunity will enable Hope VS to offer cutting technologies and novel therapies to our clients not only in oncology but multiple other specialties.
Studies include the investigation of chemotherapeutic agents, novel chemotherapy dosing regimens, and imaging of tumor patients as it relates to radiation therapy.
Tania Libre approaches this subject in a fascinating and novel way, following a therapy session in which Bruguera and Dr. Frank Ochberg, a pioneer in the study of post-traumatic stress, explore the psychological and physical effects of her interrogations and her family past.
This study presents case - series data on a novel outpatient program that blends dialectical behavior therapy (DBT) with standard eating disorder (ED) interventions (i.e., food exposure, weight monitoring, cognitive modification, ED psychoeducation) for patients with complex and multidiagnostic ED presentations.
In their study, West et al6 conducted a randomised controlled trial of a novel intervention called child and family - focused cognitive - behavioural therapy (CFF - CBT), a protocol summarised with the acronym «Rainbow» (box 1) for children (ages 7 — 13) with bipolar disorder.