Sentences with phrase «study of adjuvant»
The only randomized study of adjuvant chemotherapy in mucosal melanoma demonstrated significantly increased relapse - free and overall survival in patients receiving temozolomide and cisplatin, as compared with interferon alfa - 2b or observation.
http://www.cancernetwork.com/ Not exact matches
In addition to a comprehensive study of their use in vaccines, this article summarizes the benefits and challenges associated with the use of these polymer systems as adjuvants.
In a phase 2 trial that included nearly 1,000 adults, the AS03 and MF59 adjuvants (a component that improves immune response of inactivated influenza vaccines) increased the immune responses to two doses of an inactivated H7N9 influenza vaccine, with AS03 - adjuvanted formulations inducing the highest amount of antibody response, according to a study in the July 21 issue of JAMA.
These studies will investigate whether Src kinase inhibitors are best used in the adjuvant setting post-surgery or after chemotherapy to prevent the formation of local and distant disease recurrence.
In my experience, this marks both the first clinical trial of an approved drug with an effect on survival in advanced melanoma in the adjuvant setting, and, in this same setting, the first to study an immune checkpoint inhibitor in the adjuvant setting.
These results open the door for other studies based on checkpoint blockade to try and improve cure rates in the adjuvant setting of melanoma as well as other disease types.
As reported in 2015, the study met its primary endpoint after a median follow up of 2.3 years, with ipilimumab significantly improving recurrence - free survival.2 The drug was subsequently approved by the US Food and Drug Administration as adjuvant therapy for stage III melanoma.
Our intention with this study was to assess Ipilimumab as an adjuvant treatment for patients with completely resected stage III melanoma at high risk of recurrence.
The HOPE study looked at the effect of exercise on body weight, body fat, and inflammatory biomarkers in 121 women with joint pain from taking aromatase inhibitors (AI) as adjuvant therapy.
«By understanding how stress accelerates invasion in aggressive breast tumor cells, this work will inform future studies into whether beta - blockers could be a useful adjuvant therapy in the treatment of some aggressive breast cancers.»
A recent study in the journal Human Vaccines & Immunotherapeutics, showed that two doses of the HPV - 16 / 18 AS04 - adjuvanted vaccine Cervarix (GlaxoSmithKline) are non-inferior to three - doses in the current schedule.
«Our results support the further study and possible development of IL - 33 as adjuvants in vaccinations against pathogens, including in the context of antitumor immunotherapy,» says Weiner.
The US is now funding a large study of countries that used adjuvanted vaccines in 2009 to see if they may have caused narcolepsy.
His laboratory at the German Cancer Research Center in Heidelberg and at the Medical Faculty Mannheim of Heidelberg University is studying the mechanisms of metastasis with the goal to develop more gentle supportive adjuvant therapies for tumor patients without detectable metastases following surgery of the primary tumor.
Final results of a randomised phase III study on adjuvant chemotherapy with 5 FU and levamisol in colon and rectum cancer stage II and III by the Norwegian Gastrointestinal Cancer Group.
«This study demonstrates that Prosigna can reliably identify early stage breast cancer patients who have a low risk - of disease recurrence at 10 years, including a substantial proportion of patients with node - positive disease for whom the risk / benefit derived for adjuvant chemotherapy would be at best neutral,» said Dr. Alessandra Cesano, chief medical officer of NanoString Technologies.
This service will allow users to improve the compatibility and stability of their vaccine antigen with different mucosal adjuvants (from the HZI portfolio) and to define the optimal production methods to generate immunogenic vaccine candidates with optimised physicochemical stability (in vitro studies).
PALLAS: Palbociclib Collaborative Adjuvant Study: A Randomized Phase III Trial of Palbociclib with Standard Adjuvant Endocrine Therapy versus Standard Adjuvant Endocrine Therapy Alone for Hormone Receptor Positive (HR +) / Human Epidermal Growth Factor Receptor 2 (HER2)- Negative Early Breast Cancer
A Phase III, Multicenter, Randomized, Placebo - Controlled, Double - Blind Study Of Atezolizumab (Anti − PD - L1 Antibody) As Adjuvant Therapy In Patients With Renal Cell Carcinoma At High Risk Of Developing Metastasis Following Nephrectomy
Formulation studies, including optimisation of adjuvanted vaccine candidates, stability studies, and the development of analytical methods to characterise antigen - adjuvant combinations
SEATTLE, Feb. 05, 2018 (GLOBE NEWSWIRE)-- NanoString Technologies, Inc. (NASDAQ: NSTG), a provider of life science tools for translational research and molecular diagnostic products, today announced the publication of a landmark study in which Danish researchers used the Prosigna ® Breast Cancer Assay risk of recurrence (ROR) score to accurately predict rates of 10 - year distant recurrence (DR) of cancer in a comprehensive and population - based cohort including all postmenopausal women in Denmark with early - stage hormone receptor (HR)- positive, Her - 2 negative breast cancer who received 5 years of adjuvant endocrine therapy according to nationwide guidelines between 2000 and 2003.
Phase III Study of ADXS11 - 001 Administered Following Chemoradiation As Adjuvant Treatment For High Risk Locally Advanced Cervical Cancer
The rational use of adjuvants will be studied in detail, as very often researchers use a «shotgun» approach with adjuvants, testing entire panels with their antigens in the search for improved immune responses.
The adjuvant setting has been one of the recent areas of interest, but study results have been lackluster.
Enrollment start dates are planned for early to mid-2015 for Part A and mid to late 2016 for Part B. Study products will include NYVAC, another pox - vector vaccine, a DNA vaccine, and protein mixed with one of two different adjuvants.
A Phase I study in AD patients demonstrated good safety and tolerability of multiple injections of aggregated Abeta42 (AN1792) with QS - 21 as adjuvant.
This study is designed to evaluate the safety and efficacy of neoadjuvant and adjuvant atezolizumab in participants with Stage IB, II or IIIA NSCLC who are eligible for surgical resection with curative intent.
Another proposed study will compare different doses of protein and a different adjuvant developed to try to induce higher and more durable antibody responses.
Important reports from the Weiner lab include the first DNA vaccine studied for HIV as well as for cancer immune therapy of cutaneous T cell lymphoma, the early development of DNA encoded genetic adjuvants, including IL - 12, advances in gene optimization, and advances in electroporation technologies resulting in improved gene delivery.
The results obtained by this service may be part of the documentation provided to other analytical services (TNA3), Adjuvants and delivery systems (TNA2) or Immunogenicity and efficacy studies (TNA8) as well as the Pre-clinical GLP production services (TNA4) and the GMP production services (TNA5).
Her laboratory is also studying the function of the vaccine adjuvant alum, which dramatically biases immune responses to TH2 - type cells.
Within the framework of TRANSVAC2, the HZI will offer access in the form of pre-clinical studies in the murine system to assess the immunogenicity, safety and efficacy of specific vaccine formulations containing a mucosal adjuvant.
But the authors of the new study do link stress - reduction techniques with improved immunity: «Added immune control of disease processes, particularly early — when patients were recovering from surgery and receiving adjuvant cancer therapies — may have occurred with the declining stress.»
A 2015 article in the International Journal of Biochemistry and Cell Biology sums up the findings of multiple studies on ketogenic diets and cancer with the following: «there is increasing evidence that the ketogenic diet may also be beneficial as an adjuvant cancer therapy by potentiating the antitumor effect of chemotherapy and radiation treatment.»
We don't have a lot of studies to guide us how many doses of adjuvant can you give at one time in one day safely and what are the health consequences of all those adjuvants.
Mandates for children are particularly disturbing as studies show children are at far greater risk from aluminum adjuvants because of the combination of rapid growth, an incomplete blood - brain barrier and limited ability to eliminate toxins.
The scientists concluded that «this study shows that fenugreek seeds can be used as an adjuvant in the control of type 2 diabetes mellitus in the form of soaked in hot water».
The hypothesis linking adjuvant - induced chronic inflammation to sarcoma formation has been suggested by several authors beginning in the early 1990s.3 - 5 Controversy over the role of adjuvant in sarcoma pathogenesis intensified with the publication of a limited number of studies suggesting there was no significant difference in FISS risk posed by adjuvanted versus nonadjuvanted vaccines.10, 11,19 No studies have been published that suggest an adjuvanted vaccine is safer than a nonadjuvanted vaccine, with respect to FISS risk.
Adjuvants Role in Pathogenesis of FISS In 1993, an epidemiologic study involving 345 cats with fibrosarcoma provided evidence that vaccination with feline leukemia virus (FeLV) and rabies virus vaccines could lead to tumorigenesis at the injection site, particularly when vaccination was repeatedly administered at the same site.6