Sentences with phrase «study of gene activity»

A study of gene activity in the brains of people who suffered from depression reveals that their daily clocks were probably out of whack.

Studies of gene activity have now revealed that many lichens are instead a threesome, with two fungi in the mix.

Based on studies of gene activity and immune cells, he found that these mammals have «domesticated» implantation's inflammatory response.

Studies of gene activity have now revealed that many lichens are not a twosome but instead a threesome, with two fungi in the mix.

Not exact matches

The disruption of prenatal cellular activity in zebra fish, which share 80 percent of their genes with humans and are considered a good model for studying human brain development, seemed to result in hyperactivity, according to the Canadian study, which was published Monday in the Proceedings of the National Academy of Sciences.

Studies involving mice also helped to answer a key question: What turns on the activity of the per and tim genes in the first place?

To get a better view of how this might occur, the researchers looked at gene activity in the anterior pituitary glands of foxes in a breeding program at the Institute of Cytology and Genetics in Novosibirsk, Russia, designed to study the evolutionary processes associated with domestication.

Because the prion - forming protein identified in the study normally functions as a regulator of gene activity, the researchers say their discovery raises the possibility that when it switches to a prion state, it could alter genetic expression and bacterial behavior.

«Our stem cell - based studies indicate that low - calorie sweeteners promote additional fat accumulation within cells compared with cells not exposed to these substances, in a dose - dependent fashion — meaning that as the dose of sucralose is increased more cells showed increased fat droplet accumulation,» said Sabyasachi Sen, M.D., Associate Professor of Medicine at George Washington University in Washington, D.C. «This most likely occurs by increasing glucose entry into cells through increased activity of genes called glucose transporters.»

A new study suggests that epigenetic effects — chemical modifications of the human genome that alter gene activity without changing the DNA sequence — may sometimes influence sexual orientation.

Co-senior author Professor Jennifer Nichols at the Wellcome Trust - Medical Research Council Stem Cell Institute, said: «Our data allow us to study gene activity in individual cells to an unprecedented level of precision.

Judith Zelikoff of NYU Langone Medical Center studied pre - and post-natal exposure to mice of commercially available e-cigarette vapors and aerosols with and without nicotine, finding changes to frontal cortex gene expression associated with mental health and activity issues, some of which are associated with schizophrenia, she said.

In the study published in the journal Science Signaling, the team led by LLuís Espinosa, investigator of IMIM's research group into stem cells and cancer, have shown that inhibition of endosomal activity is a potential therapeutic strategy for the treatment of cancers with the BRAF mutated gene.

Igoshin said that when the researchers set out to find how sporulation decisions were timed to the cell cycle, several studies including prior work by team members, provided a significant clue: Under starvation conditions, the activity of the master regulator gene had been shown to spike once per cell cycle.

According to study co-author Larry J. Young of Emory University, the results provide evidence in a comparatively simple animal model that changes in the activity of a single gene profoundly can change a fundamental social behavior of animals within a species.

Interestingly, this study shows that altered dopamine levels can modify gene activity through epigenetic mechanisms despite the absence of genetic mutations of the DNA.»

They also collected DNA to study epigenetics — changes in the activity of how a gene is expressed through environmental experiences, rather than alteration of the genetic code itself.

This work is part of the ongoing Duke Neurogenetics Study (DNS), a comprehensive study linking genes, brain activity and other biological markers to risk for mental illness in young adStudy (DNS), a comprehensive study linking genes, brain activity and other biological markers to risk for mental illness in young adstudy linking genes, brain activity and other biological markers to risk for mental illness in young adults.

We even did gene - expression studies in flies showing that genes in their brains change their level of activity in waking and in sleep.

Indeed, exposure of the protein produced by the nanoparticle - based gene therapy to the gut mucosa prevents inhibitor development and restores clotting - factor activity in mouse models of both haemophilia A and B. «This approach really could hold big benefit for patients,» says Jörg Schüttrumpf, a transfusion - medicine specialist who led one of the studies performed at the German Red Cross Blood Donor Service in Frankfurt.

The pair of studies bring renewed focus to the epigenetics of T cells — the multilayered system of molecular switches, accelerators, and throttles that controls the activity of genes.

However, all regions of the human brain have molecular signatures very similar to those of our primate relatives, yet some regions contain distinctly human patterns of gene activity that mark the brain's evolution and may contribute to our cognitive abilities, a new Yale - led study has found.

«Our team studied thousands of molecular clues in each of these samples, sifting through extensive data on the activity of genes, proteins and other molecules to identify those of most interest,» says Katrina Waters, a biologist at PNNL and a corresponding author of the study.

«Our team studied thousands of molecular clues in each of these samples, sifting through extensive data on the activity of genes, proteins, and other molecules to identify those of most interest,» said Katrina Waters, the leader of the PNNL team and a corresponding author of the paper.

The researchers studied the activity of a pair of genes called c - fos and c - jun.

The team also recently obtained a grant from the National Medical Research Council in Singapore to pursue a study using the probe to examine the relationship between key Parkinson's disease - linked genes and MAO - B expression and activity to further understand the causes of the disease and illuminate the role of MAO - B in this.

«In this study we weren't looking at how repressing the gene activity affected the symptoms of the disease and this is obviously a critical question as well.

«For the first time, we can provide a complete description of an animal model from genes to behavior — including at the level of neuronal network activity, which has been ignored in most studies to date.»

A study of twins in Brazil suggests gene activity may decide which

Warning: Smoking permanently damages genes Heavy smoking may trigger long - lasting changes in gene activity, possibly explaining the persistently higher risk of lung cancer and disease in those who kick the habit, according to a new study.

In the illustration, each tissue type is followed by the number of genes whose level of activity is controlled by nearby genes on the same chromosome (cis); those whose activity is associated with genes on other chromosomes (trans); and the number of tissue samples studied.

Thorough study of changes in the gene activity regulation mechanism showed that reprogrammed and embryonic stem cells are similar.

Using bioinformatics tools to identify and map out specific components and regulatory interconnections, the study team found highly dynamic activities during CD8 + T cell responses: a distinct repertoire of super enhancers — groups of enhancers that interact with promoters to drive gene transcription, new groups of enhancers that jump into activity only in the memory cell stage, and extensive re-wiring of regulatory circuits from one cell stage to another.

Stice's group also genotyped these young women to determine whether or not they possessed variant alleles of two genes (DRD2 Taq1A A1 and DRD4 - 7 +) that have been linked with lower dopamine activity and, in some studies, obesity.

He has been studying differences in gene expression in infected and uninfected plants and finds that the fungus seems to increase the activity of genes involved in seed production.

In June, he and his colleague Thaddeus Stappenbeck argued in Nature that all mouse studies should use littermate controls: When studying the activity of a particular gene, breed mice with and without that gene by starting with heterozygous parents.

A third study, from the 1,000 Genomes Projects Consortium, showed that in the average person, up to 400 of these ultrarare mutations are likely to disrupt gene activity.

«When we compared the gene signature activity of glioblastoma cells from around 60 patients we found that a large number of patients could be divided into subgroups that showed a correlation between gene activity, tumor cell characteristics and cell of origin similar to the one we had seen in the mouse study.

The senior researchers of the study, Martin Eilers and Juha Klefström are excited about the concept that Myc's ability to turn off rather than turn on genes is a key to cell death: «It is much easier to bring cellular activities down than up with the existing drugs.

Interestingly, many of the genes identified in this study have been shown to have lower gene activity at the molecular level in autistic post mortem brain tissue samples.

Then they generated larvae with a suppressed glycosidase activity by silencing the respective larval glycosidase gene to study the effect of lyciumoside IV ingestion on the disabled larvae.

A new study has found strong evidence that tobacco use can chemically modify and affect the activity of genes known to increase the risk of developing cancer.

Because the RNAi wasn't used to dampen FOXP2 activity until 23 days after the birds hatched, the new study shows that the gene has a role beyond embryonic development, says neurogeneticist Simon Fisher of the University of Oxford in the U.K. «The gene, at least in songbirds, may have important active functions in [neural] circuits,» he says.

In the current study, prediction analysis of gene expression data was implemented in order to identify the genes that are most useful to determine the state of cyclic changes in locomotor activity.

In their comprehensive study, which involved a search of gene activity maps as well as testing of human brain tissue, the researchers identified more than 100 enhancers which were much more active in the brain than in other tissues.

In the current study, the researchers used infradian cyclic locomotor activity in the mutant mice as a proxy for mood - associated changes, and examined their molecular basis in the brain by conducting prediction analyses of the gene expression data.

Reuters reports that «the activity of disease - preventing genes increased while a number of disease - promoting genes, including those involved in prostate cancer and breast cancer, shut down, according to the study published in the journal Proceedings of the National Academy of Sciences.»

Companion studies also shed light on the question of why boys are more likely to develop autism than girls, and begin to outline a network of genes whose activity is altered in the brains of individuals with autism.

The study *, published in the British Journal of Cancer ** today (Wednesday), showed a potential link between the activity of a gene called BCAR4 and the likelihood that a breast cancer tumour will not respond to tamoxifen — widely used to treat women with breast cancer.

Either p53 itself is mutated or there is a problem with one of the proteins that regulate p53's activity,» says the study's leader Geoffrey M. Wahl, Ph.D., a professor in the Gene Expression Laboratory.