Sentences with phrase «study of gene sequences»

At this point, researchers said, only a careful study of gene sequences and morphology can determine whether the source of the brown panda variation is in the air, the soil, or the shrinking genetic diversity of the giant pandas.

Not exact matches

June 19, 2013 — A Cornell University study offers further proof that the divergence of humans from chimpanzees some 4 million to 6 million years ago was profoundly influenced by mutations to DNA sequences that play roles in turning genes on and off.

In the study, whole - exome sequencing and a targeted analysis of 90 genes implicated in heart disease were applied to 419 unrelated SIDS cases.

In the new study, the researchers sequenced the entire genome of mice that had undergone CRISPR gene editing in the team's previous study and looked for all mutations, including those that only altered a single nucleotide.

«Gene sequencing study reveals unusual mutations in endometriosis: Findings advance search for new ways to classify aggressive forms of the disease.»

«Gene sequencing has opened a huge door to how complex these communities are,» says Patrick Seed, a Duke pediatrician specializing in infectious disease, who with biologist Rob Jackson is a lead investigator of the premature infant study.

Gene sequencing is also allowing Jackson and Seed to track down the sources of microbes, both benign and malignant, that find their way into the newborns in the study.

A new study suggests that epigenetic effects — chemical modifications of the human genome that alter gene activity without changing the DNA sequence — may sometimes influence sexual orientation.

The article constitutes the largest sequencing study to date on the genes of representatives from eight sponge genera covering all four currently recognized sponge classes.

Using a novel combination of technologies, including trio exome sequencing of patient / parental DNA and genetic studies in the tiny larvae of zebrafish, the EuroEPINOMICS RES consortium found that mutations in the gene CHD2 are responsible for a subset of epilepsy patients with symptoms similar to Dravet syndrome — a severe form of childhood epilepsy that is in many patients resistant to currently available anti-epileptic drugs.

In a new study, researchers are taking joint biopsy tissue from patients at the start of a new therapy and then six weeks later to see if they can find a predictor gene sequence that will clearly identify which patients respond to a particular therapy.

A new study published in The Journal of Molecular Diagnostics has established that hybrid - capture sequencing is the method of choice for sequencing «actionable» gene mutations across the most common forms of lymphoid cancer.

In this study that used deep DNA sequencing of bacterial specific genes, the guts of both males and females exposed to lead had all of the similar complexity in microbiota as those not exposed.

Traditional molecular systematic studies have progressed by sequencing genes one by one, a time - and cost - intensive task that has limited the amount of data a researcher could feasibly obtain.

With the state - of - the - art DNA sequencing technology used in this study, they will be able to pinpoint the exact mistake in each patient's SS - related genes.

To confirm and strengthen the findings, Zwick and his team are currently performing an independent study of individuals with Down syndrome, using whole genome sequencing to further delineate alterations in genes that perturb heart development in children.

Large - scale methods of probing samples, such as DNA sequencing, microarrays, and automated gene - function studies, are filling new databases to the brim.

Nucleic acid and protein sequences, as well as three - dimensional structures of proteins, are frequently the objects of study, but gene expression as well as the simulation of pathways and biochemical networks are attracting more and more attention.

«If we want to engineer the right microbiome to support plant growth, we need to understand the real function of the microbiome and not just sequence marker genes,» said study co-first author Asaf Levy, a research scientist at the JGI.

But it's very difficult if we don't have information about the optimum sequences for controlling genes,» says Dr Jae - Seong Yang, co-author of the study.

To narrow down this time window, Whitfield studied sequences of three genes from 28 species of wasps — some virus - carriers and some not — and used differences among the species to build a family tree.

The new research focused on just nine genes, those most strongly associated with autism in recent sequencing studies, and investigated their effects using precise maps of gene expression during human brain development.

Because the mouse is so well studied, its sequence will speed the understanding of how our own genes work, says mouse geneticist Barbara Knowles, director of research at the Jackson Laboratory in Bar Harbor, Maine.

Using a battery of comparative tests to study the genome sequences of the giraffe and the okapi, the scientists discovered 70 genes that showed multiple signs of adaptations.

Wellems's team was studying chromosome 7 of P. falciparum in search of a gene that renders malaria resistant to the drug chloroquine, when they came across a cluster of five related genetic sequences.

To study gene expression, they then examined RNA sequencing data from 25 of the biliary - phenotype cancers and 44 hepatocellular cancers.

The largest - ever study to sequence the whole genomes of breast cancers has uncovered five new genes associated with the disease and 13 new mutational signatures that influence tumour development.

The first study to sequence and analyze the entire genome of a HeLa cell line, along with access to its sequence data, has been published Aug. 7 in its final version, by G3: Genes Genomes Genetics, an open - access, scientific journal of the Genetics Society of America.

The advent of genomics and rapid sequencing techniques has seen HeLa cells used in numerous large - scale studies of gene function and expression.

So geneticists have been focusing on the dog as a possible model for gene searches because this lack of sequence variation may help them circumvent a frequent problem with studies in humans.

The study, «Transcriptome Sequencing Implicates Dorsal Striatum - Specific Gene Network, Immune Response and Energy Metabolism Pathways in Bipolar Disorder,» [http://www.nature.com/mp/journal/vaop/ncurrent/full/mp201694a.html] was supported by funding from the State of Florida.

The study used whole - exome sequencing to characterize genetic alterations that occur at the single nucleotide level for all genes in 25 cell lines commonly used as models of bladder cancer.

Recent studies have found elevated levels of this protein in post-mortem brain samples of patients with MS.. In this latest work, investigators compared the frequencies of «more active» and «less active» variants of the DNA sequences that control expression of the galanin gene between healthy controls and MS patients.

«Scientists sequence genomes of microscopic worms beneficial to agriculture: Study identifies gene families in five nematodes that are likely to be involved in parasitism.»

Canadian researchers conducted a pilot study with 20 newborns to determine the effectiveness of a targeted next - generation sequencing panel that included all 4813 genes currently known to be associated with rare diseases.

This is the first study in human trials to identify genes driving acute peanut allergic reactions using a double - blind placebo - controlled approach with comprehensive sequencing of genes expressed before, during, and after they ingested peanut.

This study further investigated the impact of nicotine use / smoking status and variation in the mu opioid receptor gene (OPRM1), specifically, an A118G single nucleotide polymorphism (SNP, or DNA sequence variation), on the effects of naltrexone on a range of drinking outcomes.

Dan Graur of Tel Aviv University bases his surprising claim on a study of genetic mutations, which produce changes in the amino acid sequence of the protein a gene codes for, and which are assumed to accumulate at a fairly steady rate.

More recently, improved gene - sequencing technology and larger population studies have made it possible to detect gene variants that appear in only 1 percent of the human population.

The study examined DNA methylation — an «annotation» of DNA that alters gene expression without changing the genomic sequence itself — in a group of diverse Latino children.

Some scientists have criticized TCGA for focusing on gene sequencing while diverting funds from functional studies that can determine which of the hundreds of mutations are most important.

The Yale - led study performed whole exome sequencing ¬ — a technique for sequencing all the expressed genes in a genome ¬ — on TNBC tumors to identify mutations in specific genes or pathways that may indicate response or resistance to the standard of care, which is anthracycline / taxane (ACT) chemotherapy.

The newest study from the Autism Speaks MSSNG project — the world's largest autism genome sequencing program — identified an additional 18 gene variations that appear to increase the risk of autism.

«These sequences then become the targets for a far narrower set of follow - up gene function studies in F. graminearum by reverse genetic experimentation to pinpoint the genes essential for the disease - causing abilities of this pathogen.»

They're continuing to sequence prostate tumors to learn how frequently different mutations occur, as well as studying which of the rearranged genes are actually driving cancer.

The team identified eight new genes involved in this type of epilepsy thanks to their use of whole - genome sequencing, which had never been done before in an epileptic study of this scope.

Brunner is a co-author of an article in an August 2014 issue of Nature Geneticsabout the study, which identified gene sequences from Populus trichocarpa, commonly known as black cottonwood.

«There has to be a functional way of assessing the role of these cancer - gene candidates as they appear in sequencing studies,» Sanchez - Rivera says.

Epigenetics is the study of changes to DNA packaging that influence which genes are expressed but don't affect the DNA sequence itself.

Brunner is co-author of an article in the Aug. 24 issue of Nature Genetics about the study, which identified gene sequences from Populus trichocarpa, commonly known as black cottonwood.