Sentences with phrase «study of the aggregation»

F. Mantegazza also developed combined light scattering, fluorescence and AFM techniques for the study of the aggregation behavior of Abeta peptides and liposomes.

Not exact matches

«Since the loop has been found to be a key segment in prion protein aggregation, this site could be targeted for the development of new therapeutics designed to block prion conversion,» said Christina Sigurdson, DVM, PhD, associate professor at UC San Diego and UC Davis and senior author of the study.

I was studying a handful of families in which people had inherited a recessive disease affecting platelet aggregation, looking for mutations in their genomic DNA.

In a study published online in Genome Research, researchers developed a novel computational strategy to identify interaction partners of the huntingtin protein and discovered a novel factor that suppresses misfolding and aggregation.

These studies have paved the way for the development of new aggregation - prevention drugs.

This confirms our assumption that the suppression of the aggregation of proteins represents a promising therapeutic approach for a large number of neurodegenerative disorders that are currently still incurable,» says Hartl, summarizing the results of the study.

Wolynes considers the new study a beachhead to launch others to determine the entire process of how memories form, as well as the implications for diseases like Alzheimer's and Parkinson's that involve protein aggregation.

«The novel pheromone activates two different circuits: one is involved in courtship and mating of males and females, the other one in aggregation,» Markus Knaden, who led the studies, explains.

That study was the lab's first attempt to model the energy landscape of amyloid aggregation, which has been implicated in Alzheimer's disease.

Detailed findings of this study are reported and discussed in «Evaluation of S100B in the diagnosis of suspected intracranial hemorrhage after minor head injury in patients who are receiving platelet aggregation inhibitors and in patients 65 years and older,» by Heinrich Wolfgang Thaler, MD, Jochen Schmidsfeld, MD, and colleagues, published today online, ahead of print, in the Journal of Neurosurgery.

John Lew, associate professor in the Department of Molecular, Cellular & Developmental Biology, also participated in this study, as well as previous research that has demonstrated cinnamon extract's inhibitory effect on tau aggregation.

«Our findings have challenged the notion of the aggregation process as a passive consequence of accumulating misfolded proteins,» says Stowers Investigator Rong Li, Ph.D., who led the study.

The study, «Gut bacteria mediate aggregation in the German cockroach,» was published in the Proceedings of the National Academy of Sciences.

«Heat - induced aggregation has all the hallmarks of an adaptive response,» said study author Edward Wallace, PhD, postdoctoral scholar in biochemistry and molecular biology at the University of Chicago.

Three species of shark, tiger, lemon and Caribbean reef, all use deeper coral reefs in the Virgin Islands, but only lemon shark presence was associated with seasonal grouper spawning aggregations, according to a study published May 4, 2016 in the open - access journal PLOS ONE by Alexandria Pickard from Nova Southeastern University, Florida, Bradley Wetherbee of the University of Rhode Island and colleagues.

A series of exciting recent studies suggested that the process of protein misfolding and aggregation implicated in various PMDs can be transmitted by administration of preformed, misfolded protein aggregates, in a way reminiscent of the transmission of prion diseases by infectious prions (Prusiner, 2012; Soto, 2012; Jucker and Walker, 2013).

The study also led to several other discoveries: the first multicomponent pheromone, synergism among inactive components in pheromones, the contribution of the host plant to aggregations, and the chemical interplay between several species of bark beetles and their associated predators.

However, the extent to which spreading of IAPP aggregation may contribute to diabetic alterations needs to be further studied in more detail.

Studying the structure of the cone snail insulin could help researchers modify human insulin to lose its self - aggregation but retain its potency, Safavi says.

Another important conclusion of our studies from the point of understanding T2D is the potential role of IAPP misfolding and aggregation in the etiopathogenesis of the disease.

Familial aggregation studies show that first degree relatives of probands with AD are more likely to have or develop AD compared to relatives of controls.

We also study small secretory chaperones, which participate not only in convertase maturation but also in blocking aggregation of neurodegeneration - related proteins in the secretory pathway.

Our studies on convertase - mediated opioid peptide synthesis are relevant to the control of pain pathways, while our work on two secretory chaperones (first identified through their potent blockade of convertase aggregation) is of potential interest to patients with Alzheimer's and many other neurodegenerative diseases involving protein aggregation.

AβPP transgenic mouse lines differ in the types and amounts of Aβ that they generate and in their spatiotemporal patterns of expression of Aβ assemblies, providing a toolkit to study Aβ amyloidosis and the influence of Aβ aggregation on brain function.

Current studies of protein aggregation and disease come with a high price tag in labor and time.

With his Pioneer Award, Ismagilov will develop droplet - based microfluidic technologies for quantitative studies of protein aggregation diseases and aging at the molecular level and in entire organisms.

Conserving spawning aggregations not only conserves the large reproductive individuals that sustain the population, but, according to our study, ensures the success of their larvae,» said lead co-author Megan Donahue, an associate professor of marine biology at the University of Hawaii and member of the «Pretty Darn Good» Control Working Group at NIMBioS who helped produce the study.

DG041 is a novel, first - in - class, orally - administered small molecule which has been shown in preclinical studies to be a selective and potent antagonist of the EP3 receptor for prostaglandin E2 (PGE2), inhibiting human platelet aggregation in a dose - dependent manner.

We analyzed the structural locations of the pathogenic missense variants from this study and the literature, as well as population missense variants extracted from Exome Aggregation Consortium (ExAC).

In the new study, she and her colleagues have now shown that FUS aggregation results from a liquid - liquid phase separation analogous to the gradual coalescence of oil droplets dispersed in an oil - water emulsion.

(Source) Another study discovered that strawberry extract inhibits platelet aggregation, which causes thrombosis, by inhibiting the inflammatory mechanisms of atherosclerosis.

-- Several studies have shown that stress (due to elevated adrenaline levels) increases the risk of platelet aggregation.

Where Campbell's The China Study is the «grand prix» of nutrition and epidemiology, Robbins's work is the «slam dunk» aggregation of all the studies showing that a highly plant - based diet is the foundation of good health.

There are significant unresolved issues in all studies - about the adequacy of controls for family background, the possibility of differential bias at different levels of aggregation, and the use of weak measures of achievement and spending.

Other AgMIP initiatives include global gridded modeling, data and information technology (IT) tool development, simulation of crop pests and diseases, site - based crop - climate sensitivity studies, and aggregation and scaling.

Architensions reimagined the tent typology for Greenpoint Open Studios 2017 hosted by Java Studios, studying a simple assembly of bamboo poles to maintain the idea of an easy and fast aggregation of elements and at -LSB-...]

Aggregation through meta - analysis is described next, followed by joint attribution through climate model studies, and synthesis of the observed changes described in Section 1.3.

We do have an INDC [Intended nationally - determined contributions] system in operation now and many studies indicate that those preliminary [INDC's] and judging from submissions from the Cancun pledges, many studies indicate that the aggregation of the pledges from the individual countries is very over the 2C stabilisation goal.

The top two most recent posts from each of these services were included, so as to reduce the risk of skewing the case study toward a particular aggregation service's style of blog post.

However, studies of this association in children and adolescents are often restricted by the use of global measures of mental health problems and aggregation of SES - indicators.

The familial aggregation of common psychiatric and substance abuse disorders in the National Comorbidity Survey: A family history study