Sentences with phrase «study regulation of gene»

Tapscott applies the method to study regulation of gene expression in normal development of muscle tissue, while Olson uses it to identify genetic profiles of brain - cancer development.

To uncover molecular processes in individual cells and to understand the full complexity of biological systems, our lab applies and develops novel microscopy and genomics based techniques to study the regulation of gene - expression in single cells.

In studying the regulation of gene dosage, his lab described the first known biological role of a microRNA in the mammalian system, ultimately revealing a network of microRNAs that titrate the dose of key cardiac gene networks that dictate cell fate and differentiation.

Marek is performing postdoctoral research in the lab of Nick Ingolia at UC Berkeley studying the regulation of gene expression.

The Kind group studies the regulation of gene expression in single cells by developing and using novel microscopy and genomics based techniques.

Not exact matches

Using blood samples, the study found that regulation of the oxytocin receptor gene OXTR was associated with development of the condition.

But a new study, published today in Nature, has revealed that m6A plays a key role in the regulation of the Sex - lethal (Sxl) gene, which controls sex determination of the fruit fly Drosophila.

Although the regulation of this gene has a strong «cell cycle control» component, I was more interested in studying cell cycle regulation «proper.»

For example, the study found down - regulation of genes involved in interferon tau, the major signal of pregnancy recognition.

After having conducted a large - scale study performed on cells from the umbilical cords of 204 newborns, the researchers from UNIGE demonstrate that DNA methylation may play both a passive and active role in gene regulation.

To find answers to these questions, the scientists studied the gene regulation of the DPP4 gene in mice that are prone to obesity.

The study identified five genes predictive of feeding success representing a range of biological systems: sensory integration (NPHP4, PLXNA1); hypothalamic regulation, a region of the brain that plays a key role in hunger signaling (NPY2R); facial development (WNT3, a gene associated with lip and palate development); and energy expenditure (AMPK, a regulator of whole body energy balance).

Booij and her colleagues hope that this study will shed more light on the specific role of early environmental influences on brain development, gene expression and emotional regulation.

«Single gene variation linked to obesity: Variation in the BDNF gene may affect brain's regulation of appetite, study suggests.»

«What is important in our study is that we proved that there was a unique and consistent solution to the fitting problem, something that has never before been achieved for a realistic complex model of gene regulation,» stated Dr. Jaeger.

The protein studied in the mold is part of a larger family of proteins also found in humans and involved in many essential biological processes including gene regulation and fatty acid metabolism.

In a study recently published in the journal Neuro - Oncology, a team of scientists led by Luni Emdad, M.B.B.S., Ph.D., and Paul B. Fisher, M.Ph., Ph.D., provided the first evidence of an important link between a specific microRNA, miR - 184, and a cancer promoting gene, SND1, in the regulation of malignant glioma.

The regulation of gene expression, for example, is extremely difficult to study through the genome alone.

«This study sheds light on this paradox and uncovers a way by which the stress hormone could prevent diseases, at least psychologically, through regulation of the Ppm1f gene» he adds.

The modern study of gene regulation started in the 1950s, but researchers only started to unravel the complex array of histone modifications that fine - tune chromatin control of gene expression 20 years ago.

Thorough study of changes in the gene activity regulation mechanism showed that reprogrammed and embryonic stem cells are similar.

«We set out to find out about human genes that are implicated in the regulation of the gut microbiome, and we found some that are,» says senior author Ruth Ley, an Associate Professor in the Department of Microbiology at Cornell University and the study's senior author.

The researchers said the work demonstrates that, in fact, multi-tissue, multi-individual data can be used to identify the mechanisms of gene regulation and help to study the genetic basis of complex diseases.

A new study involving roundworms appears to have isolated one gene — a transcriptional factor (or gene that controls the regulation of other genes in the genome)-- that appears to be an essential member of the pathway that translates reduced caloric intake into a longer life span.

Embryonic development is a well - studied process in which the precise regulation of gene expression is critical, since many genes are expressed simultaneously and in a punctual manner.

While previous research had identified the presence of feed forward loops in plant gene regulation, «this study increases the scale enormously,» said Bartley.

Building on years of mouse and gene regulation studies, they have developed a resource that can help scientists better understand how similarities and differences between mice and humans are written in their genomes.

In future study, we'll focus on the regulation of HOX genes in feather cycles.»

Further studies are needed to determine whether the specific use of transcription starting points is a widely disseminated mechanism for gene regulation.

In addition to reevaluating how histones control gene activation, the study also reports a new mechanism of PARP1 regulation.

A new study suggests that evolutionary changes in the regulation of a gene implicated in perception, behavior, and memory may be partly responsible.

«We realized that studying the lithium response could be used as a «molecular can - opener» to unravel the molecular pathway of this complex disorder, that turns out not to be caused by a defect in a gene, but rather by the posttranslational regulation (phosphorylation) of the product of a gene — in this case, CRMP2, an intracellular protein that regulates neural networks,» added Snyder.

Asst Prof Li, from the Neural Stem Cells Laboratory at NNI, added, «This important study suggests a link between a key neurological disease gene and regulation of microRNAs in the brain.

In a study published online in Genome Research, researchers devised a strategy for genome - wide annotation of primary miRNA transcripts, providing extensive new annotations in human and mouse, and shedding light on mechanisms of regulation of microRNA gene expression.

Dubbed model - organism ENCODE (modENCODE), this new focus will apply innovative methods and technologies for the study of gene regulation to the smaller, and therefore more manageable, genomes of the fruit fly (Drosophila melanogaster) and the round worm (Caenorhabditis elegans).

This work is one basis for the use in the scientific community of transgenes as a major technique to study gene regulation in normal and malignant cells.

In 1984, he moved to the Institute for Molecular and Cellular Biology, at Osaka University (Osaka, Japan), where his research group continued to study the regulation of interferon genes and discovered the interferon - regulatory - factor family of transcription factors.

Our technological expertise ranges from the most fundamental approaches to study membrane transport in lymphocytes and dendritic cells (subcellular compartmentalization, intravital microscopy, phagosomal functions), the systematic analysis of gene expression and it regulation (RNAseq, Chip Seq, proteomics) and physiological and pathological immune responses (mouse models for cancer immunity, immunomodulation / vaccination, human clinical studies in cancer).

We have also initiated studies of the regulation of cytokine gene expression in these cells.

The initial work was mainly focused on the study of the regulation of muscle chromatin and gene expression by motor innervation.

What is known from global studies is that exposure to biologically active compounds, even at ng / L concentrations, can impact endocrine systems in nature and manifest as negative impacts like altered gene regulation, the presence of mixed reproductive tissues (intersex) and skewed sex ratios.

Transcriptome studies such as the National Institute of Health's Genotype - Tissue Expression (GTEx) program aim to overcome this limitation by studying gene expression levels and regulation mechanisms and their relationship with diseases, instead of only DNA sequence.

But more importantly this old study (by mitochondrial membrande phospholipid fatty acids composition remodeling towards a low perodizable index PI and double bond unsaturation index DBI by genetically reduced desaturase (essentially switching perodizable polyunsaturates with monounsaturates / saturates, rendering membranes lipid peroxidation resistant / blocking hydroperoxide formation by DHA n - 3 and lowering mitochondrial DNA lesions formation by membrane lipid peroxidation chain propagation), It's true though that these effects are due to transcriptional lipid genes regulation (so the genes are the reason of this dramatic effect and this is also a gene therapy, that hit the key points) this old study showed

These studies are unable to determine a causal relationship due to factors such as gene regulation — a genetic variant may instead contribute to altered expression levels of true causal genes, which remain undetected by a GWAS.

In this study, we also identify p21waf1 / cip1 as a target gene of DDX3, and the up - regulation of p21waf1 / cip1 expression is linked to the growth - suppressive effect exerted by DDX3 (see Fig. 2).

Studies could include examining the activation and deactivation of genes (e.g., transcription factors or epigenetic regulation) or involve more classical genetic identification sStudies could include examining the activation and deactivation of genes (e.g., transcription factors or epigenetic regulation) or involve more classical genetic identification studiesstudies.

She obtained her PhD in molecular biomedicine from University of Tartu studying the genetic regulation of gene expression.

Fortunately, Paul Flicek and his colleagues at EMBL - EBI are rising to the challenge by helping to curate, catalogue and give access to the masses of genetic data being generated globally — not just gene sequences, but outcomes of studies into everything from gene regulation to protein function.

We study learning and memory at the genetic level to understand the structure, regulation, evolution and biological function of genes that are required for normal learning and memory.

«It may have relevant implications for researchers worldwide studying gene regulation in general since we know now that the large - scale organization of the genome can not be ignored.