For the moment, Blue Brain scientists
study rodent brain tissue and characterize different types of neurons to excruciating detail, recording their electrical properties, shapes, sizes, and how they connect.
Not exact matches
Neuroscientists have over the past decade uncovered evidence, both in
rodent and human
studies, that parental caregiving, especially in moments of stress, affects children's development not only on the level of hormones and
brain chemicals, but even more deeply, on the level of gene expression.
In other
studies, Sonntag's group has shown that infusing IGF - 1 into the
brain improves memory and learning in elderly
rodents.
The findings support other recent
rodent studies that showed drugs that enhance the action of BDNF can reduce
brain changes and symptoms of Huntington's disease.
Perhaps most significantly, in a
study led by Frances Champagne — then a graduate student in Meaney's lab, now an associate professor with her own lab at Columbia University in New York — they found that inattentive mothering in
rodents causes methylation of the genes for estrogen receptors in the
brain.
The specifics have yet to be ironed out, but the Amgen team has uncovered a few clues in their
rodent studies: They found treated animals had increased activation of certain neurons in the
brain that detect blood sugar, and this may have helped them sense when it was time to stop eating.
Partially paralyzed
rodents walk almost normally after human embryonic or fetal
brain stem cells repaired their spinal cord injuries in recent
studies.
Research in
rodents, along with imaging
studies in new mothers, are finding areas of the
brain that could be involved in postpartum depression.
In this proteomic
study, Jianyun Yu, Hu Zhou and colleagues assessed
brain protein levels after one or more concussions in
rodents at multiple timepoints.
A compound that blocks iron - containing enzymes in the
brain improves recovery following
brain hemorrhage, a new
study in
rodents shows, and it works in an unexpected way.
The cortex is the thin layer of cells on the surface of the
brain that governs many functions, and in elephants it contains a greater variety of cell types (such as the extensively branched neuron pictured above) than is found in more frequently
studied animals such as
rodents and primates.
In two new
studies, researchers have found a way to stimulate the
brains of
rodents to activate a specific memory trace.
But the authors of a new
study on dying rats make a bold claim: After cardiac arrest, the
rodents»
brains enter a state similar to heightened consciousness in humans.
«Our findings are clinically relevant as they identify a novel addiction target in
rodents, along with parallel supporting evidence from
brain imaging
studies in human addicts,» explains Andon Placzek, lead author of the nicotine
study.
Dr Richard Melloni, who led the research, said that because the part of the
brain which his team
studied is similar in
rodents and humans, the scientists say their findings are probably applicable to people.
He spent his basic research career
studying the mechanisms of steroid hormone action on the
brain, behavior, and mental health, and the influences of the environment and stressors on those actions in laboratory
rodents.
Paul Sawchenko uses cell biological and genetic approaches in
rodent models to
study how stress - responsive systems are organized at a molecular level within the body and particularly within the
brain.
Although these
studies were conducted in
rodents, it's not far - fetched to say that the same primitive processes are occurring in the human
brain, too.
One
study in
rodents showed that elevated amounts of acetate in the blood suppressed appetite by affecting
brain function.
A further
study on the semi-precocious
rodent Octodon degus [132] showed that short, repeated separations in the first three weeks of life resulted in significant alterations of density of neurons releasing corticotropin releasing factor (CRF) in
brain regions involved in emotion regulation.