We study the signal transduction pathways regulating cell growth and proliferation, with an emphasis on kinase enzymes.
Computational biology; use of control and information theory to
study signal transduction pathways.
Not exact matches
at The Scripps Research Institute and the Burnham Institute, and also at the National Institutes of Health, where her
studies spanned
signal transduction, cell migration, and neuronal development.
Bowen's lab
studied several sigma receptor areas, including
signal -
transduction pathways, novel binding elements (both agonists and antagonists), and clinical applications.
Recent
studies such as ours, however, establish protein phosphatases as positive and essential regulators of
signal transduction, with remarkable substrate specificity and coordinated activities.
During the early years of my PhD
studies, I was very fascinated by the exciting discoveries in the field of
signal transduction, in particular how receptor tyrosine kinases are activated to transmit their
signals and how protein complexes are formed through defined protein folds (domains) interacting with specific cellular targets.
In 1995, I began graduate
studies on
signal transduction by growth factors and receptor tyrosine kinases in the laboratory of Graeme Guy at the Institute of Molecular and Cell Biology (IMCB) in Singapore, obtaining my PhD in 2000.
I
studied the process called
signal transduction - transmission of the activating mechanical
signal from outside the cell, across the cellular membrane, to FAK inside the cell, leading to the activation of the kinase.
Intra - and intermolecular
signal transduction mechanisms in membrane - embedded (photo --RRB- receptor / transducer complexes are
studied using the photoreceptor / transducer complex NpSRII / NpHtrII, which is responsible for the photoactive behavior of the halophilic archaeon Natronomonas pharaonis.
«Cell surface receptors for
signal transduction and ligand transport - a design principles
study.»
The
studies described in this article directly compared the functional characteristics of T cells deficient in two intracellular negative regulators of TCR
signal transduction, DGKζ and Cbl - b.
Studies of satellite cell activation via nitric oxide have opened an exciting area of research on muscle regeneration, growth and the muscle - fiber cytoskeleton that integrates mechanical and biochemical
signal transduction with cell and molecular biology of muscle tissue in growth, development, disease, aging and evolution.
The Neurophysics Group has the objective to
study physical mechanisms underlying
signal perception and
transduction in the nervous system and to apply experimental physics methods to problems in neuroscience.
Recent
studies have shown that ALA has a positive impact on insulin action (via the insulin
signal transduction pathway) and muscle glucose transport, especially in people whose insulin function is suboptimal, i.e. have developed insulin resistance.
However, there is evidence from recent
studies that one antimicrobial effect in bacteria is related to monolaurin's interference with
signal transduction (Projan et al 1994), and another antimicrobial effect in viruses is due to lauric acid's interference with virus assembly and viral maturation (Hornung et al 1994).
The
study, Fish oil ameliorates trimethylamine N - oxide - exacerbated glucose intolerance in high - fat diet - fed mice, found that in mice, dietary FO ameliorated TMAO - induced impaired glucose tolerance, insulin
signal transduction in peripheral tissue, and adipose tissue inflammation in HFD - fed mice.