Mice in which telomeres have been lengthened by gene therapy tended to live longer in
some studies than mice that didn't get the treatment.
Rhinos are much less
studied than mice — but Jeanne Loring, director of the Center for Regenerative Medicine at the Scripps Research Institute, has already turned northern white rhino cell cultures into pluripotent stem cells.
Not exact matches
Findings from a 2010
study in the Journal of Nutrition demonstrated that blueberry - fed
mice had less atherosclerotic plaque
than the
mice that did not receive blueberry supplementation.
Not only would the new method, tested only in
mice, be more convenient but also more effective
than the flu shot or nasal spray, according to a
study at the International Vaccine Institute in Seoul.
«How obesity dulls the sense of taste: Obese
mice had about 25 percent fewer taste buds
than lean
mice in
study.»
However, this
study revealed that
mice are more similar to humans
than previously thought, with an average of around 10 % of active genes escaping X-inactivation per tissue.
«Our
study shows that epigenetic drift, which is characterized by gains and losses in DNA methylation in the genome over time, occurs more rapidly in
mice than in monkeys and more rapidly in monkeys
than in humans,» explains Jean - Pierre Issa, MD, Director of the Fels Institute for Cancer Research at LKSOM, and senior investigator on the new
study.
On reanalysing data from the group's past
studies, such as on pain sensitivity to hot water, the researchers found that
mice tested by men showed lower baseline pain sensitivity
than mice tested by women.The work indirectly demonstrates potential effects on nearly any kind of medical research, says Joseph Garner, who
studies mouse behavior and well - being at Stanford University in California.
In a
study, when
mice ate broccoli with their regular diet, they were better able to tolerate digestive issues similar to symptoms of leaky gut and colitis
than mice that were not placed on a broccoli - supplemented diet, according to Gary Perdew, the John T. and Paige S. Smith Professor in Agricultural Sciences, Penn State.
«Our research suggests that in
mice, males may be more vulnerable to the effects of maternal inflammation
than females, and the impact may be life long,» says
study leader Irina Burd, M.D., Ph.D., an assistant professor of gynecology / obstetrics and neurology at the Johns Hopkins University School of Medicine and director of the Integrated Research Center for Fetal Medicine.
They
studied the bone metabolism at the cellular level using advanced imaging and computational techniques, which allowed them to identify 142 metabolites that were significantly altered by more
than 1.5 times in the diabetic
mice.
In the
study, led by post-doctoral fellow Long N. Nguyen of Duke - NUS, researchers found that
mice without the Mfsd2a transporter had brains a third smaller
than those with the transporter, and exhibited memory and learning deficits and high levels of anxiety.
This scheme mimics a human scenario better
than the recent
study, which analyzed
mice that express or lack APOE from birth.
Dr Luis Pedro Coelho, commented: «These findings suggest that dogs could be a better model for nutrition
studies than pigs or
mice and we could potentially use data from dogs to
study the impact of diet on gut microbiota in humans, and humans could be a good model to
study the nutrition of dogs.
Three groups of middle - aged
mice (about a year old) were
studied: one group ate a normal diet, in which fewer
than 30 percent of calories came from fat, while two others were fed high - calorie diets in which 60 percent of the calories came from fat.
The less - complex nervous system of the fruit fly makes them easier to
study than people or even
mice, another genetic model organism.
The
study «provided the surprising result that one new therapy currently being explored to lower insulin resistance promotes, rather
than decreases, the formation of bone in
mice,» says Darwin Prockop, a stem cell researcher at Texas A&M College of Medicine in Temple, who was not involved in the work.
In fact, both of the
studies found that when adenosine was turned on in
mouse tissue by other mechanisms, the pain response was equal to or better
than the response generated by acupuncture.
Neurobiologist Gordon Fishell lost about 2,500
mice representing 40 genetic variants, which he had developed for
studies of forebrain development over more
than a decade.
But a
study of
mice shows that breast cancer cells decamp in groups, and the clumps of cells have a better chance of establishing a colony
than loners do, Kevin Cheung of Johns Hopkins University reported December 7 at the annual meeting of the American Society for Cell Biology.
They were also more sensitive to alcohol's effects
than the normal
mice were;
studies have shown that the more sensitive a person is to alcohol, the less likely he or she is to abuse it.
A
mouse study suggests marijuana may have the opposite effect on older people
than it has on the young, boosting learning and memory instead of impairing it
In the new
study, Ji's group put SHANK3 - deficient
mice through a battery of sensory tests, finding that the animals had lower sensitivity
than normal
mice to heat and heat - related pain — akin to the soreness a person feels after a sunburn.
«The researchers also overdosed the
mice tested in their
study with levels of the ingredient at a rate hundreds of times greater
than what would be consider a safe use level (based on EPA standards),» DeLeo said in an email.
The team's recent
study in
mice has found that the treatment reduced the mass of ovarian cancer tumors and was more effective at suppressing tumor growth
than chemotherapy.
That
study, «Adolescent
mice, unlike adults, consume more alcohol in the presence of peers
than alone,» was published in Developmental Science in November.
The
study in which
mice given heart transplants survived for longer when forced to listen to Verdi's La Traviata or a selection of Mozart
than when listening to Enya or a monotone could just be down to variety (31 March, p 16).
Philip Laipis of the University of Florida, who has also observed tumors in AAV vector - treated
mice, agrees, at least for
studies using a similarly high dose of AAV to target liver cells, which are more likely
than other cell types to take up the AAV vector.
BORN THIS WAY
Mice born by C - section gained more weight
than those born vaginally, a difference that may be caused by an altered microbiome, a new
study suggests.
«This is the first
study to offer an unbiased profile of novel imprinted genes in a mammal other
than mice,» said lead author Xu Wang, a postdoctoral associate in the laboratory of Andrew Clark, professor of molecular biology and genetics and the
study's senior author.
All three groups of
mice gained weight during the
study, but those in the exercising and shaken groups put on slightly less
than the indolent rodents.
Some
studies have found an increased cancer risk in
mice and rats who were fed acrylamide, but those
studies used doses between 1,000 and 10,000 times higher
than levels that people would be exposed to in food.
Several
studies have shown that, like the
mice in the new
study, babies born by C - section have different compositions of bacteria
than babies born vaginally.
The new
study — published October 18, 2016 in the journal Molecular Psychiatry — combined genetic analysis of more
than 9,000 human psychiatric patients with brain imaging, electrophysiology, and pharmacological experiments in mutant
mice to suggest that mutations in the gene DIXDC1 may act as a general risk factor for psychiatric disease by interfering with the way the brain regulates connections between neurons.
«Stem cells function far differently in
mice than in monkeys,» says biologist Shoukhrat Mitalipov, a senior scientist in the Division of Reproductive and Developmental Sciences at Oregon National Primate Research Center and lead author of the monkey
study.
Gary Wormser, an author of the NYMC
study, meanwhile, counters that single - dose doxy should be more effective in humans
than in
mice because it stays in our blood longer.
Half of the
mice studied, belonging to a genetic line that suffers a form of Crohn's disease were more affected
than the remaining half of
mice, which belong to a healthy
mouse line.
How seriously do you want to take the advice of a much - hyped 2008 Boston University
study declaring that weight lifting can burn more fat
than cardio exercise, when the conclusions were based entirely on sedentary
mice genetically engineered to have bizarrely large muscles?
Randy Nelson, professor and chairman of neuroscience at Ohio State University Wexner Medical Center, has published more
than two dozen
studies done in
mice and hamsters showing that light at night increases body weight and anxiety - like behaviors.
In another
study, his team found that
mice given chow containing trace amounts of arsenic, then exposed to a standard daily dose of ultraviolet light, had higher rates of skin cancers
than mice given untainted chow.
The
study, conducted in
mice, found that exposure to air pollution during the equivalent of the first or second trimester in humans was linked to more negative birth outcomes
than exposure later in pregnancy.
To show why, he pulls out a raft of
study results collected in a large three - ring binder and points to several
studies showing that
mice subjected to stress developed more cancers
than normal
mice.
Miller and colleagues were intrigued by the possibility of designing
studies to lower tau in people, but first they needed to see how the oligonucleotide worked in an animal more similar to people
than a
mouse.
In two independent
studies, people and
mice eating diets low in protein were healthier and tended to live longer
than those eating protein - rich diets.
Their
study showed that
mice without the Y6 gene were smaller, and had less lean tissue,
than normal
mice.
«What we did in this paper is engineer our sensor to be about 15 times better
than a previous version, and then compared it against a blood biomarker in a
mouse model of ovarian cancer to show that we could beat it,» says Sangeeta Bhatia, the John and Dorothy Wilson Professor of Health Sciences and Technology and Electrical Engineering and Computer Science, a member of MIT's Koch Institute for Integrative Cancer Research and Institute for Medical Engineering and Science, and the senior author of the
study.
Out of more
than 110 allegedly well -
studied mouse - eared bat species, there turns out to be one that has been keeping its diet a mystery.
Russell Burke, a biologist at Hoftstra University in Hempstead, N.Y., who has
studied Italian wall lizards in the U.S., says the species would be «at least as good as, and possibly better
than» other bio-indicators, such as
mice and plants.
In the new
study, the researchers found that a fractured arm bone in newborn
mice rapidly realigned through substantial movement of bone fragments rather
than through bone remodeling — a slower process involving the simultaneous formation of new bone on one side and erosion of existing bone on the opposite side.
Fetuses from zinc - deficient
mice in the
study were 38 percent smaller on average
than those from the control group fed a diet with zinc included.