Sentences with phrase «study tumor development»

Not exact matches

Her discovery of radium lead to the development of using X-rays in medicine, and Curie was at the forefront for cancer research, directing the first studies that used radiation to treat tumors.

«There was this initial thought that [circulating tumor cells] are only present at late stage,» says Sollier - Christen, but she notes that in the past year, several studies using more sensitive techniques have found such cells much earlier in tumor development, even before the tumor becomes visible by conventional imaging techniques.

In conclusion, this new study identifies the cellular origin of Pik3ca - induced tumours and reveals that oncogenic Pik3ca activates a multipotent genetic program, setting the stage for future intratumoural heterogeneity at the earliest stage of tumor development.

«Our study identified miR - 182 as a glioblastoma tumor suppressor that reduces the expression of several oncogenes that promote cancer development,» said senior author of the study Alexander Stegh, an assistant professor in the Ken and Ruth Davee department of neurology and of medicine at Northwestern University Feinberg School of Medicine.

An experimental drug in early development for aggressive brain tumors can cross the blood - brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).

For this study, Guttridge, first author David J. Wang, who developed many of the study's concepts, and their colleagues monitored NF - kB activity during tumor development using mouse embryonic fibroblasts and two mouse models.

This year alone, several studies and review articles have posited tentative links between radiation produced by cellular phones and the development of brain tumors.

The study, «The nuclear transport receptor Importin - 11 is a tumor suppressor that maintains PTEN protein,» which will be published online February 13 in The Journal of Cell Biology, suggests that the loss of Importin - 11 may destabilize PTEN, leading to the development of lung, prostate, and other cancers.

«Indeed, when we studied the mice at the embryonic stage, we saw the cells between the muscle fibers expanded explosively and formed tumors early in development,» Hatley said.

«In our study, we demonstrated that alpha - KGDH, when coupled with Gcn5, induces histone succinylation and promotes tumor cell proliferation and tumor development.»

Hockfield came to MIT from Yale University, where she spent 20 years studying brain development and brain tumors and served as provost.

Other studies have found that nutrients in dark, leafy greens may inhibit the growth of tumor cells in breast, skin, lung and stomach cancers and that green tea may thwart cancer development in colon, liver, breast and prostate cells.

This model of dosage amplification during tumor development had not previously been considered,» says Sebastian Müller, lead author of the study.

Previous epidemiological studies have suggested that exposure to pesticides during pregnancy may have a possible role in the development of childhood brain tumors.

By matching normal and cancer cells from a patient, we can now study the differences — what molecules are key to tumor development and growth, and, ultimately, match treatments that might disable this cancer,» says the study's senior investigator, associate professor of pathology, Xuefeng Liu, MD, a member of the Center for Cell Reprogramming (CCR) at Georgetown University Medical Center.

In a previous study, investigators at the Cancer Institute showed that using a vaccine treatment for bladder and breast cancer tumors in laboratory models resulted in a reversal of the traditional immune blockade, as well as the development of tumor specific immunity throughout the body.

«If our findings are confirmed by additional studies, they may open doors to the development of targeted therapies against the tumor subtypes more likely to affect African Americans and potentially help reduce racial disparities in breast cancer.»

In a study published April 26, they suggest this may be a way to treat neuropathies or prevent the development of peripheral nerve sheath tumors.

This study demonstrated that emulsifier - induced alterations in the microbiome were necessary and sufficient to drive alterations in intestinal epithelial cells» homeostasis, which is thought to govern tumor development.

«The current study investigated the impact of dietary sugar on mammary gland tumor development in multiple mouse models, along with mechanisms that may be involved,» said co-author Lorenzo Cohen, Ph.D., professor of Palliative, Rehabilitation, and Integrative Medicine.

Because tumor growth is a concern when cells are reprogrammed to an earlier stage of development, the researchers followed the mice in the Nature Cell Biology study for nearly a year to look for signs of tumor formation and reported finding none.

The study has important implications for human health, and is particularly useful for understanding the changes that occur in cells during the development of the tumors that underlie cancers.

Next, Mao and colleagues developed a way to study how genes and the tumor microenvironment influence cancer development.

Published in the May 1 edition of Cancer Research, the study supports a critical role for IGF - 1R signaling in prostate - tumor development and identifies an important IGF - 1R - dependent growth control mechanism, according to the authors.

The symposium features presentations by Philippa Marrack and John Kappler talking on the T cell repertoire; William Paul on interleukin 4 as a prototypic immunoregulatory cytokine; Timothy Springer on lymphocyte trafficking; Pamela Bjorkman on structural studies of MHC and MHC - related proteins, and Jack Strominger on peptide presentation by class I and II MHC proteins; Thierry Boon on genes coding for tumor rejection antigens, including the first tumor antigen, MAGE - 1; and Philip Greenberg on the modification of T cells for adoptive therapy by retroviral - mediated gene insertion Since then, the symposia series has attracted leading immunologists in the cancer vaccine and antibody fields, providing them with a comprehensive view of the promises and challenges in the development of cancer immunotherapies.

A new study from the German Cancer Research Center has revealed that the entire species of Marmorkrebs originate from a single mother crayfish, in a clonal reproduction that may help shed new light on processes in tumor development.

A Ludwig Cancer Research study has uncovered a key mechanism by which tumors develop resistance to radiation therapy and shown how such resistance might be overcome with drugs that are currently under development.

«With this initiative we will have a unique opportunity to study the development of tumors up close.

$ 1.8 M Supports Cancer Drug Discovery on Commonly Mutated Gene New Brunswick Patch — April 5, 2016 Behavioral Scientist Shares Insights about FDA's Proposed Rule on Banning Tanning Bed Use among Minors News-Medical.net - March 19, 2016 Intervention Program Reduces Caregiver Distress during Hospitalization of Pediatric Stem Cell Transplant Patients News-Medical.net - March 9, 2016 Exploring Genomic Pathways in the Development of Ovarian Cancer GMNews.com - March 2, 2016 Differences in Type of Small Protein may further Elucidate Lung Cancer Risk in African Americans ScienceDaily.com - March 2, 2016 Study Looks at Post-Treatment Resources for Prostate Cancer Patients Transitioning to Survivorship News-Medical.net - February 11, 2016 Drawing the Line on Tanning Bed Use by Teens ScienceDaily.com - December 21, 2015 What Rutgers Study Uncovered about E-Cigarette Use NJBiz.com - December 9, 2015 Identification of Barrier that Prevents Progression of Benign Kidney Tumors to Malignant Disease MedicalNewsToday.com - November, 24, 2015 What is the Color of the Lung Cancer Ribbon?

Fishman, in particular, wanted to advance his studies in oncodevelopmental biology, exploiting proteins involved in embryonic development as tumor markers.

Vescor, advised by its scientific founders White and Kimmelman, whose research has shown inhibition of autophagy can dramatically impact tumor growth in pre-clinical models, will develop small molecule inhibitors of a number of protein targets at critical nodes of the autophagy cascade, perform investigational new drug (IND) enabling studies, and move these into clinical development.

Preclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque Toxicology.

She is registred to the National Order of Biologists in the province of Palermo; collaboration in research project from 2012 to 2015 at the Department of Biopathology and Biotechnology, University of Palermo, focusing the study on the identification of molecules capable to modulate intracellular metabolic pathways for the prevention and treatment of infectious, tumor and degenerative disease, in collaboration with Prof. Angela Santoni, University of Rome; collaboration in research project in 2011 at the hospital «Villa Sofia Cervello» of Palermo to study methods can cure the genetic defect that causes thalassemia through genetic engineering; she studies different mechanisms of the differentiation and the activation of human gammadelta T cells as effector cells of the immune response against cancer and infectious diseases; she investigates about the identification and development of biomarkers of resistance and susceptibility to Mycobacterium tuberculosis infection; Valentina Orlando has published 13 papers in peer reviewed journals and 3 comunications at national and international congress.

Although a large number of genetic alterations that drive the development and progression of many types of cancer have been identified through large - scale research studies, some tumor types have not been deeply characterized.

Transgenic models session Chairs V.Korinek & Z. Kozmik 16.00 Bohumil Fafílek Cell tracking and manipulation in genetically modified mice 16.30 Michaela Krausová Mouse transgenic model to study tumor progression and metastasis in the gut 17.00 coffee break 17.20 Matej Durik Rodent transgenic models of cardiovascular diseases 17.50 Jan Masek The role of Wnt / beta - catenin signaling in neural crest development: an insight from transgenic and knockout mice 19.00 dinner

His lab is studying stem cells during development, homeostasis and tumor development.

Cancer Institute research highlights include innovative studies to develop individualized approaches for treatment and prevention of lung cancer; collaboration between medical and materials science researchers to develop treatments for various types of leukemia using nanotechnology to target only cancer cells; and development of novel therapeutics to treat metastatic melanoma using an approach that regulates the processes leading to tumor development.

My studies of cancer genomes have led to characterization of multiple pediatric and adult tumor types, to development of methods that identify and characterize changes in genomic heterogeneity, to defining acquired resistance mechanisms to targeted therapies and to designing novel, personalized vaccines for individual patients.

Beyond the expansion of the collection of barcoded cell lines for testing larger panels of compounds, next steps will include determining whether PRISM can be used to study the complex interactions between different cell types found within tumors, or to study tumor evolution during cancer development or after cancer treatment.

Technical coordinator of a national convention in France involving industry and universities on the same subject Since 1992: Organizer of a cycle of international conferences on «Heavy scintillators for scientific and industrial applications» First one in Chamonix, France in 1992 (200 participants), 9th one in Winston Salem (NC, USA) in 2007 (300 participants) 1994 - 2007: As Technical coordinator of the CMS electromagnetic calorimeter at the LHC Large Hadron Collider, responsible for the technical development and the mass production of 76» 000 Lead Tungstate crystals (100 tons) 1994 - 2000: Organizer of the development and mass production organization of Lutetium Aluminum perovskite crystals, in particular for PET scanner applications Since 2000: Strong involvement in the development of dedicated breast imaging camera combining several modalities for a multiparametric evaluation of breast tumors (anatomic, structural and functional) Since 2002: Feasibility study and setting - up of an international medical imaging research centre, presently being built in Marseille (Cerimed)

Examples include the study of allelic variation in the human genome and the development of computational methods for the discovery of cancer - associated genes and diagnostic cancer markers using genomic profiles derived from different tumor types.

Study identifies cellular signaling pathway that enables breast cells to resist tissue changes during tumor development and is associated with better prognosis

He was introduced to radiopharmaceutical development as a postdoctoral research associate and then as a staff scientist in the department of radiology at Washington University School of Medicine, where he developed several preclinical imaging agents to study brain tumors, atherosclerosis and Alzheimer's disease.

Studies are focused on the pre-clinical development and design of more effective therapeutic approaches to cancer using mouse tumor model systems.

Nuts: «All varieties are rich in phytosterols, which have been shown in lab and animal studies to inhibit tumor development,» Dixon says.

Numerous studies show that broccoli prevents the development of tumors even up to 60 percent, and that ingridients in brocolli reduce existing tumors up to 75 percent, which is a high number.

The chronically stressed mice had decreased immune function and experienced tumor development significantly earlier than the non-stressed mice.16 Other mouse studies of ovarian cancer showed that chronic stress resulted in increased cancer growth as well as increased angiogenesis, the process with which cancer forms new blood vessels to feed itself nutrients for growth and metastases.17 Chronic stress has also been shown to decrease our body's ability to mount an attack against foreign invaders, including viruses.18 As we know that several viruses can cause cancer (HPV and cervical cancer, and EBV and nasopharyngeal cancer), we can extrapolate that any decrease in immune function could increase cancer risk.

After discussing similar effects in other animal models of cancer and a few studies showing the ability of antioxidants to prevent cancer growth, Campbell concluded that «a pattern was beginning to emerge: nutrients from animal foods increased tumor development while nutrients from plant - based foods decreased tumor development.»

In describing the studies he conducted with his grad students, Campbell says only that a «pattern was beginning to emerge: nutrients from animal - based foods increased tumor development while nutrients from plant - based foods decreased tumor development.»

This tremendous study suggested that pre-cancerous lesions can be used to predict the development of true tumors with 90 - 98 % accuracy.