Sentences with phrase «studying animal models»

Researchers have established a strong genetic component for addictive behaviors through studying animal models, including laboratory mice.

They also studied animal models of LUAD to identify common pathways.

Weaver studied the animal models for as long as 100 days, and found that the islet clusters transplanted with the hydrogel and VEGF developed many blood vessels and engrafted into their new locations.

WASHINGTON (January 16, 2017)-- A synthesized steroid mirroring one naturally made by the dogfish shark prevents the buildup of a lethal protein implicated in some neurodegenerative diseases, reports an international research team studying an animal model of Parkinson's disease.

Not exact matches

Our study in an animal model found that influenza infection leads to an increase in the expression of muscle - degrading genes and a decrease in expression of muscle - building genes in skeletal muscles in the legs.

One might then judge that the exclusion of animal purposes from the study of animal behavior today is an obstacle to progress that requires a changed model.

Earlier studies involving animal models did not translate to humans.

Most of the studies that have produced the craze over PRP have been done using animal models.

Prosecuting would be a «difficult and unworkable task, as little or no evidence is available regarding [the substances»] pharmacological activities in vivo in humans and expert witnesses may be reluctant to extrapolate data from animal models, in silico or in vitro studies,» lecturer in criminal law Amber Marks told the committee.

In 1859, Charles Darwin's evolutionary theory reinforced the conception that animals could serve as models for humans in the study of biology and physiology.

Studies show that these models can accurately predict the ways that new drugs will react in the human body and replace the use of animals in exploratory research and many standard drug tests.

Initial studies conducted by Christine Radtke, new Professor for Plastic and Reconstructive Surgery at MedUni Vienna / Vienna General Hospital, have shown in an animal model that the threads have great potential for nerve and tissue repair.

«By studying how education changes the brain, we can find out how this uniquely human experience induces change in both brain structure and function — something we can not do with animal models.»

Further studies in animal models and patients (with altered TRPM7 channel function) have been initiated, in order to evaluate the efficacy and safety of magnesium as a therapeutic for this disease.

The findings are interesting, says René Hen, a neuroscientist who studies depression at Columbia University in New York, but «animal models of depression are very imperfect.»

In medicine today, physician - scientists and basic scientists supplement support for their research by applying their expertise part time to develop and test commercial products.1 In my own field, vision science, university - based researchers obtain additional funding through clinical and electrophysiologic studies, pathology, imaging, biochemistry, and animal model development performed for pharmaceutical and instrument companies.

By studying human cancer cells and animal models of cancer in the lab, our researchers have shown that loss of PTEN leads to high levels of PI (3,4) P2, which could result in hyperactivation of AKT.

«Chronic inflammation of the intestine is thought to be caused by abnormal interactions between gut microbes, intestinal epithelial cells and the immune system, but so far it has been impossible to determine how each of these factors contribute to the development of intestinal bowel disease,» said Hyun Jung Kim, Ph.D., former Wyss Technology Development Fellow and first author on the study, speaking about the limitations of conventional in vitro and animal models of bacterial overgrowth and inflammation of the intestines.

Hackett said, «Studies of human immunology are usually not the first choice for research in basic immunology, but it is very important now to understand how humans differ from animal models.»

Senior author Byungkook Lim, an assistant professor in the Neurobiology Section, said the results require much more study and evaluation to be applied to humans with depression, but the new research in animal models provides solid grounding.

A raft of studies in laboratory animals, molecular models and cancer patients suggest that pain drugs given during and after cancer surgery stimulate the growth and spread of certain tumors.

The study of these highly unusual but devastating prion diseases has to date been thwarted by a lack of animal models that faithfully mimic the disease processes in humans.

Ellen Heber - Katz, a scientist at The Wistar Institute in Philadelphia, used to study autoimmunity — that was until she noticed something strange in the mice she was using to model lupus: The small holes that she had poked in their ears to distinguish the animals from one another kept closing.

To find out what impact this might have on a flu epidemic, Earn and his colleagues turned to a 1982 study which showed that ferrets, a common animal model for human flu, produced more seasonal flu virus if their fevers were lowered either with painkillers or by having their fur shaved off.

As for the Lund researchers, the method provides a tool for studying how neurons cooperate inside a healthy brain and in animal models with different neurological diseases.

A new study by scientists from the Florida campus of The Scripps Research Institute (TSRI) found no evidence of increased aggressive behavior toward strangers in an animal model of the condition.

Our study goes a long way towards validating the usefulness of this animal model and provides enormous support for its use in human illnesses.

A new study has found that stem cell therapy can reduce lung inflammation in an animal model of chronic obstructive pulmonary disease (COPD) and cystic fibrosis.

Next they intend to perform studies in animal models and in solid tumors.

One 2014 study based on modeling animal movement found that increasing vehicle density on existing roads, rather than adding more roads with lower density, resulted in fewer wildlife fatalities.

Nath's team is currently developing an animal model of Nodding syndrome to further study the disease and test potential therapies.

«We know that urate has neuroprotective properties in animal models, and an unusual convergence of human studies suggested its possible use as a disease - modifying strategy in Parkinson's; so the positive results of this trial are very encouraging.»

In this study, the Hiroshima University researchers developed an animal model using severely immunodeficient mice whose livers were partially populated with human cells, in order to reconstruct elements of the human immune system.

The study took advantage of an important large animal model of SMA, the SMA piglet developed by the research group.

Nadeau also studies the potential impacts of climate change on species around the globe, using modeling, field observation and experiments to predict where species are most vulnerable and determine how conservation groups can best mitigate the negative impacts of climate change on animal populations.

The journal provides cutting - edge research including results from animal models that are likely to apply to patients, studies in human tissue that provide new information about therapies or disease, and innovative reports of drug discovery and development.

While mouse models have traditionally been used in studying the genetic disorder, Deng said the animal model is inadequate because the human brain is more complicated, and much of that complexity arises from astroglia cells, the star - shaped cells that play an important role in the physical structure of the brain as well as in the transmission of nerve impulses.

The study — which looked at the action of Substance P within nerve cells in the lab and in animal models — focused on acute pain, but Professor Gamper aims to look at its role within chronic pain as well.

Whales and dolphins could provide a useful model for research into such impacts, largely because their sounds are relatively easy to study: They are among the loudest noises any animal has ever made, reaching as much as 188 decibels in the blue whale.

Because the researchers found that CTLA4Ig was effective in suppressing hepatitis in this study, they suggest that CTLA4Ig should be among the therapeutic options investigated further as a potential therapy for patients with severe acute hepatitis B. To this end, this animal model is useful for virological and immunological analysis of HBV infection.

«The study of this type of tumours has been problematic up to now due to the lack of cell models and the appropriate animal models,» says CNIC researcher Juan Carlos Ramírez, who adds that the difficulty of generating these chromosomal translocations had limited the availability of cells with this mark of the disease.

«Despite the prevalence of abnormal sleep patterns in PD, very few studies to date have outlined sleep disturbances in animal models of PD,» says Sarah M. Rothman, PhD, a researcher with the National Institute on Aging, in Baltimore, MD..

«This study highlights the importance of confirming the validity of potential biomarkers in a relevant, large animal model and will be useful in the design of future clinical trails,» commented lead investigator Stephen J. Kolb, MD, PhD, Associate Professor, Department of Neurology and Biological Chemistry & Pharmacology, The Ohio State University Wexner Medical Center, Columbus, OH.

This finding is in accordance with earlier animal model studies, which have shown that physical activity increases the amount of growth factors in the brain and improves synaptic plasticity.

The potential strategy — which targets metabolic pathways that are active only during intestinal inflammation — prevented or reduced inflammation in a mouse model of colitis while exerting no obvious effect in control animals with healthy, balanced bacterial populations, said Dr. Sebastian Winter, Assistant Professor of Microbiology and co-corresponding author of the study published online today in Nature.

«Most previous research into ways of delaying the onset of HD symptoms have focused on studying the mutant protein in cells or in animal models, but the relevance of abnormalities in those systems to what actually happens in patients remains a huge assumption,» says James Gusella, PhD, director of the Center for Human Genetic Research (CHGR) at Massachusetts General Hospital (MGH), corresponding author of the Cell paper.

Harding also argues that because rodent studies suggest that these animals do lose neurons to alcohol, they may be unreliable models for the human hippocampus.

The next step will be to study the effect of the AcrA - PPMO in animal models.

The brochures contain information about toxicology, pharmacology, and animal safety studies used to determine the potential risk a particular therapy may pose to humans, but they also include efficacy studies done in animal models to demonstrate a therapy's potential benefit.

In the new study, Professor Pisani and colleagues used cutting edge statistical techniques (Posterior Predictive Analyses) to test whether the evolutionary models routinely used in phylogenetics can adequately describe the genomic datasets used to study early animal evolution.