Shane Mayack was a postdoc in the lab of Amy Wagers at Harvard University's Joslin Diabetes Center,
studying blood stem cells.
He says the structure could also offer a new way of
studying blood stem cells and how blood disorders arise.
Not exact matches
Now, in a
study published February 13 in Science Signaling, Lin's team discovered that a chemical compound that activates ATF6 also converts patient - derived
stem cells into
blood vessels.
This fits with
studies we've conducted in the past in which we found that the gene primes
blood stem cells for leukaemic transformation.»
«
Blood stem cells
study could pave the way for new cancer therapy.»
In a
study recently published in the journal Nature Biotechnology, HSCI researchers at Harvard University and Massachusetts General Hospital (MGH), in collaboration with Boston Children's Hospital and Dana Farber Cancer Institute, have developed a non-toxic transplantation procedure using antibodies to specifically target
blood stem cells in mice, an approach they hope will make
blood stem cell transplants for these patients far less toxic.
In this
study, researchers took cells from patients with
blood cancer MDS and turned them into
stem cells to
study the deletions of human chromosome 7 often associated with this disease.
«Proper
blood cell production is dependent on functioning hematopoietic
stem and progenitor cells that are destroyed during conditioning procedures for transplantation or following bone marrow injury,» said the
study's first author Kevin A. Goncalves, who performed this research as part of his PhD
studies in cellular and molecular physiology at the Sackler School.
Around 2000, then - postdoc Wagers and other researchers in Irving Weissman's and Thomas Rando's labs at Stanford revived the method, known as parabiosis, to
study the fate of
blood stem cells and muscle cells.
Some of the first evidence for cancer
stem cells came from
studies of leukemia in the 1990s, which showed that only a small subset of the cancerous
blood cells could propagate the disease in mice.
Earlier mouse
studies by Li and his collaborators had indicated that the expression of several imprinted genes changes as hematopoietic
stem cells embark on their journey from quiescent reserve cells to multi-lineage progenitor cells, which form the many highly specialized cell types that circulate within the
blood stream.
Dr Mohamed Elrayess, from ADLQ, said: «In this
study we have shown that the impaired ability of fat
stem cells to store excess fat was partially due to increased levels of the inflammatory marker interleukin - 6 in the
blood.
A September 2002 follow - up
study found no evidence for widespread transdifferentiation of
blood - forming
stem cells in brain, liver, kidney, gut and other tissues.
A
study published January 4th in Cell
Stem Cell demonstrates that a gene therapy approach can lead to the long - term survival of functional beta cells as well as normal
blood glucose levels for an extended period of time in mice with diabetes.
The
study was published in the December issue of Experimental Hematology, the official publication of the Society for Hematology and
Stem Cells, and also highlighted in the journal's editorial due to its significance in the biology and treatment of
blood cancer.
The five - year
study, led by UCLA Jonsson Comprehensive Cancer Center member Dr. Jianyu Rao, measured the ability of TSY - 1 to affect telomerase activity in cancer cells lines, including one known as HL - 60, as well as normal peripheral
blood mononuclear and hematopoietic
stem cells.
A new test may reveal which patients will respond to treatment for graft versus host disease (GVHD), an often life - threatening complication of
stem cell transplants (SCT) used to treat leukemia and other
blood disorders, according to a
study led by researchers at the Icahn School of Medicine at Mount Sinai and published online today in the journal Lancet Haematology and in print in the January issue.
This rejuvenated the
stem cells in the bone marrow of the older mice that replenish their
blood, and led to a wave of
studies comparing the
blood of old and young mice to try and identify the youth - giving substance.
The team could establish the number of white
blood cell - generating
stem cells by
studying the pattern of mutations found within the
blood cells.
The results make it clear, says
stem - cell biologist Amy Wagers, who headed the
study, that these hematopoietic
stem cells can do a lot for
blood diseases but not for diseases affecting other kinds of cells.
«The significance of this
study expands beyond the limits of AHDS research, to the possibility of
stem cell modeling the
blood - brain barrier component in many other neurological diseases,» Vatine says.
In the
study, USC
Stem Cell researcher Casey Brewer and colleagues in the laboratory of Rong Lu found that transplantation dose affects the behavior of blood - forming stem cells in bone marrow — called hematopoietic stem cells, or H
Stem Cell researcher Casey Brewer and colleagues in the laboratory of Rong Lu found that transplantation dose affects the behavior of
blood - forming
stem cells in bone marrow — called hematopoietic stem cells, or H
stem cells in bone marrow — called hematopoietic
stem cells, or H
stem cells, or HSCs.
In 2005, Rando and his colleagues published a
study in Nature showing that
stem cells in several tissues of older mice, including muscle, seemed to act younger after continued exposure to younger mice's
blood.
The new Mount Sinai
study reveals how loss of a protein called Sirtuin1 (SIRT1) affects the ability of
blood stem cells to regenerate normally, at least in mouse models of human disease.
Early animal
studies have shown that
stem cells isolated from umbilical cord
blood can stimulate cells in the spinal cord to regrow their myelin layers, and in doing so help restore connections with surrounding cells.
In a
study recently published in the journal Scientific Reports, researchers in USF's Center of Excellence for Aging and Brain Repair say the results of their experiment are an early step in pursuing
stem cells for potential repair of the
blood - spinal cord barrier, which has been identified as key in the development of ALS.
According to a new
study, these «cancer
stem cells» reside in
blood vessels.
Professor Haase also
studies the relevance of genetic polymorphisms of DNA - repair and detoxification genes for AML and MDS, the relevance of iron overload for
stem cell functions in MDS, and the establishment of FISH analysis of CD34 + cells from the peripheral
blood as a diagnostic tool for screening and monitoring in patients with MDS.
Dr. Robert A.J. Signer, a postdoctoral research fellow in Dr. Morrison's laboratory and first author of the
study, realized that this reagent could be adapted to measure new protein synthesis by
stem cells and other cells in the
blood - forming system.
In this
study, prior to giving intensive BEAM chemotherapy (which uses carmustine, etoposide, cytarabine, and melphalan), researchers collected
stem cells from each patient's
blood.
Through the UCSD Clinical Cardiovascular Cell Therapy program, Dib and collaborating cardiology faculty plan to conduct clinical
studies in a number of areas, including the effectiveness of adult
stem cell transplant as a treatment for congestive heart failure; as a way to minimize heart damage after a heart attack; and in the formation of new
blood vessels (angiogenesis) to increase
blood flow to the heart for patients experiencing chest pain.
Muscle damaged by heart attacks can be repaired by an injectable gel that forms scaffolding, attracting
stem cells and
blood vessels in a
study that may lead to a new method for reducing heart failure.
Working with the research group led by Vijay G. Sankaran, M.D., Ph.D., of Boston Children's Hospital and the Broad Institute, Rajiv K. Khajuria, a doctoral student at Charité's Berlin - Brandenburg School for Regenerative Therapies,
studied the molecular processes involved in the differentiation of
stem cells and their development into mature
blood cells.
«Enhanced cord
blood stem cell transplants safe in long - term
studies.»
In the second
study, a team led by Shahin Rafii at Weill Cornell Medicine in New York City used adult mouse cells as their starting material, and then guided them through several steps — including exposure to some of the same gene - activating proteins — to create mature
blood stem cells in a petri dish.
An innovative experimental treatment for boosting the effectiveness of
stem - cell transplants with umbilical cord
blood has a favorable safety profile in long - term animal
studies, report scientists from Dana - Farber Cancer Institute, Beth Israel Deaconess Medical Center (BIDMC), and Children's Hospital Boston (CHB).
In a previous
study by the same group 78, autologous culture - expanded MSC were infused to breast cancer patients to investigate whether MSC would enhance the engraftment of peripheral
blood stem cells after myeloablative therapy.
The findings may even have implications for
studying glioblastoma, a common brain cancer whose ability to grow, migrate and hack into the brain's
blood supply appears to rely on a pattern of gene activity similar to that now identified in these neural
stem cells.
In an NIH - funded
study, scientists were able to direct human
stem cells to form networks of tiny
blood vessels that can connect to the existing circulation in mice.
Spreadsheet of 23 parameters for controlled
studies treating cerebral palsy with
stem cells from cord
blood or bone marrow.
Her
studies of the
stem cells in bone marrow and their requirements for successful growth have contributed to advances in transplantation techniques that have saved the lives of patients with leukemia and other
blood cancers.
To keep up to date with all the continuing
studies that hope to boost the regenerative potential of cord
blood, stay tuned to the
Stem Cells Portal.
Until now,
blood cell production was ascribed solely to bone marrow, but
studies on mice have found that the majority of the body's platelets are produced in the lungs, as is a backup reservoir of
blood stem cells that can step in when those in the bone marrow run dry.
To
study blood development, researchers typically purify
blood stem cells from the bone marrow of mice and transplant them into mice exposed to radiation, thus creating a tractable experimental system.
Doctors at Okyanos utilize a specifically developed Okyanos protocol for opening up the
blood brain barrier to help deliver
stem cells directly to the brain; a technique that has been proven effective in independent
studies This enables doctors to target your
stem cells inside the brain to re-establish
blood flow and repair damaged nerve cells (neurons) as well as target the restoration of myelin, halting the future progression of symptoms.
In a
study using human muscle tissue, scientists in Children's
Stem Cell Research Center - led by Johnny Huard, PhD, and Bruno Péault, PhD - isolated and characterized stem cells taken from blood vessels (known as myoendothelial cells) that are easily isolated using cell - sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage ce
Stem Cell Research Center - led by Johnny Huard, PhD, and Bruno Péault, PhD - isolated and characterized
stem cells taken from blood vessels (known as myoendothelial cells) that are easily isolated using cell - sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage ce
stem cells taken from
blood vessels (known as myoendothelial cells) that are easily isolated using cell - sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage cells.
A new
study demonstrates that normal and leukemic
blood stem cells fight for the same niche with consequences for cancer treatment and transplantation.
Utilizing sophisticated genetically engineered mouse models, we will
study how these conserved longevity pathways regulate the homeostasis and aging of adult
stem cells, including hematopoietic
stem cells, the adult
stem cells that sustain all
blood lineages throughout life.
The
study found that while peripheral
blood stem cells may reduce the risk of graft failure, bone marrow may cut the chances of developing chronic graft - versus - host disease (GVHD), a complication that is frequently debilitating.