Sentences with phrase «studying cells in a dish»

One benefit of studying cells in a dish, rather than studying actual people, is that you can limit variables, Goniewicz says.

Not exact matches

WASHINGTON — Tiny orbs of brain cells swirling in lab dishes may offer scientists a better way to study the complexities of the human brain.

In the meantime, researchers could use the cells to study neurological and psychiatric disorders in Petri disheIn the meantime, researchers could use the cells to study neurological and psychiatric disorders in Petri dishein Petri dishes.

So far, researchers have mostly turned on genes with CRISPRa in cells growing in lab dishes, says Charles Gersbach, a biomedical engineer at Duke University not involved in the new study.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

In addition to helping understand disease by providing more powerful study models, «what this technology would allow you to do is reprogram a skin cell, for example, from a Parkinson's patient... into a pluripotent cell and then in a petri dish redirect that cell into... a neuron» to treat that patienIn addition to helping understand disease by providing more powerful study models, «what this technology would allow you to do is reprogram a skin cell, for example, from a Parkinson's patient... into a pluripotent cell and then in a petri dish redirect that cell into... a neuron» to treat that patienin a petri dish redirect that cell into... a neuron» to treat that patient.

That allowed tumor cells to survive gemcitabine treatment in lab dishes and mouse studies, Leore Geller of the Weizmann Institute of Science in Rehovot, Israel, and colleagues discovered.

Matteo Boretto, the first author on this study, commented that «we were very excited to see that we could not only robustly grow and amplify endometrial tissue in a dish, but that the tiny structures were also able to reproduce normal responses of the endometrium to hormones: oestrogen makes the tissue thicken, progesterone then induces maturation including folding (see picture), and subsequent removal of both hormones mimics the cell shedding of the menstrual period.»

They used mice and cartilage cells in a dish to study one mutant form of IDH that is identified only in cartilage cells.

One metabolite featured in the study is cholesterol sulfate, which was found to be used up during osteogenesis on a rigid matrix and in turn could be used to convert stem cells into bone - like cells in a dish.

The disease model, described in a new study by a UC San Francisco - led team, involves taking skin cells from patients with the bone disease, reprogramming them in a lab dish to their embryonic state, and deriving stem cells from them.

«To date, there has been no systematic means of assessing the fidelity of cellular engineering — to determine how closely cells made in a petri dish approximate natural tissues in the body,» says George Q. Daley, MD, PhD, Director of the Stem Cell Transplantation Program at Boston Children's and senior investigator on both studies.

So instead of studying the whole animals, he began isolating single nerve cells from the mole rats and investigating them in lab dishes to track the molecular basis of the rodent's pain insensitivity.

Their study, published in the ACS journal Chemical Research in Toxicology, found that triclosan, as well as another commercial substance called octylphenol, promoted the growth of human breast cancer cells in lab dishes and breast cancer tumors in mice.

The investigators studied application of various doses of a common PBDE flame retardant on human adrenal cells in culture dishes and compared the effects with those of only the vehicle, the inactive substance used to deliver the chemical.

However, the usefulness of these studies greatly depends on how accurately these cancer cells grown in a dish represent human tumors.

The encouraging news is that turning stem cells into auditory neurons can be controlled — at least in a Petri dish, said Kelvin Y. Kwan, senior author of the study and an assistant professor in the Department of Cell Biology and Neuroscience in the School of Arts and Sciences.

Previous evidence for a breast cancer link has been mixed — one study found increased risk in women exposed before age 14, whereas others found no association — but in a lab dish, DDT has been shown to activate the HER2 gene in human breast cells, which is expressed in some breast cancers.

In a study published today (Aug. 4, 2016) in Cell Reports, senior author Chapman, first author Bomba - Warczak and colleagues present clear evidence that toxin is moving between neurons in a lab disIn a study published today (Aug. 4, 2016) in Cell Reports, senior author Chapman, first author Bomba - Warczak and colleagues present clear evidence that toxin is moving between neurons in a lab disin Cell Reports, senior author Chapman, first author Bomba - Warczak and colleagues present clear evidence that toxin is moving between neurons in a lab disin a lab dish.

The genes are likely to be expressed when cells differentiate into neural crest lineages, such as neurons or Schwann cells, thereby enabling researchers to study the disease in a dish.

While some seek to use iPSCs as replacements for cells compromised by disease, the new Mount Sinai study sought to determine if they could serve as an accurate model of genetic disease «in a dish.»

The practical implications could be very significant, from studying genetic diseases in a dish to generating possible regenerative cures from the patient's own cells.

In their recent study, the UCSF team reports the discovery that a class of commonly prescribed Type - 2 diabetes drugs, called TZDs (thiazolidinediones, such as Actos and Avandia), promoted the conversion of white fat cells into brown (in mice and culture dishes) by stabilizing the PRDM16 proteiIn their recent study, the UCSF team reports the discovery that a class of commonly prescribed Type - 2 diabetes drugs, called TZDs (thiazolidinediones, such as Actos and Avandia), promoted the conversion of white fat cells into brown (in mice and culture dishes) by stabilizing the PRDM16 proteiin mice and culture dishes) by stabilizing the PRDM16 protein.

But making chimeras with human organs whose development can be studied is more likely to succeed than the technique researchers have been trying for years: coaxing stem cells growing in lab dishes to become three - dimensional, functional tissues and organs.

Zhang has been using a different approach — studying diseased human cells in lab dishes.

In the second study, a team led by Shahin Rafii at Weill Cornell Medicine in New York City used adult mouse cells as their starting material, and then guided them through several steps — including exposure to some of the same gene - activating proteins — to create mature blood stem cells in a petri disIn the second study, a team led by Shahin Rafii at Weill Cornell Medicine in New York City used adult mouse cells as their starting material, and then guided them through several steps — including exposure to some of the same gene - activating proteins — to create mature blood stem cells in a petri disin New York City used adult mouse cells as their starting material, and then guided them through several steps — including exposure to some of the same gene - activating proteins — to create mature blood stem cells in a petri disin a petri dish.

«By studying the patients» heart cells in a dish, we were able to figure out why their hearts were not pumping properly,» explained Srivastava.

In a dish, DIPG cells that survived initial doses of panobinostat developed some resistance to the drug, the study found.

The applications could be very significant, from studying genetic diseases in a dish to generating possible regenerative cures from the patient's own cells.

As a result, in 2009, a study led by Monje was the first in the world to report establishment of a line of DIPG cells that could be studied in a dish.

Human tissues exposed to either drug for one week in a dish had reduced numbers of cells that give rise to sperm and eggs, called germ cells, the study found.

The cell types involved in diabetes — the beta and immune cells — are being studied in the culture dish, as well as transplanted into lab animals.

can be rapidly grown in dishes, and because its cell divisions can be individually tracked through a precisely defined ballet, it's another good choice for studying development.

In a study published earlier this year, the same Belmonte and Gage lab team demonstrated that a few ES cells in a culture dish tended to lose stemness and evolve into muscle cell precursors, most likely goaded by a muscle differentiation factor known as BMIn a study published earlier this year, the same Belmonte and Gage lab team demonstrated that a few ES cells in a culture dish tended to lose stemness and evolve into muscle cell precursors, most likely goaded by a muscle differentiation factor known as BMin a culture dish tended to lose stemness and evolve into muscle cell precursors, most likely goaded by a muscle differentiation factor known as BMP.

These single - celled microbes share many characteristics with human cells, but they can be rapidly grown in great numbers in a flask or petri dish, and they have a life cycle and genome that make their genetics easier to study.

It is now almost routine to grow skin cells from a patient with, say, a neurological disease; turn them into pluripotent cells in a Petri dish; convert the cells into nerve cells to study the disease process; and contemplate using the cells to repair the same patient's damaged brain.

For example, in this apple study, they also measured the ability of apple extracts, from both peeled and unpeeled apples, to suppress the growth of human cancer cells growing in a petri dish, compared to control.

There are a number of specific compounds in plant foods that look promising, but that's based on in vitro studies like this, where they basically just drip some plant compound on bone cells in a petri dish and see a boost in bone builder cells, or a drop in bone eater cells.

There are also petri dish studies that suggest gamma oryzanol may help lower cholesterol, and along with other compounds found in the rice bran, which is what makes brown rice brown, may inhibit human cancer cell growth through antioxidant means, anti-proliferative and pro cancer cell suicide mechanisms, immune system modulation, and increasing barrier protection, but again this is all just in test tubes, not people.