Sentences with phrase «studying complex diseases»
GWAS are ideally suited for studying complex diseases as a way of approximating and locating the genetic contribution.
https://www.brightfocus.org/ Not exact matches
After residency, Dr. Chandra spent 5 years studying with, and working with, Dr. William Lee Cowden, MD a leading expert in the treatment of chronic Lyme disease and other complex medical conditions.
The first environment - wide association study borrows from genomics to reveal new leads in major complex diseases
These basic principles can be applied to the study of more complex mental illnesses such as schizophrenia, bipolar disorder or Alzheimer's disease.
They are of high interest for the study of complex diseases that have no clear mutational cause,» said Yamashita, who added the alanine threonine substitution was a rare variant.
Scientists have shifted from studying single molecules to investigating large complexes of interacting biological macromolecules involved in processes such as metabolic pathways, gene expression, and development of disease.
Today in Cell and associated journals, 24 research studies from the landmark BLUEPRINT project and IHEC consortia reveal how variation in blood cells» characteristics and numbers can affect a person's risk of developing complex diseases such as heart disease, and autoimmune diseases including rheumatoid arthritis, asthma, celiac disease and type 1 diabetes.
In conclusion, these results highlight the importance of large - scale genetic studies to better characterize complex diseases.
Highlighting the collaboration, Hughes said, «This study demonstrates how the synergy between experimental and computational approaches can help unravel the nature of a complex disease such as HD.»
The authors conclude: «The findings from this large prospective study show that the association between body size and prostate cancer is complex and varies by disease aggressiveness; men who have greater adiposity have an elevated risk of high grade prostate cancer and prostate cancer death.»
«Study of complex genetic region finds hidden role of NCF1 in multiple autoimmune diseases.»
Stanford University researchers studying how the brain controls movement in people with paralysis, related to their diagnosis of Lou Gehrig's disease, have found that groups of neurons work together, firing in complex rhythms to signal muscles about when and where to move.
«Gene sequencing has opened a huge door to how complex these communities are,» says Patrick Seed, a Duke pediatrician specializing in infectious disease, who with biologist Rob Jackson is a lead investigator of the premature infant study.
The study has produced more than 20 publications examining a range of complex human conditions, including cardiovascular disease, breast and lung cancer, and type I and II diabetes.
There's also a more recent foray into the study of complex biological systems, from the population - wide dynamics of a disease outbreak to the way human bodies align their functions to a biological clock.
«This study convincingly shows that mild trauma has a role in increasing the risk of dementia and sheds light on the more complex relationship between medical and psychiatric diseases with TBI in the development of the future risk of dementias.
«The specific macromolecular complex investigated in this study has therapeutic implications not only for addiction, but also for Parkinson's disease and schizophrenia,» said Dr. Sergi Ferré, who led the team of scientists.
«Thus, it is clear that further studies must investigate an increasingly complex matrix of cell types and conditions to fully understand the role of human genetic variation in disease.»
«Investigators create complex kidney structures from human stem cells derived from adults: New technique offers model for studying disease, progress toward cell therapy.»
«It has shown that the value of sequencing a few thousand individuals is high for highly penetrant, rare diseases, but that for complex traits and diseases much larger sample sizes will be required in future studies.
As efforts continue to characterise the genetic underpinnings of complex diseases, the data and results of this study are expected to enable the next wave of discoveries.
The study highlights the complex links between agriculture and disease, says Charles Godfray, a biologist at the University of Oxford in the United Kingdom.
«If human organs on chips can be shown to be robust and consistently recapitulate complex human organ physiology and disease phenotypes in unrelated laboratories around the world, as suggested by early proof - of - concept studies, then we will see them progressively replace one animal model at a time.
«To better understand what happens when cells are overwhelmed with fat during obesity, we first have to understand how the system normally deals with fluctuations in lipids,» said Tobias Walther, professor of genetics and complex diseases at Harvard Chan and co-senior author of the study.
Some Mendelian disorders are known to predispose patients to certain complex diseases, but these co-occurrences have thus far only been studied on a small - scale basis.
This essentially gives us «barcodes» of specific gene loci, which we can use to help untangle the complex genetics of complex diseases,» said Andrey Rzhetsky, PhD, professor of genetic medicine and human genetics at the University of Chicago, who led the study.
In a comprehensive and complex molecular study of blood samples from Ebola patients in Sierra Leone, published in Cell Host and Microbe, a scientific team led by the University of Wisconsin - Madison has identified signatures of Ebola virus disease that may aid in future treatment efforts.
They studied these correlations in 65 complex diseases affecting almost every system in the body, including arthritis, depression and lung cancer, and in 95 Mendelian disease groups (representing 213 disorders).
Called the HapMap, this catalog has made the use of SNPs to track down genes involved in complex diseases — so - called genome - wide association studies — a reality.
«Studying diseases with complex genetics is extremely challenging.
The research, made possible by the availability of high - resolution data in space and time on veterinarian movements in the study area, shed light on the actual significance of operator movements in disease spread, a still poorly understood topic due to the highly diverse and complex nature of such movements and to privacy issues in data collection.
But studying how the cells of complex tissues like the mammary gland self - organize, make decisions as groups, and break down in disease has been a challenge to researchers.
MEGENA (for Multiscale Embedded Gene Co-expression Network Analysis) projects gene expression data onto a three dimensional sphere, allowing scientists to study hierarchical organization patterns in complex networks that are characteristic of diseases such as cancer, obesity, and Alzheimer's.
The researchers said the work demonstrates that, in fact, multi-tissue, multi-individual data can be used to identify the mechanisms of gene regulation and help to study the genetic basis of complex diseases.
This work illustrates how the study of inbred canine populations can provide new insights into the genetic underpinnings of complex disease, bridging the gap between small rodent models and humans.
«We can't start talking about improved treatments for Maya because diabetes is a very complex disease, involving lots of yet unknown risk factors, says Teresa Tusié Luna, a human geneticist who studies diabetes at the Salvador Zubirán National Institute of Health Sciences and Nutrition in Mexico City.
According to Halassa, the new research sets the stage for ever more detailed studies on the complex behavior involved in how the mammalian brain pays attention to what's important, and especially how those neural circuits are broken in cases of attention - deficit diseases, such as ADHD, autism, and schizophrenia.
A $ 1.6 million effort to study the complex mechanisms of the disease and identify existing drugs that might be able to be used for Alzheimer's treatment or prevention, led by Eric Schadt of Icahn School of Medicine at Mount Sinai in New York City.
The genetic causes of Hirschsprung's disease are complex, making it an interesting case study for researchers like Aravinda Chakravarti, Ph.D., a professor in the Johns Hopkins University School of Medicine's McKusick - Nathans Institute of Genetic Medicine.
Will you now use family genome sequencing to study other, more common and complex diseases?
«The study is exciting because it suggests that improving ER function before the onset of disease could reduce T1D incidence,» said lead author Feyza Engin, research associate in the HSPH Department of Genetics and Complex Diseases.
More importantly, says Greenberg, the BRCC36 - KIAA0157 complex may represent an attractive drug development target for inflammatory diseases — an effort that should be aided immeasurably by the detailed structural information this study provides.
«This study makes important observations about home life that may affect susceptibility to complex diseases later on in life.»
«This new study shows that complex I deficiency is, in fact, a global phenomenon in the brain of persons with Parkinson's disease, and is found indiscriminately in both affected and healthy brain regions.
So far, «genome - wide association studies» have identified variant DNA sequences showing statistical association with these and other complex diseases, but demonstrating a mechanistic role for these variants has proven elusive.
We'd recently published some high profile studies of AMD, cleft lip, metabolic syndromes, and other phenotypes that demonstrated our ability to unravel common complex disease.
In the last decade, genome - wide association studies (GWAS) enabled by cheap, high - throughput SNP genotyping have identified thousands of loci that influence disease susceptibility, quantitative traits, and other complex phenotypes.
Many numbers have been tossed around as the minimum requirement to comprehensively study the genetic architecture of complex disease.
[NEWS, 4 June 2013] Protein microarrays, representing more than one third of all human proteins, provide a unique possibility to study complex autoimmune diseases, such as multiple sclerosis (MS).
A decade into the era of well powered and reproducible genome wide association studies, one thing is clear: many complex diseases are extremely polygenic, with thousands or perhaps tens of thousands of segregating variants contributing to variation in risk among individuals.