Sentences with phrase «studying disease development»

As a result, they contain a complete set of the genes that resulted in that disease — representing the potential of an almost perfect disease model for studying disease development, new drugs and treatments.

Not exact matches

Amgen Executive Vice President of Research and Development Sean Harper said the study was designed to explore Kyprolis dosing regimens, noting that the the trial did not meet its goal in improving progression - free survival versus Velcade in patients who had not yet been treated for the disease.

However, development costs will likely rise, however, as the «DepoVax pipeline expands into other medical markets beyond oncology and infectious disease» and «existing programs advance into more substantive Phase 2 studies, perhaps as early as FY H2 / 18.»

This current study conducted in Nigeria looked at the pathogenic role of cadmium (Cd) and its exposure in the induction of dyslipidemia implicated in the development and increasing incidence of cardiovascular diseases, and explored whether polyphenolics isolated from virgin coconut oil (VCO) could prevent Cd - induced dyslipidemia.

Several studies also indicate a connection between lack of breastfeeding and later development of Crohn's disease and ulcerative colitis, two serious inflammatory bowel diseases.

Studies show that Omega - 3 can reduce cardiovascular disease, improve neurological development and function, and strengthens immune function.

«In summary, the evidence from these conflicting studies, in balance, does not allow one to conclude that there is a strong relationship between the timing of the introduction of complementary foods and development of atopic disease.

An older study in the Archives of Disease of Childhood found that prolonged crying was associated with adverse cognitive development.

There are many research studies indicating that breast fed baby's are protected from a large array of childhood diseases and have better brain development.

Research in the United States, Canada, Europe, and other developed countries, among predominantly middle - class populations, provides strong evidence that human milk feeding decreases the incidence and / or severity of diarrhea,1 - 5 lower respiratory infection,6 - 9 otitis media,3,10 - 14bacteremia, 15,16 bacterial meningitis, 15,17 botulism, 18 urinary tract infection, 19 and necrotizing enterocolitis.20, 21 There are a number of studies that show a possible protective effect of human milk feeding against sudden infant death syndrome,22 - 24insulin - dependent diabetes mellitus,25 - 27 Crohn's disease, 28,29 ulcerative colitis, 29 lymphoma, 30,31 allergic diseases,32 - 34 and other chronic digestive diseases.35 - 37 Breastfeeding has also been related to possible enhancement of cognitive development.38, 39

less than or equal to lamivudine Acquired Immune Deficiency Syndrome Antiretroviral therapy, usually means 1 - 2 drugs, used in early studies Antiretroviral zidovudine (also known as ZDV) Breastfeeding Baby Friendly Hospital Initiative Breastfeeding and HIV International Transmission Study Combined antiretroviral therapy Centers for Disease Control and Prevention Deoxyribonucleic Acid Exclusive Breastfeeding Enzyme Linked Immunosorbent Assay Food and Agrigulture Organization Fixed dose combination ART, e.g., lamividine, stavudine, and nevirapine Highly Active Antiretroviral Therapy, 3 or more drugs for more effective treatment used in later studies Human Immunodeficiency virus International Atomic Energy Agency Infant feeding Infant and young child feeding Lopinavir cubic millimetre Mother - to - Child Transmission of HIV Non-governmental organization Nevirapine Polymerase Chain Reaction People Living with HIV Prevention of Mother - to - Child Transmission Replacement Feeding Ritonavir Ribonucleic acid, one of the three major macromolecules (along with DNA and proteins) that are essential for all known forms of life single dose NVP United Nations Agencies Joint United Nations Programme on HIV / AIDS United Nations Population Fund United Nations Commissioner for Refugees United Nations Children's Fund U.S. Agency for International Development World Alliance for Breastfeeding Action United Nations World Food Programme World Health Assembly WHO 2010 Guidelines on HIV and infant feeding World Health Organization Zidovudine (same drug as AZT)

A U.K. study found a surprising five and a half times, or 550 %, the number of eventual IBD (irritable bowel disease) developments after antibiotic exposure before the age of one, versus no antibiotic exposure in childhood.

Studies examining the role of breast - feeding in the development of allergic disease in infants demonstrate potentially protective as well as neutral or nonprotective effects, likely due to the heterogeneity in their study design.

Studies examining the role of breast - feeding in the development of allergic disease in infants have failed to demonstrate the protective effect of breast milk because of the heterogeneity in study methods (including breast - feeding frequency, recall of feeding practices, and maternal atopic background).

«If the breast milk bacteria discovered in this study were important for the development of the immune system, its addition to infant formula could decrease the risk of allergies, asthma and autoimmune diseases,» conclude the authors.

Two weeks before the Systematic Review was published, the Lucas study — which aimed to test a hypothesis that «duration of breast feeding is related to changes in vascular function relevant to the development of cardiovascular disease» — was published in the BMJ alongside 2 press releases and a leader article.

Studies have shown that a protein in human milk aids in brain development, and breast - fed babies are less likely to get gastrointestinal infections and diarrhea, respiratory and ear infections or more serious diseases such as pneumonia, and there is a lower risk of Sudden Infant Death Syndrome.

One of the infectious agents the research team studied was the organism that causes tuberculosis (TB)-- a disease that is a huge problem in many countries of the world and getting worse because of the development of antibiotic - resistant strains.

Therefore within a few years we hope to be able to start studies in which we will also try treating patients to prevent the development of Alzheimer's disease,» says Hugo Lövheim.

«Population studies have consistently supported a protective role of nuts against cardiometabolic disorders such as cardiovascular disease and type 2 diabetes, and we know that inflammation is a key process in the development of these diseases,» said corresponding author Ying Bao, MD, ScD, an epidemiologist in BWH's Channing Division of Network Medicine.

«I think it awakens the possibility of gene therapy for neuropsychiatric diseases,» says Husseini Manji, a senior investigator at Johnson & Johnson Pharmaceutical Research & Development in Titusville, N.J., who was not involved in the study.

We wanted to find a way to assess brain damage that could predict the development of dementia associated with vascular diseases,» said Daniela Carnevale, Ph.D., the study's senior author and assistant professor at Sapienza University of Rome, based in Neuromed Institute.

«Chronic inflammation of the intestine is thought to be caused by abnormal interactions between gut microbes, intestinal epithelial cells and the immune system, but so far it has been impossible to determine how each of these factors contribute to the development of intestinal bowel disease,» said Hyun Jung Kim, Ph.D., former Wyss Technology Development Fellow and first author on the study, speaking about the limitations of conventional in vitro and animal models of bacterial overgrowth and inflammation of the development of intestinal bowel disease,» said Hyun Jung Kim, Ph.D., former Wyss Technology Development Fellow and first author on the study, speaking about the limitations of conventional in vitro and animal models of bacterial overgrowth and inflammation of the Development Fellow and first author on the study, speaking about the limitations of conventional in vitro and animal models of bacterial overgrowth and inflammation of the intestines.

In a groundbreaking study that provides scientists with a critical new understanding of stem cell development and its role in disease, UCLA researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first - of - its - kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the embryo.

To find the answers, further study on this difference will be needed to gain a better understanding of susceptibility to disease, efficacy of drugs and even the course of normal development among all individuals, not just between men and women.

And when development goes wrong, as it does with many diseases, we can study that outside the body.

Scientists have shifted from studying single molecules to investigating large complexes of interacting biological macromolecules involved in processes such as metabolic pathways, gene expression, and development of disease.

Further studies are needed to elucidate the role of both exogenous and endogenous viruses in the development of autoimmune disease, Dr. Crow said.

This study is the first, however, that examines structural analysis and its impact on disease development.

We believe that they will also lead to the development of a whole new range of therapies for neurodegenerative diseases of the central nervous system,» explains corresponding author of the study Jihwan Song, professor and director of Neural Regeneration and Therapy Group at the CHA Stem Cell Institute of CHA University.

The study shows showed that the PSC patients had lower coffee consumption both currently and in the early adulthood, suggesting that coffee consumption could protect against the development of the disease.

A new WIREs Systems Biology and Medicine review systematically brings this information together to identify the major milestones in the development of systems approaches to the modeling and study of Parkinson's disease and DBS.

They said the key messages from the study were that stroke is a highly preventable disease globally, regardless of age and sex; that the relative importance of modifiable risk factors means there should be development of regional or ethnic - specific primary prevention programs, and that additional research on stroke risk factors is needed for countries and ethnic groups not included in INTERSTROKE.

The study, the culmination of more than 10 years of research and published online in the journal Arthritis & Rheumatology in June, discovered virus - like elements within the human genome linked to the development of two autoimmune diseases: lupus and Sjogren's syndrome.

Studying these rare diseases «can open a new way to understand the imprinting phenomenon, to see how, in the beginning of the development of the embryo, the embryo answers to stimuli» that regulate how its genes behave, says Giovanni Battista Ferrero, a pediatrician at the University of Turin in Italy.

The journal provides cutting - edge research including results from animal models that are likely to apply to patients, studies in human tissue that provide new information about therapies or disease, and innovative reports of drug discovery and development.

«This approach, termed DiceCT, can be widely applied, not just for evolutionary studies but also as a powerful tool for biomedical investigations of brain development in disease, congenital defects, or injury,» she said.

Studies exploring how neurons mature are helping researchers to understand what goes wrong in diseases of brain development.

«It is expected that this study will lay the foundation for developing a new class of potent and effective cancer therapies and the development of reagents targeting epigenetic events in immune - mediated diseases as well as other epigenetically - influenced diseases,» said Alani, who also is chief of dermatology at Boston Medical Center.

«Our study enabled us to show for the first time that each of these three parameters — virus load, virus diversity and infection duration — influences the development of broadly neutralizing antibodies independently of each other,» explains Huldrych Günthard, professor of clinical infectious diseases at UZH.

This mechanism may be involved in many more diseases,» explains study's co-author, Dr. David Rosenblatt, a scientist in the Child Health and Human Development Program at the RI - MUHC and holder of the Dodd Q. Chu and Family Chair in Medical Genetics in the Department of Human Genetics at McGill University.

The study was sponsored by the U.S. Centers for Disease Control and Prevention, U.S. Food and Drug Administration, National Institutes of Health, President's Emergency Plan for AIDS Relief, U.S. Agency for International Development, Rockefeller Foundation, Medtronic, Merck Foundation, and BD (Becton, Dickinson and Company).

While Ruth has focused on providing the basis for the development of a malaria vaccine, Victor concentrated on basic immunology, studying the structure and function of various immune components and the parasitology of malaria and Chagas disease.

She continued: «Therefore, in further studies, we should investigate how and at what point DPP4 inhibitors can be used in diabetes therapy to prevent the development of non-alcoholic fatty liver disease.»

However, the role of this deletion in the development of the disease remained unclear going into this study.

Approximately 42 % of children in the study with MRI findings of MS developed the first clinical symptoms of the disease about two years after the abnormal MRI, which shows a faster development of the disease than has been reported in adults.

This is one of the diseases whose development researchers will now be able to study in the lab.

This study was designed to better define the process by which ALS progresses and to explore the role of brain motor neurons in disease development and progression.

«After our animal studies showed that GM - CSF was important in the development of an MS - like disease, we were excited to see these results confirmed using samples from MS patients in the current study,» says Abdolmohamad Rostami, M.D., Ph.D., Chair of the Department of Neurology at Thomas Jefferson University and director of its neuroimmunology laboratory.

Yonju Ha, a lead author of this article, said that further studies on this receptor and its role in white blood cell recruitment following tissue injury may aid in the development of new interventions for diseases associated with nerve injury, such as TON, stroke, diabetic retinopathy and glaucoma.