Sentences with phrase «studying disease pathways»

Not exact matches

In a new study published in the Journal of Allergy and Clinical Immunology, Paller, the Northwestern Medicine chair of dermatology, together with Dr. Emma Guttman - Yassky of Mount Sinai Medical School, discovered that an arm of the immune system — the Th17 pathway — in these patients is way too active, and the higher its activity, the worse the disease severity.

Clinically important findings suggest that targeting the epidermal growth factor receptor (EGFR) and the fibroblast growth factor receptor (FGFR) cellular pathways may benefit thousands of patients with this disease, according to the study published today in the journal PLOS Genetics.

By pinpointing one pathway of iCCA, this study opens up a new line of investigation to identify biomarkers of the disease.

Scientists have shifted from studying single molecules to investigating large complexes of interacting biological macromolecules involved in processes such as metabolic pathways, gene expression, and development of disease.

By studying these relationships, the researchers have discovered a new pathway to identify how genes influence disease, according to Boerwinkle.

«With this study, we have validated both NOX1 and NOX4 as core mediators of liver fibrosis and laid out the step - by - step cellular pathways that lead to this disease.»

«This research shows the intricate workings of a biological pathway crucial to the development of Huntington's disease, and is highly relevant to drug development,» said study leader Beverly L. Davidson, Ph.D., director of The Center for Cellular and Molecular Therapeutics at The Children's Hospital of Philadelphia (CHOP).

«We hope that the results from this study will enable investigators to test the relevance of the maresin pathway in human disease,» said Charles N. Serhan, Ph.D., a researcher involved in the work from the Brigham & Women's Hospital and Harvard Medical School in Boston, Mass. «Moreover, we hope to better understand resolution biology and its potential pharmacology so that we can enhance our ability to control unwanted inflammation and improve the quality of life.»

«Overall,» Dr. Schwartz added, «the study underscores the importance of rational drug design, in which drugs are designed to interact with specific molecular pathways involved in a particular disease.

Once they found that the OTULIN gene was abnormal in the sick children, they studied the immune pathway in order to understand the mechanisms of disease and to improve treatment of these patients.

A new study in American Journal of Physiology — Heart and Circulatory Physiology identifies the involvement of a protective response pathway, the heme oxygenase system, that has potential as a new therapeutic strategy for cardiovascular diseases.

«We've seen hints before that PAK4 and PI3K pathway are linked, but finding evidence of their interaction is an important advance because it gives us additional avenues to explore in testing promising new inhibitor compounds that can tackle this disease,» says Dr Claire Wells, who led the study.

«If we could manipulate this lipid pathway, we could go after Huntington's disease, because in our studies the drugs were really beneficial,» he said.

If we can therapeutically target that pathway, we may be able to have an impact on this very difficult - to - treat disease,» says the study's senior investigator, Derek Radisky, Ph.D., a researcher with the Mayo Clinic Cancer Center in Jacksonville, Fla..

«TWEAK and its signaling receptor, Fn14, have emerged as a fundamental molecular pathway regulating tissue responses after acute tissue injury and in many different contexts of chronic injury and disease» said Linda Burkly, Ph.D., Senior Distinguished Investigator, VP, Biogen, Inc., and co-senior author on the current study.

«Research in the last couple of decades has shown that microbes can exploit [cell death] pathways to cause disease,» says study coauthor Tobias Hohl, an infectious disease researcher at Memorial Sloan Kettering Cancer Center in New York City.

«PINK1 protein crucial for removing broken - down energy reactors: Study suggests potential new pathway to target for treating ALS, other diseases.»

«In our study, we identified novel potential pathways to finding treatments for this relentless disease.»

Case studies described in the article show how microRNAs may affect voluntary alcohol consumption in mice, candidate genes within signaling pathways associated with chronic obstructive pulmonary disease, and the microRNA: gene interactions that influence bladder cancer.

The recent studies suggest that dietary sodium intake may affect heart disease risk through pathways in addition to blood pressure.

Researchers are still working to understand just how some of these pathways and hormones can influence disease risk, primarily through animal studies in the lab.

«Flies are a simple, fast way of getting at the pathways that are involved in TBI,» says Leo Pallanck, who studies neurodegenerative diseases in fruit flies at the University of Washington.

Studies have shown that Alzheimer's disease hampers memory by first acting on the entorhinal cortex (EC), a brain region that provides the major input pathways to the hippocampus.

The current study focused on the genetic pathways that cause a rare genetic disease called Li - Fraumeni Syndrome or LFS, which comes with high risk for many cancers in affected families.

«This study reveals new pathways in the earliest stages of ALS - FTD and opens the way for developing new classes of drugs to combat this dreadful disease,» said Justin Fallon, a professor of neuroscience at Brown and researcher at the Brown Institute for Brain Science and one of the study authors.

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Some are at a basic research level, where investigators study genetic variation to identify pathways that can be targets for common diseases, such as diabetes and common birth defects.

The genes identified by this study may implicate pathways involved in inflammation, movement of proteins within cells, and lipid transport as being important in the disease process.

Katja Schurig (Storch, TUD)-- «Tissue engineering for reconstructing the central dopaminergic nigro - striatal pathway in Parkinson's disease: Cutting edge cell culture studies» (2012)

The use of NHP in biomedical research is justified in the studies of human diseases, to learn more about their causal pathways, their development, their infectiveness and to develop therapeutic and preventive strategies.

Our studies on convertase - mediated opioid peptide synthesis are relevant to the control of pain pathways, while our work on two secretory chaperones (first identified through their potent blockade of convertase aggregation) is of potential interest to patients with Alzheimer's and many other neurodegenerative diseases involving protein aggregation.

MyBioSource has worked hard to provide a variety of products, including monoclonal antibodies that are reactive with a wide variety of species and can be used to study various disease states and physiological pathways.

In recent years, researchers have developed so - called «senolytic» drugs that wipe out senescent cells in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 2019.

Although these studies were limited to small patient numbers, given the rarity of this disease, PD - 1 pathway blockade seems to have clinical efficacy in mucosal melanoma, with a tolerable safety profile.

More recently, his lab started studying the genetic basis of human brain evolution as well as the signaling pathways underlying synaptic loss during early stages of Alzheimer's Disease progression.

She is registred to the National Order of Biologists in the province of Palermo; collaboration in research project from 2012 to 2015 at the Department of Biopathology and Biotechnology, University of Palermo, focusing the study on the identification of molecules capable to modulate intracellular metabolic pathways for the prevention and treatment of infectious, tumor and degenerative disease, in collaboration with Prof. Angela Santoni, University of Rome; collaboration in research project in 2011 at the hospital «Villa Sofia Cervello» of Palermo to study methods can cure the genetic defect that causes thalassemia through genetic engineering; she studies different mechanisms of the differentiation and the activation of human gammadelta T cells as effector cells of the immune response against cancer and infectious diseases; she investigates about the identification and development of biomarkers of resistance and susceptibility to Mycobacterium tuberculosis infection; Valentina Orlando has published 13 papers in peer reviewed journals and 3 comunications at national and international congress.

«This study reveals new pathways in the earliest stages of ALS - FTD and opens the way for developing new classes of drugs to combat this dreadful disease,» says study author Justin Fallon, PhD, a professor of medical science and of psychiatry and human behavior, and a researcher at the Brown Institute for Brain Science.

A promising experimental compound prevents cholesterol gallstone disease in mice by stimulating the biochemical pathway that controls bile acid secretion by the liver, according to new studies by...

She joined the Polleux lab in 2014 and studies the role of the AMPK - ULK kinase pathway in Alzheimer's Disease.

Moreover, PHENONIM - ICS is involved in European projects presenting a strong impact on human health: Interreg CARDIOGENE (Genetic mechanisms of cardiovascular diseases), GENCODYS (Genetic and epigenetic networks involved in cognitive dysfunctions), AgedBrainSYSBIO (Basic studies of brain aging), as well as projects in partnership with industry: MAGenTA (an Industrial Strategic Innovation project supported by Bpifrance about the treatment of major urogenital diseases) and CanPathPro (H2020 program), to develop a predictive modeling platform of signaling pathways involved in cancers.

We are now using these models to study the gene function and complex mechanisms underlying disease pathways, with a focus on genetic background effects, genetic modifiers and interaction partners.

Well, we really don't know at this time, but based on some of the studies done, it appears that both can occur simultaneously, but depending on the mechanism leading to metabolic disease it can involve one or both pathways.

While studying a rare genetic disease, researchers discovered a signaling pathway linked to the efficiency of reprogramming somatic cells into stem cells.

By studying these processes, we hope to gain a better understanding of how cells respond to various stresses to ensure the normal development of tissues and uncover novel pathways that could be exploited to prevent disease progression.

Our studies will clarify the precise identity of neurons involved by pathology and undergoing cell death in AD, and point to the main molecular pathways that confer vulnerability or resistance to disease.

His research focuses on studying the role that SUMOylation (a protein modification pathway) plays in Huntington's disease, with hopes of targeting the SUMO pathway to identify novel therapeutic targets.

Potential projects include identifying common pathways that modify retinal degenerative disease from a large collection of actively maintained mouse models; determining molecular networks implicated in pathological disruption of the retinal pigment epithelium; identifying molecular pathways that regulate postnatal ocular growth; and using mouse models to assess the pathogenic role of gene variants that increase the risk of age - related macular degeneration as identified by human genome - wide association studies.

Many of the comorbidities of COPD, such as cardiovascular disease, bone disease and diabetes, may also share these ageing pathways and future studies should investigate this.

«This study provides strong evidence for a mechanism by which the stop pathway overcomes the go pathway in Parkinson's disease,» says first author Philip Parker, PhD, a former graduate student in Dr. Kreitzer's lab at the Gladstone Institutes and the University of California, San Francisco (UCSF).

Also of wide impact have been Goldberg's studies showing that the ubiquitin proteasome pathway is critical in the clearance of misfolded proteins and in muscle atrophy in many disease states, as well as in antigen presentation to the immune system.