Sentences with phrase «studying drug metabolism»
The simplified platform eliminates the need for pumping and tubing connections and provides a novel, easy - to - use platform for studying drug metabolism, toxicity and interactions between multi-tissue systems, serving as a robust, valuable tool for screening drugs for toxic effects.
https://www.sciencedaily.com/ Not exact matches
In the study, mice were given food until they became obese, and were then fed the drug, which increases the cellular metabolism of obesity - linked white fat cells.
«Cutting off cervical cancer's fuel supply stymies tumors: Drug combo shuts down tumor metabolism, mouse study shows.»
These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.
«WeizMass and MatchWeiz can serve as extremely powerful tools for studying plant metabolism and identifying metabolites with useful biological activity, including potential drugs,» says Aharoni.
To find out if tweaking current overdose protocols could prevent fatal liver damage, Duke mathematicians Lydia Bilinsky and Mike Reed and Duke biologist Fred Nijhout developed a mathematical model of acetaminophen metabolism, based on previous studies of lab rats given high doses of the drug.
Butler advises graduate students interested in industry to do two things: complete an internship at a company and make sure that they attend critical conferences related to drug metabolism and pharmacokinetics — such as the International Society for the Study of Xenobiotics.
Krainc and his colleagues showed this is due to differences in metabolism of dopamine between species, and underscored the importance of studying human neurons to discover new targets for drug development.
The drug, SRT1720, kept mice with high - calorie diets from becoming obese or diabetic, according to a study published in Cell Metabolism [subscription required].
By studying the regulation of the clock proteins called Period (PER) and Cryptochrome (CRY)-- proteins that are thought to be involved with metabolism — St. John and Doyle were able to model the mechanisms of two small - molecule drugs — Longdaysin and KL0001 — that regulate the expression of the clock proteins.
«Our results provide a large body of evidence demonstrating that the harmine drug class can make human beta cells proliferate at levels that may be relevant for diabetes treatment,» said senior study author Andrew Stewart, MD, Director of the Diabetes, Obesity and Metabolism Institute at the Icahn School of Medicine.
This protocol has been successfully applied to the high incorporation of deuterium and tritium in 18 drug molecules, which meet the requirements for use in ligand - binding assays and absorption, distribution, metabolism, and excretion studies.
A light - promoted atom transfer protocol uses heavy water to isotopically label alkyl sites for drug metabolism studies.
The hope is that by studying both males and females, scientists will gain better insights into sex differences ranging from behavior to brain anatomy to drug metabolism.
The Drug Metabolism study will assist researchers in the area of drug development and human biolDrug Metabolism study will assist researchers in the area of drug development and human bioldrug development and human biology.
The investigators are currently designing a study to correlate pharmacokinetics, the time course of drug metabolism, with genotype.
Study suggests a candidate drug had effects on a range of enzymes involved in the brain's metabolism
Gut bacteria that make up the gastrointestinal microbiome play an important role in the metabolism of most chemicals humans ingest, motivating studies of microbe - driven breakdown of clinically important drugs.
«Liver tissue model accurately replicates hepatocyte metabolism, response to toxins: Microfluidic device may help predict toxic effects of new drugs, study liver disease.»
«We found that at least seven bHLH - PAS proteins have pockets where drugs would fit and remain tightly bound,» said Fraydoon Rastinejad, Ph.D., professor in the Integrative Metabolism Program and senior author of the study.
«Alterations of metabolism in general are key to diabetes, and studies like this may have huge potential for unraveling new pathways which will lead to developing new drugs and new diagnostic tests,» she adds.
LA JOLLA — A team led by scientists at The Scripps Research Institute (TSRI) and the Salk Institute for Biological Studies has discovered two enzymes that appear to play a role in metabolism and inflammation — and might someday be targeted with drugs to treat type 2 diabetes and inflammatory disorders.
The Intestine Chip therefore may be useful as a research tool for applications where normal intestinal function is crucial, including studies of metabolism, nutrition, infection, and drug pharmacokinetics, as well as personalized medicine.
«Our studies of p75NTR's unanticipated role in regulating glucose metabolism suggest a new target for drug therapies,» said Dr. Akassoglou.
The position will provide a unique and multidisciplinary exposure to in vivo gut microbiome studies, lipid / lipoprotein metabolism, metabolomics, and drug development.
Studies determining Absorption, Distribution, Metabolism and Excretion (ADME) patterns in laboratory animals and humans are an integral part of the Drug Metabolism and Pharmacokinetics (DMPK) services provided by QPS.
The Hu laboratory studies endoplasmic reticulum (ER), which has critical functions in lipid synthesis, calcium storage and drug metabolism.
The researchers are currently studying which drugs, or combination of drugs, work best to promote localized browning and increase overall metabolism.
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Dr. Powers completed a clinical drug safety trial for the use of Advantage Multi for Cats (Bayer) in domestic ferrets, and has conducted several other research studies while at Carolina Veterinary Specialists, including an investigation into the metabolism of the anticonvulsant drug phenobarbital in African grey parrots and ongoing studies investigating a newly characterized intestinal parasite of cockatiels, Spironucleus meleagridis.
Proficient in HPLC, LC / MS, GC / MS, LC - NMR, Protein Purification and Characterization, Drug Metabolism Studies, NMR, GLP Requirements.