Sentences with phrase «studying drug resistance»

In 2015, grants funded a range of projects from testing new drug combinations to treat metastatic lung cancer to studying drug resistance in ovarian cancer.

At the National Human Genome Research Institute, she's studying drug resistance in melanoma and in the lab performs Western blots on the gene products of SOX10 and PTEN.

«I study drug resistance.

The researchers also plan to use this technology to study drug resistance and are developing additional platforms to guide decision making in the clinic.

Not exact matches

Through week 48, Biktarvy was found to be statistically non-inferior to ABC / DTG / 3TC with a numerically lower incidence of mild or moderate study drug - related adverse events and no treatment - emergent resistance;

Studies are showing that, not only do antibacterial soaps lack any benefits over using regular old soap and water, but that they could be harmful in that they potentially increase the risk of drug - resistance.

However, the patients treated virtually were more likely to be prescribed a broad - spectrum antibiotic — concerning since overuse of the drugs increases costs and contributes to antibiotic resistance, according to the study.

«A major challenge in tackling the problem of antibiotic resistance is to discover new drugs — our study shows that potentially useful drug candidates can be «discovered» from amongst the antibiotics we already know about.»

A new study by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibitors.

Tissue engineering provides a more practical means for researchers to study cell behavior, such as cancer cell resistance to therapy, and test new drugs or combinations of drugs to treat many diseases.

Published in the journal Molecular Cancer Therapeutics, the study also found that use of a second inhibitor might improve the effectiveness of these drugs by possibly preventing resistance, and it recommends that clinical trials should be designed to include a second inhibitor.

This study suggests that a combination of rapamycin and another drug to offset that increase in insulin resistance might provide the benefits of this medication without the unwanted side effect.

In two studies, Freiburg researchers have made new discoveries concerning the relationship between CML and Gab2 and drugs that can break a particular resistance to Gab2 in CML cells.

«Recent studies suggest that epigenetic modifications may contribute to the development of cancer progenitor cells that can induce drug resistance and the relapse of different types of cancer,» said Sibaji Sarkar, PhD, instructor of medicine at BUSM.

A recent study from a U.K. commission on antimicrobial resistance estimated that by 2050, antibiotic - resistant bacterial infections will kill 10 million people per year, if no new drugs are developed.

The study found several genes that are associated with resistance to antibiotics, including new genes that might point to previously unknown mechanisms of drug resistance.

Both groups confirmed in genetic, cell, and clinical studies that, for the first time, the parasite had developed resistance to both drugs used in an ACT.

On the scientific agenda are identifying molecular markers for resistance, which would simplify testing; accelerating the development of alternative drugs; and studying the effectiveness of mass screening and treatment to eliminate malaria in the areas where resistance occurs.

In addition, the investigators found, among the HPTN 052 participants who failed treatment, those who had a higher viral load when they joined the study were more likely to develop resistance to their antiretroviral drugs.

Seasonal flu strains such as H1N1 and H3N2 have shown little resistance to the drug in adults, but two small studies have shown resistance rates of up to 18 % in Japanese children (ScienceNOW, 26 August 2004).

«One criticism of the PARP drugs is they are not active in patients who have developed resistance to other therapies, but we found veliparib appears to be effective in some platinum - resistant patients with recurrent or persistent disease,» said Robert L. Coleman, MD, lead author of the study and professor and vice chair of clinical research at the University of Texas MD Anderson Cancer Center, Houston.

In addition, the investigators found that among the HPTN 052 participants who started antiretroviral therapy early but failed treatment before May 2011, those who had a higher viral load when they joined the study were likely to develop resistance to their antiretroviral drugs.

The study published Oct. 17 in Cell Reports has implications for our understanding of the evolution of resistance to antimicrobial and anticancer drugs.

«Our study suggests that the lack of sufficient IGF - 1 activity may underlie lithium resistance in the treatment of bipolar disorder, and this hormone, or drugs mimicking or promoting its action, should be considered for improved treatment of this disorder,» says Dr. Milanesi.

The study results also suggest that the drug combination can delay or overcome resistance to fulvestrant.

In animal and cell culture studies, the drug inhibited growth both in estrogen - dependent breast cancer cells and in cells that had developed resistance to the anti-estrogen tamoxifen and / or to the aromatase inhibitors, two of the most widely used types of drugs to prevent and treat estrogen - dependent breast cancer.

Reducing inflammation with a drug such as celecoxib «reverses treatment resistance and enhances overall antidepressant response,» Dr. Halaris wrote in the study.

They found evidence that the drug turns on the gene that produces the protein «FOXO,» a master regulator of stress resistance in many organisms that is often central in longevity studies.

«Until now, no studies have separated how resistance to these two different drug actions might work,» says Roepe, also a professor of biochemistry and cell and molecular biology and co-founder of Georgetown's Center for Infectious Disease at Georgetown University Medical Center.

The professor and his colleagues demonstrated in their study that while resistance to drugs like chloroquine, which works to slow the growth of malaria, has been explored, an explanation of the resistance to the cell - destroying effects of the medication has not been fully understood.

Published in Nanomedicine, the study identified a new mechanism of targeting multi-subunit complexes that are critical to the function of viruses, bacteria or cancer, thus reducing or possibly even eliminating their resistance to targeted drugs.

«How cytoplasm «feels» to a cell's components: In study that may guide drug design, researchers find organelles encounter varying levels of resistance.»

«Study first to explain type of antimalarial drug resistance.»

A new study led by University of Kentucky researchers suggests a new approach to develop highly - potent drugs which could overcome current shortcomings of low drug efficacy and multi-drug resistance in the treatment of cancer as well as viral and bacterial infections.

The other study — Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma — published March 30, shows how drugs targeting PI3K and MAPK could represent promising candidates for glioblastoma therapy.

As a clinician - scientist with a translational research focus, Dr. Deininger is heading an extramurally funded research laboratory that is dedicated to the study of signaling pathways, drug resistance, and new molecular therapies in leukemia.

Growing resistance to malaria drugs in Southeast Asia is caused by a single mutated gene inside the disease - causing Plasmodium falciparum parasite, according to a study led by David Fidock, PhD, professor of microbiology & immunology and of medical sciences (in medicine) at Columbia University Medical Center.

A study published on June 25th in PLOS Pathogens reports a new way to circumvent drug resistance and lower the curative dose by delivering existing drugs directly into the parasite, a high - tech approach with potential applications to other infectious diseases.

«We know that amlexanox works to reverse obesity and insulin resistance in part by resolving chronic inflammation and increasing energy expenditure, but that's not the whole story of the drug's effects,» said Shannon Reilly, first author of the study.

«Now, because we know the resistance mechanism, we can design elements to minimize the emergence of resistance as these promising new drug candidates are developed,» said Ben Shen, a TSRI professor who led the study, which was published February 20, 2014 online ahead of print by the Cell Press journal Chemistry & Biology.

He published another study in August 2015, showing that resistance to the chemotherapy drug doxorubicin is likewise increased by ALAN.

The implication of this proof - of - concept study of a novel technology for reversing transporter - related drug resistance, they say, «is not limited to a single nanobody used to demonstrate the technology, nor to a single drug, nor indeed to trypanosomiasis.»

The letter states that the pause potentially applies to six projects that range from studying the ecology of avian flu in live bird markets in Colombia to looking at drug - resistance mutations in seasonal influenza strains.

«Although the approaches employed in our study are not novel in themselves, the scale of the analyses is unprecedented and allowed us to track in public databases the dynamics of all known mutations involved in drug resistance,» reported the senior author.

People who exhibit a resistance to aspirin may be more likely to have more severe strokes than people who still respond to the drug, according to a study released today that will be presented at the American Academy of Neurology's 67th Annual Meeting in Washington, DC, April 18 to 25, 2015.

Drugs that target this machinery would not kill the microbes, just stop them from hanging on, so they should be less likely to provoke resistance, says David Brown of charity Antibiotic Research UK, who was not involved in the study.

Heterogeneity in a bacterial population that arises through a mechanism of biased partitioning of drug efflux pumps, as we identified in our study, could be a stepping - stone on the path of bacterial populations towards antibiotic resistance.»

«This offers a new way to study the molecular mechanisms associated with drug response and drug resistance,» said Shen.

In an ambitious study, the authors attempt to trace drug resistance against all strains of the flu by using an extensive influenza virus database containing all known genetic sequence information (70,000 complete nucleotide sequences) for influenza strains.

HeLa cell lines, derived from the cervical cancer of a woman named Henrietta Lacks, have been used for decades to study resistance to cancer drugs.