Sentences with phrase «studying embryonic development»
Birds have been the model organisms for studying embryonic development for many years, but the difficulty in applying transgenesis to birds has hampered the use of the avian model in modern science.
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Clues to Urbilateria's brain plan come from studying the embryonic development of creatures alive today.
Experts say the new method, reported in the current issue of Cell, could also be a useful tool for studying embryonic development.
In the meantime, Boeke says Sleeping Beauty could provide a new and better way to create mutants to study embryonic development, since the inactivated gene can be «tagged» using a short DNA sequence inserted by the transposon.
Not exact matches
«That was what was different in this particular study, we created a differentiation protocol to mimic embryonic development.»
Some of the researchers at the centre will study the differentiation of stem cells into other cell types, one group by using human embryonic stem cell biology and another by studying early embryo development.
For this study, Guttridge, first author David J. Wang, who developed many of the study's concepts, and their colleagues monitored NF - kB activity during tumor development using mouse embryonic fibroblasts and two mouse models.
«Furthermore, results of our study highlight the importance of including moisture conditions when predicting embryo growth and sex ratios and in developing proxies of embryonic development.
A new study indicates an essential role for a maternally inherited gene in embryonic development.
For years, Scripps neuroscientist Jerold Chun had been studying the embryonic brain and how certain lipids in the blood of both the mother and the embryo affect its development.
Study shows memories formed by the same gene - silencing tool used in embryonic development; a finding could set the stage for new therapies for schizophrenia
Mainstream biology has followed in Morgan's wake, focusing on animals suitable for studying genetic and embryonic development.
«Indeed, when we studied the mice at the embryonic stage, we saw the cells between the muscle fibers expanded explosively and formed tumors early in development,» Hatley said.
Mouse embryonic stem cells, reported in 1981 by Martin Evans, Matthew Kaufman, and Gail Martin, have allowed scientists to generate genetically customized strains of mice that have revolutionized studies of organismic development and immunity and have provided countless models of human disease.
The study highlights the tenuous steps in embryonic development related to sex determination and how a single genetic mutation can mean the difference between male and female.
They hope to study APOBEC's importance in fighting off mutations early in the development of embryonic life, and in the development of the eggs and sperm that carry our genes to the next generation.
«We studied how the Sox2 gene is turned on in mice, and found the region of the genome that is needed to turn the gene on in embryonic stem cells,» said Professor Jennifer Mitchell of U of T's Department of Cell and Systems Biology, lead invesigator of a study published in the December 15 issue of Genes & Development.
«For several years, we have been studying myogenesis, a process by which muscles are formed during embryonic development,» says Jean - François Côté, PhD, Director of the Cytoskeletal Organization and Cell Migration research unit at the IRCM.
This discovery by the scientists at the CRG provides an insight into stem cell - forming molecular mechanisms, and is therefore of great interest for studies on the early stages of life, during embryonic development.
Embryonic development is a well - studied process in which the precise regulation of gene expression is critical, since many genes are expressed simultaneously and in a punctual manner.
This is a relatively new paradigm in the study of evolution, which focuses on comparing the embryonic development of multiple living beings to understand how their adult forms have changed giving rise to new species.
«Studies on embryonic development greatly benefit from the culture system of embryonic stem cells and, more recently, induced pluripotent stem cells.
To fill that gap, the researchers used mice to study the genetics behind embryonic development of the stomach.
Veronica Palma, from University of Chile, led the study with Rehen and highlights the combined approaches allowed the creation of an environment that mimics the one during embryonic brain development.
The gene's apparently crucial role in embryonic development «is remarkable,» says William Kimberling, a geneticist at Creighton Medical School in Omaha, Nebraska, who studies children with BOR.
Because the RNAi wasn't used to dampen FOXP2 activity until 23 days after the birds hatched, the new study shows that the gene has a role beyond embryonic development, says neurogeneticist Simon Fisher of the University of Oxford in the U.K. «The gene, at least in songbirds, may have important active functions in [neural] circuits,» he says.
To achieve this result, the researchers studied the interactions between some molecules that control embryonic development.
The researchers hope that these assays will be used by many laboratories that are studying the events associated with early embryonic development and the effect of repeat length and methylation status on gene expression and differentiation.
Other potential uses of embryonic stem cells include investigation of early human development, study of genetic disease and as in vitro systems for toxicology testing.
The researchers used this live - imaging technique to study fly embryos at a key stage in their development, approximately two hours after the onset of embryonic life where the genes undergo fast and furious transcription for about one hour.
«New methods such the CRISPR - Cas9 system for gene editing now make it possible to carry out functional studies in other species, and this will in turn lead to decisive advances in our understanding of early embryonic development in mammals.»
Caspary's lab studies the Hedgehog pathway in early embryonic development.
Zebrafish also express this gene, and the study showed that it plays a crucial role in embryonic development.
Fishman, in particular, wanted to advance his studies in oncodevelopmental biology, exploiting proteins involved in embryonic development as tumor markers.
«Discovery of a gene that could convert human embryonic stem cells into myocardial cells would be golden,» said Didier Stainier, PhD, UCSF assistant professor of biochemistry and biophysics, the senior author of the UCSF study and a pioneer in the study of heart development in the transparent zebrafish embryo.
Recently, his lab used induced pluripotent stem (iPS) cells — adult cells made to act like embryonic stem cells — made from skin cells of patients carrying apoE4, or other mutations related to Alzheimer's, to study their effects on the development, survival, and degeneration of human neurons.
Correspondingly, endothelial - specific deletion of Tie2 using Ve - cad - Cre driver mice, pursued in validating the Tie2fl / fl mice used in this study, essentially phenocopied the global Tie2 KO phenotype with embryonic lethality around E10.5 (Supplementary Fig. 13), confirming the key role of endothelial Tie2 during embryonic development.
Dr Ludovic Vallier, co-author on the study from the Wellcome Trust Sanger Institute and the Wellcome - MRC Cambridge Stem Cell Institute, said: «This study represents an important step in understanding human embryonic development.
Although additional research is required to propel the embryo into the next stage - that of a live fetus - this study offers a more comprehensive understanding of early embryonic development and could help improve fertility treatments.
Mouse brain tissue from three different stages of the mouse brain development; embryonic day 15, postnatal day 2 and postnatal day 21, was studied.
A variety of biological processes are being studied, mainly concerning embryonic development and development and homeostasis of organs.
Embryonic stem cells, Adult stem cells, Reprogramming to pluripotency and lineage conversion, Directed differentiation, Germ cells, Genetic and epigenetic mechanisms, Stem cells in development, Stem cell niche, Cancer stem cells, Disease modeling and drug screening, Stem cell therapy, Clinical studies in regenerative medicine, Tissue engineering and biomaterials, Imaging and diagnostics, Stem cell products, manufacturing, and quality control, Ethical, legal, and social issues Read Journal
In this study, the team delved deep into the nucleus of cells belonging to mouse and zebrafish embryos — two important animal models of embryonic development — in order to determine how the Dll4 gene is turned on.
10/10/2007 Researchers Reveal Repressor Protein Blocks Neural Stem Cell Development A protein known to repress gene transcription at the molecular level in a variety of processes also blocks embryonic neural stem cells from differentiating into neurons, according to a study by University of California, San Diego and Howard Hughes Me... More...
Embryonic stem (ES) cells are pluripotent and can be used to study germ cell development [1]--[5].
It is based on the definitive books of mouse embryonic development by Theiler (1989) and Kaufman (1992) yet extends these studies by creating a series of three dimensional computer models of mouse embryos at successive stages of development with defined anatomical domains linked by a stage - by - stage ontology of anatomical names.
These findings on gene expression in single embryonic stem cells are in concert with recent studies of early mammalian development, which reveal molecular heterogeneity and a stochasticity of gene expression in blastomeres.
It'll be tough for us not to continue down this road, in spite of some serious ethical questions, when most of what we know about human embryonic development comes from studying frogs, fish, chickens and mice.
Now researchers at the Salk Institute for Biological Studies have identified an essential cellular pathway in zebrafish that paves the way for limb regeneration by unlocking gene expression patterns last seen during embryonic development.
Since the signalling mechanisms affected in these diseases are the same mechanisms that occur during embryonic heart development, their study is a subject of great interest and relevance.