We have been
studying endocytosis in a broader, systems perspective, by combining quantitative imaging, genome - wide RNAi screens with systems biology analysis.
She still runs an eight - person lab,
studying endocytosis with four grad students who probably don't have to attend as many lab meetings as they used to.
Not exact matches
Among all the genes that control
endocytosis, the authors of the
study focused specifically on one, called RAB7; this gene is highly expressed in melanoma cells.
Dr. Taraska's lab
studies the structural cell biology of exocytosis and
endocytosis with advanced imaging methods including live cell microscopy, superresolution fluorescence, and electron microscopy.
The new method will allow cell biologists to accurately
study the timing of
endocytosis and what proteins are required.
Cell biologists have
studied for decades how
endocytosis works however up till now they have found it impossible to control the process.
This
study reports for the first time the occurrence of collective dynamics of
endocytosis and shows how this regulates the onset of cortical actin waves.
In particular, this
study demonstrates the capability to track structural dynamics and remodeling of the cell surface, such as morphogenesis of filopodia, membrane ruffles, pit formation or
endocytosis, in response to environmental stimulants.
Our
studies on the molecular mechanisms of
endocytosis led to the discovery that the small GTPase Rab5 is a master regulator of early endosome biogenesis.
While the
study shows that reduced SMN disrupts
endocytosis, it doesn't explain why.
Scaling great walls When they both started at Penn, Lee had a project on the effects of nerve growth factor on PC12 cells, and Trojanowski was
studying axonal transport and
endocytosis.
In one project, we
study the complex and dynamic protein machinery that performs clathrin - mediated
endocytosis in yeast.
In the Endocytic Trafficking and Intracellular Delivery team we
study the cell biology of carbohydrate - binding proteins (lectins) at the level of cellular entry though clathrin - independent
endocytosis, retrograde sorting on early endosomes, and translocation to the cytosol.
We
study the cell biology of carbohydrate - binding proteins (lectins) at the level of cellular entry though
endocytosis, retrograde sorting, and translocation to the cytosol.