The disruption of prenatal cellular activity in zebra fish, which share 80 percent of their genes with humans and are considered a good model for
studying human brain development, seemed to result in hyperactivity, according to the Canadian study, which was published Monday in the Proceedings of the National Academy of Sciences.
Not exact matches
Neuroscientists have over the past decade uncovered evidence, both in rodent and
human studies, that parental caregiving, especially in moments of stress, affects children's
development not only on the level of hormones and
brain chemicals, but even more deeply, on the level of gene expression.
While not a lot of research can tell us the effects of BPA on
humans,
studies on animals suggest it may be dangerous to
brain development, the reproductive system, and the immune system.
In 2007, researchers published the first randomized, controlled
study of the effect of being raised in an orphanage; that
study, and subsequent research on the same sample of Romanian orphans, found that compared with babies placed with a foster family, those who were sent to institutions had lower IQs, slower physical growth, problems with
human attachment and differences in functioning in
brain areas related to emotional
development.
Dr. Nina Kraus, a groundbreaking neuroscientist at Northwestern University, has been
studying the effects of music training on
brain development — with the use of non-invasive approaches in
humans — and on the
development of language skills.
Studies have shown that a protein in
human milk aids in
brain development, and breast - fed babies are less likely to get gastrointestinal infections and diarrhea, respiratory and ear infections or more serious diseases such as pneumonia, and there is a lower risk of Sudden Infant Death Syndrome.
She worked on multiple research
studies as a post graduate at the University of Washington's Institute of
Brain and Learning Sciences and Center on
Human Development and Disability.
«The
human organoids are good for
studying the very early stages of
brain development, but may not reveal much about later, more mature stages on which things like sociality depend,» says John Mason at the University of Edinburgh, UK.
Professor Jianfeng Feng commented that new technology has made it possible to conduct this trail - blazing
study: «
human intelligence is a widely and hotly debated topic and only recently have advanced
brain imaging techniques, such as those used in our current
study, given us the opportunity to gain sufficient insights to resolve this and inform
developments in artificial intelligence, as well as help establish the basis for understanding and diagnosis of debilitating
human mental disorders such as schizophrenia and depression.»
In the new
study, researchers mined databases of genomic data from
humans and chimpanzees, to find enhancers expressed primarily in the
brain tissue and early in
development.
«The cortex is a very important region in the adult
human brain that undergoes a complex, multi-stage
development process,» said Daniel Nagode, a former postdoctoral researcher at UMD and lead author of the
study.
The House bill orders the government to report on «the
development of safe nanotechnology,» including a
study of its use for self - reproducing machines, artificial intelligence, and «
human brain extenders.»
A
study conducted at the Max Planck Institute for
Human Development has investigated the relationship between the availability of nature near city dwellers» homes and their
brain health.
The
study was supported by the Eunice Kennedy Shriver National Institute of Child Health and
Human Development (K23 HD054720), Flora Family Foundation, UCSF Catalyst Award, UCSF Resource Allocation Program,
Brain & Behavior Research Foundation Young Investigator Award, Stanford University Lucile Packard Foundation for Children's Health, Spectrum Child Health & Clinical and Translational Science Award and the Extraordinary
Brain Series of the Dyslexia Foundation.
Finally, says Evrony, the findings provide a proof - of - principle for a systematic way of
studying how
brain cells disperse and migrate during
development, «something that has not been possible to do before in
humans,» he says.
The new research focused on just nine genes, those most strongly associated with autism in recent sequencing
studies, and investigated their effects using precise maps of gene expression during
human brain development.
Mark Blumberg, a psychology professor at the UI and senior author of the
study, says this latest discovery is further evidence that sleep twitches — whether in dogs, cats or
humans — are connected to
brain development, not dreams.
«This
study focused on the
development of the neocortex, but we aim to analyze multiple
brain regions and developmental stages to achieve a more comprehensive atlas of cell types in the developing
human brain,» Kriegstein said.
«For example, there is a huge amount of interest and excitement globally in growing cerebral organoids» — miniature
brain - like organs that can be
studied in laboratory experiments — «from stem cells to model
human brain development and disease mechanisms.
The approach enabled a wide range of
studies of
human brain development, including implicating a new class of neural stem cell recently discovered by the lab in the evolutionary expansion of the
human brain and identifying how the mosquito - borne Zika virus may contribute to microcephaly in infants infected in utero.
In the new
study, the researchers discovered that during the second trimester of
human brain development, oRG cells express genes related to a fundamental signaling pathway called mTOR, defects in which have previously been implicated in autism and several other psychiatric disorders.
The 3D tissue structures will let researchers
study the early stages of
human brain development in unprecedented detail.
«It's critically important to be able to look at questions of
brain development in real
human tissue when you're trying to
study human disease.
The use of neuroimaging was part of an effort to find noninvasive ways of
studying pig
brain development that could also be applied in
humans.
A second major theme is the
development of methods for
studying human brain structure and function using MRI and for integrating fMRI data with other imaging methods such as EEG.
Although the original impetus of the work was to
study human brain disease and
development, says Howard Hughes Medical Institute (HHMI) Investigator Christopher Walsh, the results also shed light on how the
human brain expanded during the course of evolution.
The work takes a step toward using
brain organoids to
study complexities of
human brain development and disease that can't be investigated with current techniques.
Therefore, hand - in - hand with the
development of selective ligands to inhibit BuChE in
brain, it is fundamental to optimize assay conditions for... kinetic
studies of
human BuChE.
One new way that scientists
study this process of cellular
development — and a way in which they hope to grow replacement tissue for medical treatments in the future — is by recreating the essential features of
human brains, eyes, lungs, and guts in a petri dish.
GIND investigator Li Gan, PhD, and her collaborators
studied the
development of neurons born in the hippocampus of adult mice genetically engineered to produce high levels of
human Aβ in the
brain.
Dr. Raichle's research led to the
development and use of positron emission tomography and functional magnetic resonance imaging, tools that have enabled scientists to safely and non-invasively
study the living
human brain and track and record its function in health and disease.
In the lab for
Human Brain and Neural Stem Cell Studies we aim at developing experimental paradigms to systematically identify novel types of neural stem and progenitor cells that serve as building blocks for brain develop
Brain and Neural Stem Cell
Studies we aim at developing experimental paradigms to systematically identify novel types of neural stem and progenitor cells that serve as building blocks for
brain develop
brain development.
While researchers have been able to
study how DISC1 mutations alter the
brain during
development in animal models, it has been difficult to find the right tools to
study changes in
humans.
Relatively few neuroimaging
studies have explored the role of puberty in
human brain development (Blakemore et al., 2010; Crone and Dahl, 2012; Galvan et al., 2012), though it was noted long ago that measurements of peak gray matter volume coincide with the onset of puberty (Giedd et al., 1999; Blakemore, 2012).
His research team is interested in identifying genes that direct the
development of the cerebral cortex, both because of their importance in
human diseases and because
studying those genes will help in learning about the normal
development and evolution of the
brain.
Three recent experimental
studies focused on low consumption / exposure.949596 In one
study, 29 smokers each consumed a single cigarette, immediately after which they had a significant decrease in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another
study,
human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the
development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A
study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on
brain cells.96
What we are learning is that the in utero environment may also affect the timing of future pubertal
development in offspring, which makes sense since
human brains are developed in utero and the
brain releases hormones affecting puberty,» said
study lead author Ai Kubo.
«Although we knew that the EAAT2 gene has a crucial role to play in neurological processes in
human and potentially in the
development of migraine, until now, no genetic link has been identified to suggest that glutamate accumulation in the
brain could play a role in common migraine,» says co-senior author of the
study Professor Christian Kubisch of University of Ulm, Germany (previously at the University of Cologne where he conducted his research for this
study.)
The delicate balance between the
human microbiome and the
development of psychopathologies is particularly interesting given the ease with which the microbiome can be altered by external factors, such as diet, 23 exposure to antimicrobials24, 25 or disrupted sleep patterns.26 For example, a link between antibiotic exposure and altered
brain function is well evidenced by the psychiatric side - effects of antibiotics, which range from anxiety and panic to major depression, psychosis and delirium.1 A recent large population
study reported that treatment with a single antibiotic course was associated with an increased risk for depression and anxiety, rising with multiple exposures.27 Bercik et al. 28 showed that oral administration of non-absorbable antimicrobials transiently altered the composition of the gut microbiota in adult mice and increased exploratory behaviour and hippocampal expression of
brain - derived neurotrophic factor (BDNF), while intraperitoneal administration had no effect on behaviour.
S. Lynneth Solis Mind,
Brain, and Education Program Current city: Cambridge Current job: Doctoral Student,
Human Development and Education, Harvard Graduate School of Education Career highlight: Collaborating with researchers at the Universidad de los Andes in Bogotá, Colombia to
study object play experiences of children in socioeconomically diverse preschools in the city
Silvia Rodriguez Vega, Arts In Education Ryan Shephard, Education Policy and Management Ann Piatt, Higher Education Maleka Gramling,
Human Development and Psychology Nathalie Galindo, International Education Policy Ashley Young, Language and Literacy Richard Beyer, Learning and Teaching Samuel Ronfard, Mind,
Brain, and Education Dorice Moise, Prevention Science and Practice Lewis Spears, School Leadership Dalia Said, Special
Studies Matthew Goetz, Teacher Education Devon Dickau, Technology, Innovation, and Education
Arts in Education: Aysha Upchurch Education Policy and Management: Jessica Lander
Human Development and Psychology: Olamide Abiose Higher Education: Rachel Freeman International Education Policy: Nicole Paulet Piedra Language and Literacy: Heather Elgin Learning and Teaching: Ahoba Arthur Mind,
Brain, and Education: Jayne Everson Prevention Science and Practice: Heather McCormack School Leadership: Cornelius Lee Special
Studies: Maya Ayoub Teacher Education: Elyse Terry Technology, Innovation, and Education: Nick Giacobbe
Arts in Education: John Sessler Education Policy and Management: Manny Lamarre
Human Development and Psychology: LaJoi Royston Higher Education: Jasmine Omorogbe International Education Policy: Matthew Williams Language and Literacy: Jin Hee Chung Learning and Teaching: Jonathan Yuan Mind,
Brain, and Education: Drew Nelson Prevention Science and Practice: Habib Bangura School Leadership: Tracie Sanlin Special
Studies: Margaret Okada Teacher Education: Jonathan Judson Technology, Innovation, and Education: Graham North
Intellectual Contribution / Faculty Tribute Award: Arts in Education: Shawn Lavoie Education Policy and Management: James Kelly
Human Development and Psychology: Tim Goodman Higher Education: Daniel Follmer International Education Policy: Kevin Kalra Language and Literacy: Maura Ross Learning and Teaching: Sedia Dennis Mind,
Brain, and Education: Bryan Mascio Prevention Science and Practice: Harry Schnur School Leadership: Lybroan James Special
Studies: Ryan Romaneski Teacher Education: Aaron Randolph Technology, Innovation, and Education: Harvey Shaw
She worked on multiple research
studies as a post graduate at the University of Washington's Institute of
Brain and Learning Sciences and Center on
Human Development and Disability.