Methodology challenges in
studying human gut microbiota — effects of collection, storage, DNA extraction and next generation sequencing technologies — Marina Panek — Scientific Reports
Not exact matches
Dr Luis Pedro Coelho, commented: «These findings suggest that dogs could be a better model for nutrition
studies than pigs or mice and we could potentially use data from dogs to
study the impact of diet on
gut microbiota in
humans, and
humans could be a good model to
study the nutrition of dogs.
Regulatory issues must be addressed before moving to
human studies, Davies said, but the findings published in the August issue of the Journal of Clinical Investigation suggest that it may be possible to manipulate the bacterial residents of the
gut — the
gut microbiota — to treat obesity and other chronic diseases.
The goal of the
study was to explore whether fecal
microbiota from
human IBS patients with diarrhea has the ability to influence
gut and brain function in recipient mice.
A deep global analysis of the
gut microbiota composition was done by phylogenetic microarray analysis using a
Human Intestinal Tract Chip (HITChip), an analytical device designed specifically for
studying gut bacteria.
Of special note today:
gut microbiota species expressing orthologs of
human Ro60 might be involved in triggering and sustaining chronic autoimmunity in lupus; The portal vein blood microbiome in patients with liver cirrhosis; A randomized clinical
study suggests dietary promotion of short chain fatty acid producing
gut microbes as an effective treatment for type 2 diabetes; and the sexual dimorphism of root, flower and leaf microbiomes in the wild strawberry plant
In a
study published as a letter to the journal
Gut, the team outline new evidence suggesting that the human genome may play a role in determining the makeup of the billions of microbes in the human gastrointestinal tract collectively known as the gut microbio
Gut, the team outline new evidence suggesting that the
human genome may play a role in determining the makeup of the billions of microbes in the
human gastrointestinal tract collectively known as the
gut microbio
gut microbiota.
Techniques Functional imaging of the interaction between
gut microbiota and the
human host: A proof - of - concept clinical
study evaluating novel use for 18F - FDG PET - CT.
The delicate balance between the
human microbiome and the development of psychopathologies is particularly interesting given the ease with which the microbiome can be altered by external factors, such as diet, 23 exposure to antimicrobials24, 25 or disrupted sleep patterns.26 For example, a link between antibiotic exposure and altered brain function is well evidenced by the psychiatric side - effects of antibiotics, which range from anxiety and panic to major depression, psychosis and delirium.1 A recent large population
study reported that treatment with a single antibiotic course was associated with an increased risk for depression and anxiety, rising with multiple exposures.27 Bercik et al. 28 showed that oral administration of non-absorbable antimicrobials transiently altered the composition of the
gut microbiota in adult mice and increased exploratory behaviour and hippocampal expression of brain - derived neurotrophic factor (BDNF), while intraperitoneal administration had no effect on behaviour.
Studies have also linked the
gut microbiota to
human mood and behavior, weight gain and loss as well as
gut health,
human development, and metabolic disorders.
The closest I've found to a
human clinical trial of beans on intestinal permeability is this
study, which found a Chinese medicinal gruel of Job's tears, oat, buckwheat, white bean, yellow corn, red bean, soybean, yam, big jujube, peanut, lotus seed, and wolfberry changed
gut microbiota, improved
gut permeability, lowered endotoxemia, and improved inflammation markers.