Sentences with phrase «studying luminal»

This model should be a powerful tool for testing therapies for aggressive ER + breast cancers and for studying luminal cancers — the most prevalent and deadliest forms of breast cancer.

Not exact matches

In this study published in Cell Reports, Alexandra Van Keymeulen and colleagues generated a new transgenic line - allowing lineage tracing of ER + luminal cells to investigate luminal cell heterogeneity and identify the origin of ER + luminal cells and the mechanisms regulating their pubertal expansion and adult maintenance.

The results suggest a clinical study should be conducted of a STAT3 - inhibiting drug in patients with basal - like and luminal cancers, Horvath said.

Their studies revealed that a subset of normal breast precursor cells, called luminal progenitors, have dangerously short telomeres and display a correspondingly high level DNA damage response localized at their chromosome ends.

Recent studies have implicated luminal progenitor cells in the development of breast cancers with a mutated BRCA1 gene.

Humans have an ortholog of the murine Nrk gene, and considering that the gene expression pattern in breast tumor in Nrk mutant mice was similar to that in human luminal B breast cancer, the findings of this study may lead to further understanding of the mechanisms of human breast cancer suppression and to advances in its diagnosis and therapy.

The Cancer Genome Atlas study encompasses more than 500 primary tumors representing the four intrinsic subtypes of breast cancer: Luminal A, Luminal B, Her2 - enriched, and Basal - like.

Luminal A tumors are the most prevalent (44 % in this study), followed by luminal B Luminal A tumors are the most prevalent (44 % in this study), followed by luminal B luminal B (24 %).

These 2D cultures also abolish the need for intraluminal microinjection of single organoids and facilitate studies of host - microbe or virus interactions or the action of microbial enterotoxins because the luminal surface is fully exposed to the mucosal medium (22,23).

Both reviewers consider that since the functional studies were only tested in 2 basal and 2 luminal breast cancer cell lines, the sample set was too small, and testing additional cell lines for their dependency on MELK should further strengthen the authors conclusions.