The center, founded in 2001, provides novel techniques for
studying mouse models of diabetes and other metabolic disorders.
Not exact matches
The researchers used two different
mouse models of diabetes to
study the effects
of the diet.
The new
study, using an experimental
mouse model of diabetes, is published online in the journal PLOS One.
Studies in
mouse models suggest that BL - 9020 can inhibit beta cell death in the pancreas, thus preventing full maturation
of Type 1
diabetes.
Morgan Fullerton, lead author
of the
study, added: «Unlike the majority
of studies using genetic
mouse models, we haven't deleted an entire protein; we have only made a very minor genetic mutation, equivalent to what might be seen in humans, thus highlighting the very precise way metformin lowers blood sugar in Type 2
Diabetes»
«We think that for the first time, we have a
mouse model of anorexia that closely resembles the conditions leading up to the disease in humans,» said
study leader Lori Zeltser, PhD, associate professor
of pathology & cell biology and a researcher in the Naomi Berrie
Diabetes Center.
«Natural killer cells help to drive inflammation, insulin resistance:
Study in
mouse models of diabetes identifies key immune mechanisms in abdominal fat.»
In the laboratory arm
of the Joslin
study, researchers
studied a
mouse model of human type 1
diabetes.
Harmonising ontological descriptions
of phenotype in
mouse and human and improving links between
mouse model data and human data, using
diabetes and obesity as examples, will increase the relevance
of data that is generated in
mouse studies for clinical
studies.
In the Joslin
study, scientists first examined gene expression in the hypothalamus
of a
mouse model of insulin - deficient (type 1)
diabetes.
The two labs are now collaborating on further
studies of the new enzymes — and the potential benefits
of inhibiting them — in
mouse models of diabetes, inflammation and autoimmune disease.
Studies using a
mouse model of type 1
diabetes highlight a potential role for human adipose stem cells in treatment regimens and, further, they reveal a secreted factor which has important therapeutic relevance