«We've developed a nationwide network capable of removing and
studying pancreatic tissue from organ donors as young as 6 months and as old as 66 within about a day and half after death.
Not exact matches
The researchers also anticipate that their gene expression data and newly described islet - cell isolation technique, coupled with the ongoing
tissue procurement effort, will be helpful to others
studying pancreatic development and diabetes.
But it's been nearly impossible to
study this process in detail because human
pancreatic tissue is not readily available.
On average, the
pancreatic cancer patients examined in the
study carried 15 LINE - 1 insertions in their tumor DNA that were not in healthy
tissue.
They have generated excitement over the past few decades because scientists can
study them in the laboratory to discover the genetic switches that control the development of specialized
tissues in the embryo and fetus, and also because of their potential to replace body
tissues that have broken down, such as
pancreatic cells in those with diabetes or heart muscle cells in those with congestive heart failure.
«The powerful
tissue resource used in this
study was made possible by generous financial donations from Teresa's Foundation for
Pancreatic Cancer and the Tim and Mary Ann McKenzie Chair of Surgical Oncology Professorship,» says Drifka.
Our previous
studies have demonstrated increased inflammation in adipose,
pancreatic tissue and mesenchymal stem cells isolated from bone marrow of WNIN / GR - Ob rats [14 - 16].
Bottom Line: Bacterial load was significantly higher in
pancreatic tumor samples from patients with
pancreatic ductal adenocarcinoma compared with
pancreatic tissue from normal individuals, and in
studies using mice, eliminating certain «bad» bacteria slowed the growth of
pancreatic cancer, reversed immune suppression, and upregulated the immune checkpoint protein PD1.