Sentences with phrase «studying patient samples»

Rao, together with senior author Michael Brenner, set out to explore these questions by studying patient samples in remarkable detail not achieved in earlier studies.

Not exact matches

The study, by Yusuke Tsugawa and colleagues at the Harvard T. H. Chan School of Public Health, Harvard Medical School, and other institutions, examined the record of a large random sample of Medicare patients, 65 years or older, who were hospitalized from January 2011 to December 2014.

Huntington's disease and other inherited brain conditions are challenging to study because it is difficult to obtain samples of neurons from living patients.

During this in depth study, an international team of researchers led by British scientists investigated the impact of anti-hormone therapy on samples taken from patients with prostate cancer.

This feasibility study examined 272 different proteins in 288 separate patient blood samples.

Patients with early - stage and advanced OA, RA or other inflammatory joint disease were recruited for the study alongside a control group of those with good skeletal health, with plasma and synovial fluid samples from both groups being analysed using mass spectrometry.

In collaboration with Anna Pyle, Howard Hughes Medical Institute investigator and professor in the Department of Molecular, Cellular and Developmental Biology at Yale, Patrizio and his team studied samples from 20 cumulus cells in 15 patients younger than age 35 and in those age 40 and older.

In a study from the University of Pennsylvania School of Nursing (Penn Nursing), a new, simplified Braden QD Scale now describes combined immobility - related and MDPI risk in a broader, more diverse sample of pediatric patients typically cared for in acute care environments.

This study analyzed preserved tumor samples from 43 prostate cancer patients who later received radiation therapy after rising PSA levels were detected following a radical prostatectomy.

In addition, rigorously designed studies of large and diverse patient samples are still needed to confirm the presence of these cytokine alterations, but if replicated, such findings could contribute to more personalized medicine for patients.

«Previous studies have demonstrated an association between stress and skin symptoms, but those studies relied on small patient samples, did not use standardized tools, are anecdotal in nature, or focused their analyses on a single skin disease,» says Gil Yosopovitch, MD, Chair of the Department of Dermatology at LKSOM, Director of the Temple Itch Center, and corresponding author of the study.

Tear samples from patients with diabetes show elevated levels of substance P, which are related to early damage to the corneal nerves, which may contribute to the development of corneal ulcers and poor wound healing in patients with diabetes, according to the pilot study by Maria Markoulli, PhD, MOptom, FAAO, and colleagues of University of New South Wales, Sydney, Australia.

Cancer researchers use the patient samples and information to study how cancer develops and discover better ways to treat it.

In this study, Nath and his colleagues compared serum samples from patients with Nodding syndrome and healthy controls who all lived in the same village in Uganda.

«From these archived nerve samples, we studied three adult patients with AIDP compared to three matched controls,» Ubogu said.

«We hope that our work will provide the basis for a larger study of patient samples that may ultimately identify biomarkers that can be used as surrogate markers to determine the benefit of therapeutic interventions in diagnosed but asymptomatic HD patients to prevent or delay disease onset.»

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

«Previous studies examined patients undergoing hip - fracture repair or other urgent surgeries, in which initial blood samples were collected after a significant stressor had already occurred,» she added.

To study the role of sweet taste receptors, Cohen and lead study author Robert J. Lee, PhD, a post doctoral researcher in his lab, partnered with colleagues from the Children's Hospital of Philadelphia and the Monell Chemical Senses Center to analyze cultures and tissue samples from the upper respiratory tract of patients who were undergoing sinonasal surgery for a variety of conditions.

They reached out to clinicians worldwide to identify patients with arhinia — before this study only 80 cases had been reported during the past century — and gathered samples for genetic sequencing.

For the study, Bég recruited 100 of her patients who volunteered clinical samples for testing.

In a 2011 study, Hall analyzed blood samples taken as part of an earlier study of 112 patients with mild IBS, examining each person's COMT recipe.

The MGH team has assembled a large number of DNA samples from HD patients who contributed them for research to the Massachusetts HD Center Without Walls and through collaboration with the Huntington Study Group.

As a first step in the current study, the researchers genotyped 977 HD patients and then ran a second scan of samples from another 974 patients.

In this study, rather than studying one iPS cell line, the researchers derived and sequenced 10 iPS cell clones from each patient tissue sample to get a better understanding of mitochondrial DNA mutation rates.

Although the results are favorable, Cook noted the study has limitations, including the size of the patient sample studied.

The NIAID study involved 31 nasal samples from patients with CJD and 43 nasal samples from patients who had other neurologic diseases or no neurologic disease at all.

Spearheaded by first author Christopher McNair, PhD, a graduate student in the laboratory of Dr. Knudsen, the study undertook an extensive analysis of tumor samples and cell - free DNA samples from patients with advanced, lethal - stage prostate cancer.

Instead of gathering and testing patients in person, as in traditional studies, 23andMe researchers turned to online Parkinson's support groups to subscribe 3,426 patients, free of charge, to their service, which uses a mailed - in spit sample to identify genetic traits and disease risk factors.

Most patients in our sample overdosed on prescription opioids, suggesting that further efforts to stem the prescription opioid overdose epidemic are urgently needed,» the study concludes.

To this end, Aucott and his group are currently analyzing cognitive testing results and blood samples taken from patients who participated in this study to search for research biomarkers that were not examined in the initial study.

A global analysis of metabolites and small molecules in urine samples from patients with adrenal cancer has identified four biochemicals that, when measured together, can distinguish malignant from benign adrenal tumors, according to study results presented at the 2015 Annual Clinical Congress of the American College of Surgeons.

Although the study sample is small, these data suggest that glutamate levels in the LDLPFC are associated with alcohol - craving intensity in patients with AUDs.

The researchers analyzed the samples using immunohistochemistry and RNA sequencing to study the changes in the tumor immune microenvironment of patients who received and did not receive chemotherapy, and changes before and after chemotherapy.

«After our animal studies showed that GM - CSF was important in the development of an MS - like disease, we were excited to see these results confirmed using samples from MS patients in the current study,» says Abdolmohamad Rostami, M.D., Ph.D., Chair of the Department of Neurology at Thomas Jefferson University and director of its neuroimmunology laboratory.

Leite said the main problems with this study are the small sample size, the fact that patients were studied retrospectively, and the lack of pathological data from placenta samples.

In the new study, to test whether the same observation was true in humans, Dr. Rostami and colleagues tested blood samples of patients with MS who had not yet received therapy, and those currently being treated with INF - β, a commonly used therapy.

For this project, researchers studied samples from 98 colorectal cancer patients with different mutations in KRAS and BRAF genes.

The study divides 177 blood and 27 post-mortem brain samples into several groups, establishing that careful analysis of RNA transcripts in blood samples has the ability to distinguish early clinical AD, Parkinson's disease (PD), and cognitively healthy patients.

Because injuries and surgeries can trigger rapid bone formation in FOP patients, obtaining tissue samples for extensive lab study is extremely difficult.

Biochemist Richard Thompson, PhD, along with his colleague from University College, London, Imre Lengyel, PhD, and a multidisciplinary international team studied retinal samples from a group of elderly patients, some of whom had AMD.

«In this study, we decided to find out if pre-operative, prophylactic antibiotic concentrations in joint fluid samples from patients were sufficient to prevent Staphylococcus aureus and MRSA contamination,» said Noreen Hickok, Ph.D., Associate Professor in the Department of Orthopedic Surgery in the Sidney Kimmel Medical College at Thomas Jefferson University.

The FDA authorized marketing the Brain Trauma Indicator after examining data from a clinical study of nearly 2,000 blood samples from patients with suspected concussions.

In her study, Dr. Dadachova and a team of researchers administered RIT to blood samples from 15 HIV patients treated with HAART at the Einstein - Montefiore Center for AIDS Research.

Building on this research in their latest study, the team analysed liver samples from 2000 patients with Hepatitis C, using state - of - the art genetic and functional analysis, to determine the specific IFNL protein responsible for liver fibrosis.

The study analyzed health insurance claims data for a national sample of privately insured patients in 2011.

Academics need companies to supply the drugs, extensive patient populations, and their associated DNA samples — and sometimes funding — for a study.

In the study, researchers analyzed data for patients age 80 and older, and those ages 65 to 79, from the Nationwide Inpatient Sample (NIS).

In a study of 40 patients with high grade serous ovarian cancer, the researchers monitored tumour DNA that could be detected in a blood sample taken before each chemotherapy treatment.

«Educating staff is essential to the process of improving patient outcomes, and the results of our study showed the relationship between education and sampling of lactate and blood cultures as well as timeliness of antibiotic administration.»