Not exact matches
If you can understand the importance
of case
studies, you'll be well - equipped to put them into action and make the necessary
changes to improve conversion
rates.
These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount
of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability
of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction
of generic versions
of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect
of lowering prices or reducing the number
of insured patients; the possibility
of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels
of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits
of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages
of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical
studies may not warrant further development
of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to
changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange
rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
Mark Maassel, president
of IEA, admitted to the IndyStar that no
study had been done to justify the
change to the net metering
rates and the need for the legislation.
I saw a
study that showed the annual
rate of change in real wages, where «real wages» is calculated using a «real» inflation
rate, is declining.
And because all CDs lock up your deposit for a fixed length
of time, you can also save money by
studying how average CD
rates have
changed in the recent past.
Church attendance
rates by Christians in the United States have stayed largely steady since the 1970s, but there have been some significant
changes in the makeup
of the congregations in the pews during that time, a recently released
study says.
We have previously described
studies of pacing strategy using various experimental interventions, including faster and slower starts, higher temperatures, hypoxia, hyperoxia and altered energy substrate availability.1 We have proposed the presence
of a complex, regulatory system that mediates
changes to skeletal muscle motor unit activation and work
rate in order both to optimise performance and prevent potentially harmful
changes to homeostasis.
Recent qualitative and quantitative
studies have confirmed MomsTEAM's longstanding belief that, more than education about concussion signs and symptoms, it is
changing the negative attitude
of too many coaches towards reporting and creating a safe concussion - reporting environment that may be the best ways to improve the low
rates of self - reporting found in
study after
study.
Estimates
of the numbers
of women booked for home birth but delivering in hospital were even more difficult to obtain because hospital records do not always specify this information accurately and no national estimate exists.1 4 Data collected in this region in 1983 suggested that 35 %
of these women
changed to hospital based care either before or during labour, and a more detailed prospective
study of all planned home births in 1993 found a total transfer
rate of 43 %.8 Women were classified as having booked for a home birth when a community midwife had accepted a woman for home delivery and had this arrangement accepted by her manager and supervisor
of midwives at any stage in pregnancy, irrespective
of any later
change of plan.
A final
study, which also reported on fetal distress, found hyperstimulation with fetal heart
rate changes in 2.9 %
of women using nipple stimulation, compared to 1 %
of women using pitocin.
The increased socioeconomic inequalities in breastfeeding observed in the intervention group supports the argument that population intervention strategies could inadvertently exacerbate, rather than mitigate, socioeconomic inequalities, particularly when the intervention aims to
change individual behaviours rather than targeting «upstream» structural
changes.25 Our results are also compatible with an observational
study from Brazil reporting that breastfeeding
rates increased first among the socioeconomically better - off, followed by increases among the poor, over a 20 - year period
of active breastfeeding promotion campaigns in Brazil.26
The results
of the company's
study showed the district could save money by
changing some
of its
rate packages for utilities.
Hospitals that transitioned from not having DHM to having DHM availability during the
study period were examined to assess
changes in
rates of breast milk feeding at NICU discharge and NEC.The availability
of DHM increased from 27 to 55 hospitals during the
study period.
Is anyone else curious about what the
rate of reporting was — or if / how it
changed — from the beginning
of the
study to the end?
The
study, by welfare - to - work consultancy Policy in Practice, also suggests that the
changes would leave recipients facing tax
rates of 93 % on their additional earnings.
The UK's most respected independent tax and spend monitor, the Institute for Fiscal
Studies, said today the
changes brought in by the comprehensive spending review would «clearly» hit the poorest harder than the better off and be «regressive» without the increase in the higher
rate of tax introduced by Labour.
Study after study after study has shown no significant pattern of wealthy people moving from high - tax to low - tax states, and no noticeable change in the net migration rates of high earners between US states in the wake of changes in their relative tax r
Study after
study after study has shown no significant pattern of wealthy people moving from high - tax to low - tax states, and no noticeable change in the net migration rates of high earners between US states in the wake of changes in their relative tax r
study after
study has shown no significant pattern of wealthy people moving from high - tax to low - tax states, and no noticeable change in the net migration rates of high earners between US states in the wake of changes in their relative tax r
study has shown no significant pattern
of wealthy people moving from high - tax to low - tax states, and no noticeable
change in the net migration
rates of high earners between US states in the wake
of changes in their relative tax
rates.
The analysis uncovered major
changes in population growth; with the exception
of wolves, all species experienced a drop in population growth
rates immediately following the collapse, and three species — wild boar, moose, and brown bears — exhibited significant reductions in population growth throughout the decade following the collapse, with declines evident in 85 % or more
of the
study regions.
Published this week in Nature Climate
Change, the initial
study finds that embankments constructed since the 1960s are primarily to blame for lower land elevations along the Ganges - Brahmaputra River Delta, with some areas experiencing more than twice the
rate of the most worrisome sea - level rise projections from the United Nations» Intergovernmental Panel on Climate
Change.
Barry Sinervo, a reptile and ecology expert at the University
of California, Santa Cruz, who was not involved with the recent
study, pointed to some
of his own research, such as a
study published in Science in May 2010 that examined extinction
rates in lizards alongside
changing climatic conditions.
The opportunity to
study discs that existed so long ago could help reveal how the
rate of planet formation across the universe has
changed over time, says Mentuch.
No time to adapt In terms
of adaptation, the
rate of climate
change might be more important than how much the climate
changes, said Alan Robock, a climate scientist at Rutgers University who ran some
of the models for the
study.
Results showed that, among
study participants with asymmetry in temporal lobe high frequency electrical activity, those with right compared to left side asymmetry had higher resting heart
rates and other
changes suggesting that the cardiovascular system may be less capable
of adapting to shifting circumstances.
Climate
change may be harming the future
of African wild dogs (Lycaon pictus) by impacting the survival
rates of pups, according to one
of the first
studies on how shifting temperatures are impacting tropical species.
For example, he says, although the new
study found no overall
change in the
rate of melting at Totten Glacier over the last couple
of decades, the large variability in melting
rate within those decades warrants a much closer look at the region's complex topography, among other factors, in order to anticipate how the system could actually
change in the future.
The
study, which used geolocated crime data to examine
changes in crime volume in the immediate neighborhood
of the casino since its opening, found that crime
rates in the Fishtown neighborhood
of Philadelphia were largely unaffected by the introduction
of the gaming establishment.
The sturgeon finding is just one result in a wide - ranging
study of the
rates of species formation and anatomical
change in fish.
Given widespread observation
of habitat
change and individual species declines — and knowing that extinction
rates are many times higher than normal — the scientists predicted a drop, over time, in the number
of species observed in most
of these
studies.
Past
studies of overflight impacts have documented penguins running away from nests, executing «head movements,» and
changing heart
rates and body temperatures.
«In
studying one
of the most dramatic episodes
of global
change since the end
of the age
of the dinosaurs, these scientists show that we are currently in uncharted territory in the
rate carbon is being released into the atmosphere and oceans,» says Candace Major, program director in the National Science Foundation (NSF)'s Division
of Ocean Sciences, which funded the research.
Scientific experiments to measure the
rate and effects
of climate
change on plants aren't matching up to what is happening in nature, a new
study finds.
A new University
of Iowa
study in mice shows that drug - induced
changes to the gut microbiome can cause obesity by reducing the resting metabolic
rate — the calories burned while sleeping or resting.
The
study used data from the Current Population Survey to investigate if the dramatic decrease between 1993 and 2001, and equally dramatic increase between 2001 and 2010, in the child poverty
rate could be attributed to
changes in the proportion
of children in immigrant families.
To look at the
rate of change in working memory in relation to different measures
of socioeconomic status, the researchers
studied more than three hundred 10 - through 13 - year - olds from urban public and parochial schools over four years.
The authors are quick to point out that climate
change is still detrimentally affecting the habitats
of those species, but at a much slower
rate than dozens
of previous
studies forecast.
«The probability
of this
rate change occurring randomly is approximately 0.16 %,» Rubinstein and colleagues write in the BSSA
study.
This is the largest cohort
study to analyze
changes in
rates of pre-eclampsia in the U.S.
He also cited neuroimaging
studies showing that prolonged periods
of reduced audio stimulation can lead to faster
rates of atrophy,
changing the brain's structure Additionally, social isolation caused by hearing loss may contribute to further brain decline, Lin said.
To conduct the
study, the researchers used the so - called «differences in differences» methodology to analyze the
changing rates of patent activity in the 34 states with constituency statutes, versus activity
rates in the 16 states lacking them.
In addition, while it has been suggested that a
changing climate can exacerbate the effects
of air pollution and increase death
rates, the
study shows that this has a minimal effect and only accounts for a small proportion
of current deaths related to air pollution.
A new
study by University
of Southern California and Yale University researchers suggests that at least part
of the gains in life expectancy over recent decades may be due to a
change in the
rate of biological aging, rather than simply keeping ailing people alive.
Additional
studies are needed to determine what specific
changes in care have had the most impact on decreasing the mortality
rates of patients with severe sepsis.
The population
of cities in the
studied region grew annually, on average, at 2.8 %, in contrast to the
rates of change for urban land average, which grew 2.0 % annually.
A new
study now shows that history
of TBI (with loss
of consciousness) does not appear to affect the
rate of cognitive
change over time for participants with normal cognition or even those with AD dementia.
Dr. Lisa Osborne, a clinical researcher and co-author
of the
study, said: «A problem with experiencing physiological
changes like increased heart
rate is that they can be misinterpreted as something more physically threatening, especially by those with high levels
of anxiety, which can lead to more anxiety, and more need to reduce it.»
The complex geology and high
rates of biodiversity in the region — currently home to an estimated 7,452 plant and animal species — make it a potential «natural stronghold» in the fight against climate
change, according to a new, multimillion - dollar
study by the Nature Conservancy.
According to their report, released in October, the subjects showed unusual
changes in their lung tissue at roughly eight times the
rate seen in a
study of similarly aged transportation workers, although these could have had many causes.
In both
studies, adding the second drug did not
change kidney function or
rate of increase in kidney cyst size.
One
of the most striking findings, according to
study authors, was the
change in smoking
rates, which increased from 28 to 46 percent — a finding counter to national trends, which reflect an overall decline in smoking
rates over the past 20 years.
This
study's simulations show that the drying
rate changes according to the shape
of the air - water interface located near the surface.