Palczewski, a vision scientist, and Lu, who
studies drug delivery, have worked together on this research for six years.
The researchers were
studying the drug delivery system at the cellular level and hope to continue the research with future animal studies.
Not exact matches
Phase I funding — which allows up to $ 250,000 for an academic idea, such as decoding the genetic sequence of a protein or
studying targeted
drug delivery by using magnetic nanoparticles — is available from federal funding and foundations.
There were no differences between groups in the gestational age at randomization, time to uterine quiescence, time on
study drug, length of hospitalization, days from randomization to
delivery, incidence of side effects, or admissions to the neonatal intensive care unit.
PFC was one of the initial
study sites for FDA approval of the Follistim Pen, an FSH medication
delivery device that today has made fertility
drug administration much easier and comfortable for patients and is now widely used for ovarian stimulation.
Many women don't want to deliver in a hospital because they fear their choices — to avoid
drugs, to avoid surgery, to be surrounded by their families, to be with the baby immediately after
delivery — will be taken away, said Carolyn L. Gegor, program director of the Nurse Midwifery / Women's Health Nurse Practitioner Program in the School of Nursing and Health
Studies at Georgetown University Medical Center.
Hannes Stockinger, the senior author of the
study, adds: «If we coupled this
delivery method with screening of patient's tumours for the presence of a unique surface protein, which we can target with the Fab fragment - functionalized liposomes, we might be able to treat tumours more efficiently and decrease the side effects of the delivered anti-cancer
drugs substantially.
Dr. McCabe said nanoparticles are a leading - edge technology also being
studied for
delivery of
drugs for other conditions, such as cancer, heart disease, and bacterial infections, in order to target specific cells to reduce toxicity and side effects of those medications and to make them more effective.
«Future comparative oncology
studies, optimizing the
delivery of PMed strategies, may aid cancer
drug development.»
There are multiple techniques currently being
studied for this type of
drug delivery mechanism, from microneedles to iontophoresis (transdermal
drug delivery via electric current), but the Kumamoto University researchers designed to improve a technique called transdermal thermal ablation.
The findings will likely guide future
studies not only on the potential of nanodiamonds in
drug delivery but also on fighting bacteria and treating viral diseases.
The
study involved 21 women randomly assigned to receive a 60 - hour infusion of the
drug or a placebo within six months after
delivery.
In a separate
study, Discher and colleagues tested whether their approach could improve the
delivery of
drugs.
«There are a lot of questions about how to implement it,» says Connie Celum, an HIV researcher at the University of Washington in Seattle, who led a large trial of the
drug in East Africa and has begun
studies to answer practical
delivery questions, such as which subsets of people are at highest risk.
In a
study using mice, the researchers found that using Dox and TRAIL in the pseudo-platelet
drug delivery system was significantly more effective against large tumors and circulating tumor cells than using Dox and TRAIL in a nano - gel
delivery system without the platelet membrane.
Added Robert Rieben, PhD, associate professor of Transplantation Immunology, Department of Clinical Research, University of Bern, co-corresponding
study author: «Continuous release of the
drugs irrespective of disease severity is a hallmark of existing
drug delivery vehicles and could be a thing of the past.
Initiating
drug therapy during pregnancy caused rapid declines in viral load, but more than 95 percent of women
studied reported at least one side effect before
delivery, which may lower adherence.
A new
study shows that a 70 - year - old malaria
drug can block immune cells in the liver so nanoparticles can arrive at their intended tumor site, overcoming a significant hurdle of targeted
drug delivery, according to a team of researchers led by Houston Methodist.
«Human chronobiome»
study informs timing of
drug delivery, precision medicine approaches.»
Prior
studies suggested that nanoparticle
drug delivery might improve the therapeutic response to anticancer
drugs and allow the simultaneous monitoring of
drug uptake by tumors.
Nanoparticles are being
studied as
drug delivery systems to treat a wide variety of diseases.
«The failure rate to deliver
drugs to CNS is unfortunately very high, so any new methods of
drug, protein and gene
delivery should be welcome,» says Inder Verma, Ph.D., a professor in the Laboratory of Genetics and senior author of the
study published in the Proceedings of the National Academy of Sciences.
Shahab explaines the
study's findings would pave the way for designing more - efficient
drug delivery capsules in the future, especially those that can be activated by focused ultrasound waves.
«Our work sets the stage for researchers interested in
studying the fundamental properties of interesting materials and applied systems, such as solar cells, batteries, sensors, paints and
drug delivery systems,» said Dichtel, the Robert L. Letsinger Professor of Chemistry at the Weinberg College of Arts and Sciences.
CCHa2 could provide an ideal model for the
study of BBB function as well as
drug delivery across the BBB.
In their
study, published in the October issue of Biomaterials Science, the researchers built a
drug delivery system using apoferritin, the same ball of natural proteins that carries iron around in blood without letting the iron leak out.
Jessica Tucker, program director of
Drug and Gene
Delivery and Devices at the National Institute of Biomedical Imaging and Bioengineering, which is part of the National Institutes of Health, said the approach outlined in the
study has the ability to combine both imaging and therapeutic applications in a single platform, which has been difficult to achieve, especially in an organic, and therefore biocompatible, vehicle.
In his own lab, he is focused on improving the affinity of the meditope - Fab hitch, developing multivalent meditopes for imaging and
drug delivery and beginning pre-clinical
studies.
In a
study to be published in the May 23 print issue of the journal Small (and currently available online [abstract]-RRB-, they demonstrate the ability to package
drug - loaded «nanodisks» into vault nanoparticles, naturally occurring nanoscale capsules that have been engineered for therapeutic
drug delivery.
Wimberly decided to continue his
study of genetics and
drug delivery at Samulski's alma mater after turning down Emory, Vanderbilt, USC, UCLA, the University of Colorado, and Alabama - Birmingham.
Solomon Diamond, PhD, and Todd Miller, PhD, received a joint Prouty grant to
study image - guided
drug delivery that relies on magnetic tags and imaging methods.
Mooney uses the results from these
studies to design and synthesize new biomaterials that regulate the gene expression of interacting cells for a variety of tissue engineering and
drug delivery projects.