Sentences with word «subcellular»

The word "subcellular" refers to something that is smaller or exists within a cell. It describes structures or processes that occur inside the cell at a microscopic level. Full definition
Because DDX3 exhibits tumor suppressor functions, such as a growth - suppressive property and transcriptional activation of the p21waf1 / cip1 promoter, and is inactivated through down - regulation of gene expression or alteration of subcellular localization in tumor cells, all these features together suggest that DDX3 might be a candidate tumor suppressor.
And nanoscale imaging of the brain promises to open up a brave new world of questions about brain function and structure on a cellular and subcellular level.
Additionally, an alteration of subcellular localization from nuclei to cytoplasm was also observed in > 70 % of cutaneous squamous cell carcinoma samples.
The ability to label different subcellular locations with the green fluorescent protein (GFP) has made it possible to visualize intracellular activities in living cells.
Now, a team led by engineers at Tufts University School of Engineering has opened a window into the cell by developing an optical tool that can read metabolism at subcellular resolution, without having to perturb cells with contrast agents, or destroy them to conduct assays.
The article describes a novel image - based screen to identify compounds that increase SMN protein levels in subcellular compartments of intact cells.
The first version of Project Discovery will include classification of patterns of protein subcellular distribution in human cell lines.
Confocal microscopy of convertases and known disease - related human convertase mutants in cells and tissues will also be used to shed light on subcellular targeting mechanisms.
A friend of mine relates how, when he was in college, he was using electron microscopy to look at subcellular organelles.
«We expect that our new method will become an attractive tool to study energy requirements of living systems with subcellular resolution,» says Min, «especially in brain and malignant tumors that are in high demand of energy.»
The combination allows for the study of 3D subcellular processes in their native multicellular environments at high spatiotemporal (space and time) resolution.
We study how subcellular dynamics contribute to the expansion of skull bones and migration of osteoblasts.
In the first step, stainings in different cell lines with the same antibody are reviewed and the results are compared with available protein / gene characterization data for subcellular location.
They can also track standard molecular markers for mitochondria, nuclei, and other subcellular structures.
The third and newest approach to liquid biopsies, exosome screening, relies on circulating subcellular vesicles.
In the PROSPECTS project new or improved tools and approaches have been developed to enable absolute protein quantification, study of protein - protein interactions and protein complexes and the quantitative study of protein abundance and turnover rates in different subcellular localizations at a proteome - wide level.
The core facility is a two - photon in vivo imaging platform developed at the Nonlinear bioimaging laboratory, a technique that allows for non-invasive structural and functional measurements in small animal models at different scales: from macroscopic imaging of the brain morphology to highly resolved microscopy of neuron populations, single neurons, and even subcellular structures.
Starting from simple secretory vesicles, which released enzymes and adhesive proteins to attach to and digest other cells, highly complex subcellular weapons systems in cnidarians and dinoflagellate genes presumably developed in different ways.
Recently, Daniels et al. (10) elegantly showed that positive selection signals induced subcellular compartmentalization of RasGRP / Ras / ERK to the Golgi membrane, whereas negative selection signals induced localization of Grb2 - Sos / Ras / ERK to the plasma membrane.
Understanding the molecular connections between the local regulation of subcellular homeostasis and axon morphogenesis is therefore a critical challenge in cellular neurobiology.
Adaptive optical lattice light - sheet microscopy permits delicate 3D subcellular processes to be viewed natively in vivo.
Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms
Miniscule carriers, the motor proteins, slide along the microtubules with great volumes such as chromosomes, vesicles and other subcellular components — like mitochondria — latched onto them.
This webinar will introduce viewers to the process of using IFC to determine subcellular localization of biomarkers, including a discussion of how IFC can help to assess the activity of transcription factors, or the drug - induced stimulation or inhibition thereof, in clinical samples.
To avoid such perturbations, researchers have developed a computer program that can distinguish between cell types and identify subcellular structures, among other features — all without the fluorescent probes our human eyes rely on.
Abstract Synapses are organized subcellular structures that transmit information within the nervous system and to other parts of our body.
Her doctoral research was conducted in the laboratory of Erik Lee Snapp and focused on optimizing fluorescent proteins for subcellular environment.
However, conventional light sheets are too thick over cellular dimensions to capture subcellular workings in detail, at high resolution.
Showed that the nucleus is a critical subcellular site in which mutant huntingtin induces neurodegeneration.
The group also found that mNeonGreen works well for GFP's typical applications, from tagging proteins to labelling subcellular compartments, and that the protein is as stable against photodegradation as GFP.
The only problem is none of these planets are remotely in a position to support subcellular life.
Combining minimally invasive lattice light - sheet microscopy with adaptive optics to counter optical aberrations present in multicellular specimens enables the study of rapid subcellular processes at high resolution within living organisms, where all environmental factors that regulate cellular physiology are present.
These results suggest roles for β - arrestins in mediating the intracellular transport of a 7TMR to its obligate subcellular location for signaling.
A pioneer of modern cell biology used cell fractionation and electron microscopy to describe subcellular structures.
For them, that exercise might seem equivalent to pondering whether those individual subcellular constituents are alive on their own.
Qi wanted to determine if the peptide had more than subcellular effects, and if it could be used therapeutically to prevent Huntington's disease symptoms.
In addition, Finns have reduced variability in DNA from mitochondria, subcellular energy - producing machines inherited from the mother.
«The cytoskeleton system is comprised of a host of interacting subcellular structures and proteins, and our technique will enable research on the interactions between these different targets with unprecedented number of color channels and spatial resolution,» he said.
The new method yields an enhanced image quality, which is advantageous when analyzing three - dimensional, densely arranged subcellular structures.
Normally, the calcium is located outside the cell or in tiny subcellular compartments called mitochondria.
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