"Subcellular localization" refers to the specific area or compartment within a cell where a particular molecule or protein is located. It helps scientists understand where different molecules work and how they interact within a cell.
Full definition
Deputy Editor Steven Carr of The Broad Institute will talk about new approaches for
subcellular localization of proteins and their interaction partners with high spatial resolution.
Questions remain concerning why neurons that apparently express similar innexins (the different motor neuron classes) rarely form gap junctions with one another, if gap junctions are subject to constant formation and reformation in the nervous system, and why there appears to be a consistency
in subcellular localization (soma versus process) of certain gap junctions.
Sina Koch (Ehninger, TUD)-- «
Aberrant subcellular localization as a potential mechanism contributing to the abnormal signaling of the mutant Flt3 - ITd receptor tyrosine kinase in acute myeloid leukemia» (2007)
This webinar will introduce viewers to the process of using IFC to
determine subcellular localization of biomarkers, including a discussion of how IFC can help to assess the activity of transcription factors, or the drug - induced stimulation or inhibition thereof, in clinical samples.
Additionally, an alteration of
subcellular localization from nuclei to cytoplasm was also observed in > 70 % of cutaneous squamous cell carcinoma samples.
Additionally, alterations of
subcellular localization through aberrant splicing or genetic mutations also provide ways to inactivate tumor suppressor genes (50).
In the PROSPECTS project new or improved tools and approaches have been developed to enable absolute protein quantification, study of protein - protein interactions and protein complexes and the quantitative study of protein abundance and turnover rates in
different subcellular localizations at a proteome - wide level.
Interferon regulatory
factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA - binding domain and interaction with cytoplasmic retention factors
Thus, a change in
the subcellular localization of CED - 4 may drive programmed cell death.
Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity.
Because DDX3 exhibits tumor suppressor functions, such as a growth - suppressive property and transcriptional activation of the p21waf1 / cip1 promoter, and is inactivated through down - regulation of gene expression or alteration of
subcellular localization in tumor cells, all these features together suggest that DDX3 might be a candidate tumor suppressor.
Lysates from these two cell populations were fractionated on the basis of
the subcellular localization using the ProteoExtract Kit, and 40 μg of proteins was loaded for Western blotting.
A and B, phosphorylation and
subcellular localization of mTOR signaling proteins in ALCL cell lines.
Our results clearly indicate that the expression of DDX3 is decreased in HCC and
the subcellular localization of DDX3 is altered in cutaneous SCC (see Figs. 5 and 6).
The biological significance of
the subcellular localization of p - p70S6K in ALCL is uncertain.
Identifying
the subcellular localization of huntingtin and understanding its effects on global gene expression are critical to this endeavor.
In the second step, all antibodies targeting the same protein are taken in consideration for final annotation of
the subcellular localization.
Distribution and
subcellular localization of glucocorticoid receptor immunoreactive neurons in the developing and adult male zebra finch brain.
Distinguish between models for trafficking to the lysosome by fusing Medium - FT to LAMP - 2A, a lysosome - associated membrane protein, and following
its subcellular localization overtime (Subach et al..)
Several highly conserved residues in SERT have been shown to be critical for
its subcellular localization, and mutation of these sites may contribute to both obsessive - compulsive disorder (OCD) and autism.