"Subcellular structures" refers to the various components and parts that make up a cell, such as organelles (nucleus, mitochondria, etc.) or molecules (proteins, DNA, etc.). They are the tiny building blocks within a cell that perform specific functions to keep the cell alive and healthy.
Full definition
Only within the past few years were members of the project able to start classifying, annotating and analyzing the millions of images they had captured of
subcellular structures in different cell types.
«The cytoskeleton system is comprised of a host of
interacting subcellular structures and proteins, and our technique will enable research on the interactions between these different targets with unprecedented number of color channels and spatial resolution,» he said.
But the crescent - shaped C. moniliferum caught Krejci's eye because of its unusual ability to remove strontium from water, depositing it in crystals that form in
subcellular structures known as vacuoles — an knack that could include the radioactive isotope strontium 90.
Examples include imaging techniques ranging from confocal advances to cryotomography — which can
resolve subcellular structure and reveal microbial cell function — and ways to monitor the production and exchange of microbial metabolites.
Sattarzadeh, A., Schmelzer, E., and Hanson, M. R. (2013) Arabidopsis myosin XI sub-domains homologous to the yeast myo2p organelle inheritance sub-domain
target subcellular structures in plant cells, Frontiers in plant science 4, 407.
To avoid such perturbations, researchers have developed a computer program that can distinguish between cell types and
identify subcellular structures, among other features — all without the fluorescent probes our human eyes rely on.
The core facility is a two - photon in vivo imaging platform developed at the Nonlinear bioimaging laboratory, a technique that allows for non-invasive structural and functional measurements in small animal models at different scales: from macroscopic imaging of the brain morphology to highly resolved microscopy of neuron populations, single neurons, and
even subcellular structures.
We have investigated whether myosins are involved in movement of stromules, plastids, mitochondria, peroxisomes, and
other subcellular structures.
An intriguing new study of
their subcellular structure could help explain how bipolar synaptic terminals meet such excessive energy demands.
Indeed, using four dyes to label four different
subcellular structures, such as mitochondria and microtubules, they were able to easily distinguish molecules of different dyes based on their spectral mean alone, and each subcellular structure was a distinct color.
A high - resolution map of the human cell has been generated — part of the Human Protein Atlas database — that provides the in situ localization of 12,036 human proteins at a single - cell level, covering 30
subcellular structures, and enabling 14 major organelle proteomes to be defined.
Importantly, they observed a significant disruption of the assembly of the axon initial segment (AIS),
a subcellular structure in the proximal part of the axon important for clustering of ion channels, and thus, for neurons to fire action potentials.
Turning their attention to the single - cell level, they mapped more than 12,000 proteins to 30
subcellular structures, in turn defining the proteomes — the complete sets of expressed proteins — of more than a dozen major organelles.
We use modern microscopy techniques to examine how chloroplasts and mitochondria interact with each other and other
subcellular structures.
The paper reports a wide variety of applications of the Enhanced Nano - Lanterns including monitoring multiple cellular events such as the dynamics of
subcellular structures and gene expression.