Nonetheless, sustained attention assessed via the 5 - CSRTT and working memory assessed via the DMTP task, appeared insensitive to
subchronic PCP exposure.
A 91 - day
subchronic toxicity study was conducted in male and female Sprague - Dawley rats following FDA Redbook protocols.
Other studies have shown its ability to help with mercury poisoning and
subchronic TCDD exposure.
What we're finding is that
subchronic levels of LPS circulating in the blood causes this chronic inflammation cascade.
Subchronic oral toxicity of a standardized white kidney bean (Phaseolus vulgaris) extract in rats
This study is the first to compare the effects of the well - known DPP - IV inhibitors diprotin A and sitagliptin on emotional and motivational behavior in rats
after subchronic intraperitoneal administration of the drugs in the early postnatal period.
Methods: Subjects were exposed to vehicle or
subchronic PCP at various doses (4 - 10 mg / kg / day) for 5 - 7 days followed by variable wash - out periods (1 - 5 days) in different studies.
Results:
Subchronic PCP treatment induced deficits in episodic memory, cognitive flexibility and social functioning, assessed via the novel object recognition, cued reversal learning and social interaction tests.
In the present studies, we assessed the effects of acute and
subchronic PCP in a range of assays relevant to the cognitive impairments associated with schizophrenia and the negative symptoms of schizophrenia in rats.
The researchers found the ancient spice was able to attenuate liver injury induced by ethanol, iron overdose, cholestasis and acute,
subchronic and chronic carbon tetrachloride intoxication.