Sentences with word «subcomplex»

The researchers determined that the propeller - shaped ISRIB molecule fits snugly into a pocket deep inside eIF2B where it holds together two identical subcomplexes of the larger protein.

The researchers saw that the propeller - shaped ISRIB sits deep inside eIF2B and acts as a molecular staple to pin two identical subcomplexes together.

The project focuses on the dynamics of transient microcompartments formed by the V - ATPase holoenzyme, V - ATPase subcomplexes and subunits together with the mentioned proteins, with the aim to understand the mechanisms leading to this unique type of physiologically relevant regulation.

Determination of the structure of the entire complex was possible only through this step - by - step approach, building on from smaller subcomplexes towards the entire assembly.

We show here that the S. cerevisiae Csm1 / Lrs4 monopolin subcomplex has a distinctive V - shaped structure, with two pairs of protein - protein interaction domains positioned approximately 10 nm apart.

Vps34 activity in autophagy is tightly controlled by assembling the autophagy specific class III PI3K subcomplex (Vps34 / p150 / BECN1 / ATG14)[66,67,71 - 74].

Not only must the complex locate subordinate subcomplexes, but it must itself be a subcomplex of another, perhaps more pervasive, complex.

An electron density map obtained from crystals of a subcomplex of yeast mitochondrial ATP synthase shows a ring of 10 c subunits.

We start with a bunch of protein subunits and the chaperones function as the tools that assist in the building of subcomplexes, which are like the dresser's drawers and frame.

Experiments and mathematical models showed these chaperones are important to prevent a subcomplex known as the regulatory particle from combining with the core particle before the particle is fully formed.

For this purpose analyze, on the one hand, the interaction of the V - ATPase, its subcomplexes and subunits with the mentioned proteins biochemically and by cryo - electron microscopy.