Sentences with phrase «subgenomic flavivirus»

The new study tests the effects of four other viruses: the two flaviviruses and two alphaviruses, chikungunya and Mayaro, which also have led to outbreaks in Zika - affected areas.

In general, examining the potential effects of other flaviviruses on pregnant women and their developing fetuses is difficult, because outbreaks have been sporadic and less widespread than with Zika.

The research, published and featured in the Spot Light section of the December edition of the Journal of Virology, examines a previously unknown connection between flaviviruses — a classification of viruses that include West Nile virus, Dengue virus and tick - borne encephalitis virus — and organelles (a specialized subunit within a cell) known as peroxisomes that help coordinate the body's immune responses.

According to the researchers, this latest work may now open new possibilities for intervention in flavivirus infection.

The researchers think it likely that other viruses may also target peroxisomes in a similar manner to flaviviruses.

Flaviviruses include West Nile virus and the virus that causes yellow fever, as well as Dengue virus.

Zika, dengue and other related viruses, known as flaviviruses, all use a version of NS3 to chop joined proteins apart so they can do their jobs.

Unfortunately, many other viruses from the same family, known as flaviviruses, have similar versions of NS1 and can produce a false positive.

This is the first structure of any helicase bound to ATP from flaviviruses, a group including other well - known pathogens such as dengue, yellow fever, and West Nile viruses.

The assay does not detect chikungunya virus or flaviviruses such as dengue, yellow fever, or West Nile viruses.

Data used in the model consisted of information about the traits of flaviviruses — the family that includes Zika, yellow fever and dengue — and all the mosquito species that have ever been associated with them.

The new 3 - D structure, which was obtained using X-ray crystallography and electron microscopy, revealed that the outer surface of the Zika NS1 protein has substantially different electrical - charge properties than those of other flaviviruses — indicating it may interact differently with the members of an infected person's immune system.

Based on what they learned, they used the model to test the combination of Zika virus with all the mosquito species known to transmit at least one flavivirus.

«Researchers are still working to understand precisely how Zika and other flaviviruses interact with an infected person's immune system,» she said.

The scientists suggest that flavivirus helicases could have evolved a conserved motor to convert chemical energy from nucleoside triphosphate to mechanical energy to unwind their genetic material, but the motors of the flaviviruses move in distinct ways to access their genomic RNA.

Furthermore, the defects observed are specific to an infection by ZIKV, as other neurotropical viruses of the flavivirus family (West Nile virus, yellow fever,...) did not cause microcephaly, in contrast to Zika virus.

«In addition, this platform can be used to develop safe vaccine candidates for other flaviviruses such as Zika virus, where pregnant women are the target group for vaccination.»

Other flaviviruses, such as West Nile virus, are rapidly spreading around the globe.

Flaviviruses are considered dangerous emerging pathogens.

His group, led by first author and Heidelberg postdoctoral fellow Mirko Cortese, also found that Zika and dengue, both flaviviruses, use similar strategies to infect host cells.

The trial conducted at the WRAIR Clinical Trial Center in Silver Spring, Md., is assessing the impact of pre-existing flavivirus immunity in volunteers who had been vaccinated against yellow fever or Japanese encephalitis — both viral cousins to Zika — prior to receiving ZPIV.

The epidemic strain produced elevated amounts of subgenomic flavivirus RNA (sfRNA), a viral noncoding RNA, relative to amounts of genomic viral RNA.

Jingmenviruses were first described in 2014 and are related to flaviviruses — a large family of viruses that includes human pathogens such as yellow fever, West Nile and Japanese encephalitis viruses.

The PR - 2B DENV - 2 produced increased levels of subgenomic flavivirus RNA (sfRNA) relative to genomic RNA during replication.

Dengue fever is caused by a mosquito - transmitted flavivirus resembling Zika virus.

Further, current serologic tests often can't distinguish between related flavivirus infections in dengue - endemic regions.

The structure of mature Zika virus is similar to other flaviviruses, except in the region of a potential cell attachment site.

The structure reveals key interactions that probably contribute to the high catalytic efficiency of this enzyme relative to other flaviviruses, indicating promising starting points for drug design.

The structure is mainly similar to that of other flaviviruses such as dengue virus; however, there are differences in a region that may be involved in binding to host receptors.

The high - resolution structure of the Zika virus showed that the overall virus architecture is similar to other flaviviruses such as the West Nile and dengue viruses.

The structure of Zika virus is similar to other known flavivirus structures, except for the ~ 10 amino acids that surround the Asn154 glycosylation site in each of the 180 envelope glycoproteins that make up the icosahedral shell.

«We worked on the dengue virus 20 years ago, and when Zika popped up in the news, we knew immediately that the two mosquito - borne viruses were related members of the flavivirus family,» Robert Linhardt, Ph.D., says.

Zika virus is a flavivirus like the dengue, yellow fever, and West Nile viruses.

Zika virus (ZIKV), a mosquito - borne flavivirus with homology to Dengue virus (DENV), has become a public health emergency.

It notes some of the critical scientific questions regarding Zika that deserve further exploration, including: whether certain viral mutations occurred to facilitate its geographical spread; if different species of Aedes mosquitoes are capable of transmitting Zika and what that may mean for future transmission; what is apparently unique to Zika compared to other more well - known flaviviruses, such as dengue, that can explain why it can cause congenital infections, neurological conditions and encephalitis, transmit sexually and persist for long periods of time in multiple parts of the human body; and whether preexisting immunity to other related flaviviruses may impact Zika exposure and infection.

By analyzing the affected animals, the scientists isolated an aggressive new flavivirus, a class of viruses that includes yellow and dengue fevers — the first flavivirus ever identified in ducks.

«Most flaviviruses are zoonotic,» meaning they can be transmitted from animals to people, Gao says, «so infection of human beings can not be ruled out.»

In addition to potentially devastating Chinese duck farming and the economy that depends on it, the flavivirus could put humans at risk.

The researchers say the culture model will greatly increase knowledge about how flaviviruses infect ticks and could become a tool to evaluate medical countermeasures against tick - borne viruses.

Flaviviruses are the cause of diseases spread by mosquitoes (e.g., dengue fever and West Nile fever) and by ticks (e.g., Powassan virus disease and tick - borne encephalitis).

Gao and colleagues say the BYD virus is closely related to the Tembusu virus, a flavivirus found in Southeast Asia.

Powassan virus and the closely related deer tick virus are the only flaviviruses known to be spread by ticks in North America.

«Infection model developed for tickborne flaviviruses.»

Assays already exist to detect Zika virus infection, but they either work only shortly after infection or are poor at differentiating Zika from other flaviviruses.

When the assay was run on patients infected with Zika virus and also on a control group of 540 patients infected by other flaviviruses or other viruses, plus healthy donors, the specificity was 95.9 percent.

As of 30 November, more than 1200 cases had been reported in 10 states, all of which have also reported Zika virus infections, says Ana Maria Bispo de Filippis, head of the flavivirus laboratory at the Oswaldo Cruz Institute in Rio de Janeiro, Brazil.

None of the mothers reported being sick with Zika virus, but all four who were tested had antibodies to a flavivirus, the family to which Zika belongs.

«Prior dengue or yellow fever exposure does not worsen Zika infection in monkeys: Findings counter some concerns that prior flavivirus disease primes immune system to enhance Zika infection.»

The assay was implemented in five countries and tested using a large number of clinical samples from travelers and patients living in areas with a high level of exposure to Zika virus and other flaviviruses.

Zika's surface protein — the primary target of antibodies — looks extremely similar to those on dengue and West Nile virus, members of the same flavivirus family.