Sentences with phrase «subgroup of patients»

We also apply these techniques to model systems in order to identify subgroups of patients who are uniquely sensitive or resistant to targeted therapies, such as poly (ADP - ribose) polymerase (PARP) inhibitors or immune checkpoint blockade.

This imaging approach could also, in the future, help better define which patients with autoimmunity will likely progress to diabetes and classify subgroups of patients who might benefit from different therapeutic strategies.

Further research should be directed toward identifying coping styles of subgroups of patients at risk for poor adaptation and exploring possible protective factors in order to optimize metabolic control and quality of life.

«New schizophrenia treatments may be effective for subgroup of patients.»

The authors of the current study hypothesize that these previous trials may have inadvertently selected subjects who would be nonresponsive to the medication and conclude that future efficacy trials may require the identification of subgroups of patient populations.

Main Outcomes and Measures Revision surgery after an index septorhinoplasty was the main outcome measure, and the rate of revision was calculated within subgroups of patients based on different demographic and clinical characteristics.

Revision surgery after an index septorhinoplasty was the main outcome measure, and the rate of revision was calculated within subgroups of patients based on different demographic and clinical characteristics.

NMDA receptor antibodies are found in a small subgroup of patients with first - episode psychosis, but their clinical relevance is unknown

Many international care guidelines call for further research addressing the different subgroups of patients with lower back pain.

As treatments for HCV have evolved, genotype 3 patients have become the most difficult subgroup of patients to cure.1 Although there have been recent advances in direct - acting antiviral therapies for HCV genotype 1, genotype 3 remains a challenge and is a highly prevalent strain of the infection globally, with a particularly high concentration of cases in Asia.1

Dr. Trivedi, who led the Star * D studies that established widely accepted treatment guidelines for depressed patients, has recently made progress on developing a blood test to determine in advance which antidepressants are more likely to work for important subgroups of patients.

To date, the only known disease related to gadolinium injections is nephrogenic systemic fibrosis, a condition only occurring in a tiny subgroup of patients with renal failure.

«We're definitely encouraged by these results, but we need to optimize the length of treatments, identify which subgroups of patients may benefit most, and determine if this approach works in patients who have nonsomatic forms of the condition that can't be modulated by head and neck maneuvers,» Shore said.

«Our study is small, retrospective and all of the patients were located at a single medical center, but it demonstrates that it's possible to use molecular diagnostics to identify subgroups of patients more likely to respond to a given treatment,» said co-first author John Paul Shen, MD, senior clinical fellow and postdoctoral fellow.

«The benefit we saw was remarkably consistent across the individual components of the endpoint and in all the major subgroups of patients,» said Marc S. Sabatine, M.D., M.P.H., chair of the TIMI Study Group, a senior physician in the Cardiovascular Division at Brigham and Women's Hospital and Harvard Medical School in Boston, and the study's principal investigator.

The finding that one in four patients had weight gain suggests that particular subgroups of patients treated for Q fever are vulnerable to weight gain.

Where research uncovers possible mechanisms for disease, those working in drug discovery can use these data to develop novel diagnostic or monitoring tools, to develop therapies that address the biological pathways concerned, or to develop companion diagnostics to ensure that new — or existing — therapies are targeted at the correct subgroup of patients.

There were similar results across prespecified subgroups of patients including analyses of PD - L1 expression, which showed hazard ratios in favor of nivolumab.

It was small, and the findings can't be applied to certain subgroups of patients who were excluded from the study (such as those with severe depression who may be suicidal), to primary care settings, to forms of dementia other than Alzheimer's, or to other types of antidepressants.

An ideal study would also look at subgroups of patients swallowing their medication orally vs. sublingually who drink coffee at the time of their medication, take iron supplements at the time they take their medication, take calcium supplements at the same time, and eat at the same time as their medication.

The study was developed as an extension of the GAIT (Glucosamine / Chondroitin Arthritis Intervention Trial) study, which showed that the combination of glucosamine hydrochloride (1,500 mg / day) and chondroitin sulfate (1,200 mg / day) was effective in a moderate to severe subgroup of patients.

The Greek UCLA loneliness Scale discriminated well between subgroups of patients regarding the illness duration.

Prevalence, assessment and diagnosis: NMDA receptor antibodies are found in a small subgroup of patients with first - episode psychosis, but their clinical relevance is unknown

The pharmaceutical industry will have to shift from a business model that emphasizes blockbuster drugs to one producing many specialized medications for subgroups of patients.

The large size and diverse racial / ethnic makeup of the Breast Cancer Family Registry allowed the researchers to evaluate mortality risk across different subtypes of breast cancer and subgroups of patients, and adjust for confounding factors.

The current study analysed outcomes in the subgroup of patients with EGFR expressing tumours compared to those with no EGFRs.

We can not make robust conclusions because the subgroup of patients with negative EGFR was very small, but the hypothesis generated here is that those tumours do not respond well to necitumumab.»

In addition, the subgroup of patients with unmethylated MGMT promoter and HLA - A2 appear to particularly benefit,» said Patrick Y. Wen, MD, director of the Center for Neuro - Oncology at Dana - Farber Cancer Institute and professor of Neurology, Harvard Medical School, who will present the data at the conference.

One of the most exciting recent advances in clinical cancer research was the discovery that this subgroup of patients respond — sometimes dramatically — to a new class of drugs targeting the MAPK pathway through which BRAF signals.

A subgroup of patients with NAFLD progresses to the inflammatory subtype of the disease called non-alcoholic steatohepatitis (NASH).

«Our findings contribute further understanding of the biology of psychiatric and neurological diseases and whether autoantibodies detected in a subgroup of patients can trigger psychiatric disorders.

He added: «The only positive and continuous result was in the subgroup of patients who took more exercise, which means regular exercise at least twice a week, plus the wine consumption.

This could help identify a subgroup of patients with similar cell features and match them to the appropriate therapy.

«Detection of ctDNA allows identification of a subgroup of patients at high risk of early relapse and inferior survival, allowing stratification of patients to adjuvant regimens associated with higher toxicity but greater potential for efficacy.»

Antifibroblast growth factor receptor 3 antibodies identify a subgroup of patients with sensory neuropathy.

This could help identify a subgroup of patients with similar cell features and match them to the appropriate therapy, Finkbeiner suggests.

Intensive blood pressure (BP) control reduced the risk of cardiovascular (CV) events by 21 % compared with standard BP control in a subgroup of patients from the ACCORD - BP trial who had type 2...

The combination did not show any deterioration in health - related QoL compared to either treatment alone, even in the subgroup of patients experiencing grade 3/4 adverse events.»

For this subgroup of patients, a promising new treatment called Fecal Microbiota Transplantation (FMT) brings hope.

Now researchers at SciLifeLab, together with international colleagues, have discovered a new correlation between specific molecular features of the disease and subgroups of patients with different prognosis.

«Given the excellent outcome, it will be important to determine if treatment can be further reduced in this subgroup of patients,» Pui said.

The investigators also looked at a subgroup of patients with familial hypercholesterolemia, a genetic disorder that causes extremely high cholesterol that increases the risk of early heart disease.

Thus, histamine intolerance seems to be acquired mostly through the impairment of DAO activity caused by gastrointestinal diseases or through the inhibition of DAO, but the high interindividual variations in the expression of DAO in the gut and the association of SNPs in the DAO gene with gastrointestinal diseases provide evidence for a genetic predisposition in a subgroup of patients with histamine intolerance (27).