It was small, and the findings can't be applied to certain
subgroups of patients who were excluded from the study (such as those with severe depression who may be suicidal), to primary care settings, to forms of dementia other than Alzheimer's, or to other types of antidepressants.
We also apply these techniques to model systems in order to identify
subgroups of patients who are uniquely sensitive or resistant to targeted therapies, such as poly (ADP - ribose) polymerase (PARP) inhibitors or immune checkpoint blockade.
This imaging approach could also, in the future, help better define which patients with autoimmunity will likely progress to diabetes and classify
subgroups of patients who might benefit from different therapeutic strategies.
He added: «The only positive and continuous result was in
the subgroup of patients who took more exercise, which means regular exercise at least twice a week, plus the wine consumption.
Not exact matches
«Among the
subgroup of vaccinated
patients who chose to have chemo later, we are seeing 40 percent survival at two years and 20 percent survival at three years,» says Black.
In terms
of cognitive disability, the researchers found that in the
subgroup of MS
patients who underwent neuropsychological testing, those with more cerebral microbleeds had higher disability on verbal and other cognitive function tests.
In addition, the
subgroup of patients with unmethylated MGMT promoter and HLA - A2 appear to particularly benefit,» said Patrick Y. Wen, MD, director
of the Center for Neuro - Oncology at Dana - Farber Cancer Institute and professor
of Neurology, Harvard Medical School,
who will present the data at the conference.
«We're definitely encouraged by these results, but we need to optimize the length
of treatments, identify which
subgroups of patients may benefit most, and determine if this approach works in
patients who have nonsomatic forms
of the condition that can't be modulated by head and neck maneuvers,» Shore said.
However, a pre-specified examination
of the study's secondary endpoints, which included the rate
of heart attacks, revealed that
patients who received the methylprednisolone faced a 15 percent greater risk
of death or heart attack and a 21 percent greater risk
of heart attack alone, a pattern that was consistent across all
subgroups.
The authors
of the current study hypothesize that these previous trials may have inadvertently selected subjects
who would be nonresponsive to the medication and conclude that future efficacy trials may require the identification
of subgroups of patient populations.
Our primary aim is to identify
subgroups of rNB
patients who have potentially targetable genetic (ALK, MAPK pathway, Metabolic - related genes) and / or immunologic (tumor - associated macrophage infiltration and / or programmed death ligand [PD - L1] expression) biomarkers in rNB.
Intensive blood pressure (BP) control reduced the risk
of cardiovascular (CV) events by 21 % compared with standard BP control in a
subgroup of patients from the ACCORD - BP trial
who had type 2...
Lin, Y. S., Lin, L. C., and Lin, S. W. Effects
of zinc supplementation on the survival
of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow - up
of a double - blind randomized study with
subgroup analysis.