Sentences with phrase «suboptimal responses»

For most available T cell immunotherapies, T cells (which play a central role in defending the body against illness) are engineered to recognize and eliminate tumors, but their activity is not specifically controlled, leading to toxicity and unwanted side effects in patients as a result of inflammation or in some cases suboptimal response to treatment.

A suboptimal response to enzyme supplementation usually reflects associated small intestinal disease or bacterial overgrowth.

Not exact matches

We have demonstrated that under suboptimal IVC conditions, there is an adaptive response of the preimplantation embryo that activates physiological mechanisms of developmental plasticity to stabilize conceptus growth and extraembryonic lineage and enhance postnatal fitness that may lead to adult excess growth and cardiovascular, behavioral, and fertility alterations [2].

Interestingly, several of the dogs which failed to respond to thyroid replacement or in which response was suboptimal have subsequently been treated with selective serotonin reuptake inhibitors or tricyclic antidepressants either without or with limited success.

It is hypothesized that suboptimal caregiving environments lead to both abnormal stress response and conduct disorders.