Sentences with phrase «subsequent activation of»

Despite the well - established significance of strand - specific nicking in MMR, the mechanism (s) by which MutS and MutL assemble on mismatch DNA to allow the subsequent activation of MutL's endonuclease activity by β - clamp / PCNA remains elusive.

Her lab explores the relationship between the aging of neural circuits, the accumulation of toxic proteins and the subsequent activation of a chronic inflammatory response.

[5,7,9] Flavopiridol also inhibits cdk7 / cyclin H, thus preventing the phosphorylation and subsequent activation of several cdks [6,8] and down - regulates cyclin D1, the cyclin associated with cdks 4 and 6.

Not exact matches

Only Israel comes even close to this level of military activation of its population, even though many countries have, or had until recently, some form of mandatory military service and subsequent mandatory paramilitary or reserve service, and I am not aware of any national or insurgent military force in the world with a higher percentage of women serving than North Korea (about 33 % of soldiers in enlisted ranks and 50 % of officers in the Israeli Defense Force, which would be the runner up to North Korea, are women).

Subsequent RNA sequencing suggested that digoxin inhibits HIV - 1 gene expression as well as the activation and metabolism of CD4 + T cells.

Trinuclear copper - oxo clusters were identified that exhibit a high reactivity towards activation of carbon - hydrogen bonds in methane and its subsequent transformation to methanol.

The cause of the subsequent seizures appeared to be phospholipase C (gamma) 1, an enzyme spurred into action by TrkB activation.

The data show that the order and type of administration (oral spray or injection) of the vaccines may affect the activation of the immune system and may have a long lasting effect that affects subsequent immunizations as well as the susceptibility to infection.

This decreased reward response to alcohol arose via two mechanisms: an initial activation of stress hormone receptors and a subsequent increase in inhibitory signaling in the brain.

Trinuclear copper - oxo clusters were identified that exhibit a high reactivity towards activation of carbon — hydrogen bonds in methane and its subsequent transformation to methanol.

DGKζ, a lipid kinase, phosphorylates the second messenger DAG, terminating DAG - mediated activation of RasGRP1 and PKC - θ, whereas Cbl - b, an E3 ubiquitin ligase, facilitates ubiquitination and subsequent degradation of the p85 subunit of PI (3) K. Previous studies have evaluated numerous aspects of T cell biology in the two models (16 — 18, 25, 38), but the signaling and functional effects of DKGζ deficiency and Cbl - b deficiency in T cells had not been directly compared.

If a circuit reinforces behavior (activation of the circuit promotes subsequent, repeated activation), this is an approximation of reward or the sense of pleasure that the animal perceives through taking a drug.

In some people, these activation and feedback mechanisms fail, altering the first increase in profusion and subsequent normalization of blood to the heart and brain.

They noted changes in bacterial colonization in the offspring and hypothesize that these changes are responsible for immune activation that leads to subsequent development of autoimmune diabetes.

An acute bout of self - myofascial release increases range of motion without a subsequent decrease in muscle activation or force.

Peters et al. (2014) found no effects of partial sleep deprivation on subsequent conditioning - related brain activation.

Decreased mTORC1 activation and subsequent decreases in muscle protein synthesis, coupled with increased FOXO nuclear localization, increased transcription of atrophy - related genes, with up - regulated caspase 3 activation and muscle protein ubiquitylation provide a possible mechanism contributing to skeletal muscle loss in response to periods of negative energy balance.

Any employee who, on or after an optional retirement program's activation, becomes eligible to participate in the program by reason of a change in status due to the subsequent designation of the employee's position as one of those referenced in subsection (2), or due to the employee's appointment, promotion, transfer, or reclassification to a position referenced in subsection (2), must be notified by the college of the employee's eligibility to participate in the optional retirement program in lieu of participation in the Florida Retirement System.

Aerosol collections on the NOAA Ron Brown for subsequent processing of INP activation temperature spectra and composition analyses, add a valuable measurement to the ACAPEX and related CalWater2 (NOAA) studies for use in parameterizing and modeling the impacts of marine boundary layer and other aerosols on climate and radiation via aerosol - indirect effects on mixed phase clouds.

Bitcoin News today sees the Bitcoin price rise above $ 3400 in the wake of SegWit activation on 1 August 2017, and the subsequent birth of Bitcoin Cash.

This, along with the higher activation seen before the presentation of emotional facial stimuli, implies that cues related to a secure figure can capture the attention resources, thereby affecting the performance in subsequent cognitive tasks.