Sentences with phrase «subsequent outcomes for»

Not exact matches

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

Such risks and uncertainties include, but are not limited to: our ability to achieve our financial, strategic and operational plans or initiatives; our ability to predict and manage medical costs and price effectively and develop and maintain good relationships with physicians, hospitals and other health care providers; the impact of modifications to our operations and processes; our ability to identify potential strategic acquisitions or transactions and realize the expected benefits of such transactions, including with respect to the Merger; the substantial level of government regulation over our business and the potential effects of new laws or regulations or changes in existing laws or regulations; the outcome of litigation, regulatory audits, investigations, actions and / or guaranty fund assessments; uncertainties surrounding participation in government - sponsored programs such as Medicare; the effectiveness and security of our information technology and other business systems; unfavorable industry, economic or political conditions, including foreign currency movements; acts of war, terrorism, natural disasters or pandemics; our ability to obtain shareholder or regulatory approvals required for the Merger or the requirement to accept conditions that could reduce the anticipated benefits of the Merger as a condition to obtaining regulatory approvals; a longer time than anticipated to consummate the proposed Merger; problems regarding the successful integration of the businesses of Express Scripts and Cigna; unexpected costs regarding the proposed Merger; diversion of management's attention from ongoing business operations and opportunities during the pendency of the Merger; potential litigation associated with the proposed Merger; the ability to retain key personnel; the availability of financing, including relating to the proposed Merger; effects on the businesses as a result of uncertainty surrounding the proposed Merger; as well as more specific risks and uncertainties discussed in our most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.cigna.com as well as on Express Scripts» most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.express-scripts.com.

Actual results may vary materially from those expressed or implied by forward - looking statements based on a number of factors, including, without limitation: (1) risks related to the consummation of the Merger, including the risks that (a) the Merger may not be consummated within the anticipated time period, or at all, (b) the parties may fail to obtain shareholder approval of the Merger Agreement, (c) the parties may fail to secure the termination or expiration of any waiting period applicable under the HSR Act, (d) other conditions to the consummation of the Merger under the Merger Agreement may not be satisfied, (e) all or part of Arby's financing may not become available, and (f) the significant limitations on remedies contained in the Merger Agreement may limit or entirely prevent BWW from specifically enforcing Arby's obligations under the Merger Agreement or recovering damages for any breach by Arby's; (2) the effects that any termination of the Merger Agreement may have on BWW or its business, including the risks that (a) BWW's stock price may decline significantly if the Merger is not completed, (b) the Merger Agreement may be terminated in circumstances requiring BWW to pay Arby's a termination fee of $ 74 million, or (c) the circumstances of the termination, including the possible imposition of a 12 - month tail period during which the termination fee could be payable upon certain subsequent transactions, may have a chilling effect on alternatives to the Merger; (3) the effects that the announcement or pendency of the Merger may have on BWW and its business, including the risks that as a result (a) BWW's business, operating results or stock price may suffer, (b) BWW's current plans and operations may be disrupted, (c) BWW's ability to retain or recruit key employees may be adversely affected, (d) BWW's business relationships (including, customers, franchisees and suppliers) may be adversely affected, or (e) BWW's management's or employees» attention may be diverted from other important matters; (4) the effect of limitations that the Merger Agreement places on BWW's ability to operate its business, return capital to shareholders or engage in alternative transactions; (5) the nature, cost and outcome of pending and future litigation and other legal proceedings, including any such proceedings related to the Merger and instituted against BWW and others; (6) the risk that the Merger and related transactions may involve unexpected costs, liabilities or delays; (7) other economic, business, competitive, legal, regulatory, and / or tax factors; and (8) other factors described under the heading «Risk Factors» in Part I, Item 1A of BWW's Annual Report on Form 10 - K for the fiscal year ended December 25, 2016, as updated or supplemented by subsequent reports that BWW has filed or files with the SEC.

Perineal outcomes on first births are critical because the biggest risk factor for needing suturing on subsequent births is a previous episiotomy.

The healthiest outcomes for mothers and second or subsequent babies occur when there is a gap of 2 - 3 years between births and a period of 6 months of no breastfeeding.

If your ob / gyn says you need a c / sec and you refuse b / c you believe s / he is wrong or you refuse b / c you do not want to risk a uterine rupture during a subsequent pregnancy, who then takes full unequivocal responsibility for the present birth's outcome?

Sharing the experience of childbirth and supporting each other in the subsequent infant feeding practices was perceived as the best outcome for the majority of new mothers and fathers.

It is also important to be careful to distinguish between those factors that are confounders, and those that might best be viewed as mediators or explanatory factors involved in accounting for observed associations between breastfeeding exposure and outcome, such as the quality of the subsequent mother - infant relationship.

Since the three main Westminster political parties all endorse the conclusions of Sir Ian Wood's recent review on how to maximise the economic recovery of oil and gas from the UK Continental Shelf (Search for UKCS Maximising Recovery Review Final Report, here), and its tacit underlying fiscal premises (namely that there is a need for a simplified fiscal regime to incentivise investment and drilling activity, as well as to ease the burden upon the new regulator of the upstream sector), it does not take the gift of prophecy to appreciate that the ultimate outcome of this subsequent review on the shape of the UK fiscal regime seems foreordained; namely, a return to the situation that prevailed before the introduction of SC, whereby the only levy on income from oil and gas fields is to be Corporation Income Tax at the standard rate levied on the likes of Starbucks and Amazon.

The outcome of the subsequent referendum in 1979, in which 80 % of the Welsh electorate voted against devolution, was, in his own description, «traumatic» for Prys - Davies.

When subsequent studies found that CellSearch results had no influence on clinical outcomes, though, insurers lost interest in paying for it.

The success of this iteration led to subsequent AL projects on other targeted areas for improvement, including Aboriginal education, formative assessment, the use of technology and the impact of flexible spaces on learning outcomes.

The existence of an orderly learning environment throughout the school — established through positive rather than negative means, whereby there are high levels of teacher consistency about how it is «enforced» and structures in place to ensure that all students are known well by at least one adult in the school — is a fundamental precondition for improved teaching and learning to occur on which the subsequent improvement in student learning outcomes can be based.

Stage theory conceptualizes leadership succession as a process with distinct phases and demands, rather than a singular event.212 Patterns in the process have been identified, and the ways in which each phase of the succession process shapes and influences the outcome of subsequent phases have been described.213 Most stage models predict that it takes at least five to seven years to build relationships of trust that can serve as a foundation for movement to later stages of the succession process — «consolidation and refinement,» in Gabarro «s (1987) terms.

The role of speech pathologists in the early identification of children with language problems which could lead to interventions which might prevent or ameliorate subsequent reading problems was noted, and the LDA submission put the view that more routine collaboration between speech pathologists and educators could improve literacy outcomes for all students.

An important outcome of her dissertation and subsequent research was the development of reliable observation tools for the assessment and fine - grained analysis of changes over time in children's early literacy learning.

The collaborative, cross-departmental evaluation effort utimately yielded greater understanding and buy - in for evaluation findings and identified meaningful outcomes, such as connections between special programming and subsequent visitor engagement and learning.

Recent research indicates that school and district policies that determine when students take particular courses can have important consequences for achievement and subsequent outcomes like advanced course taking.

These process outcomes confirm the practicality of using cow - calf herds as sentinel populations for environmental exposures and support the validity of subsequent research on these animal populations.

We used 3 - way ANOVAs to determine the effects of season, reproductive status (sterilized versus intact), and sex on percentage overlap followed by Tukey HSD test for pairwise comparisons subsequent to significant ANOVA outcomes.

ultimately imo successful implementation of mitigation policies and subsequent compliance depends on it, the rot must be stopped and reversed at some point for a «successful» outcome.

The workshop addressed, through presentations, subsequent question and answer sessions and general discussion, the following issues: the diversity of nationally appropriate mitigation actions (NAMAs); their underlying assumptions; methodologies, sectors and gases covered; the global warming potential value used; the support needed for NAMA implementation; and the estimated mitigation outcomes.

The court was divided on one point: the consequence of their subsequent finding that the secretary of state's direction to Haringey to replace Shoesmith as director of children's services (DCS) was unlawful; this did not affect the outcome for the appellant.

For people that have been injured in a car crash and the probability of a subsequent lawsuit, the outcome of the traffic ticket can be critical.

Paper addresses the legislative history of Bill 187 with its original stated intent (to eliminate deeming); expansion of deeming in the subsequent draft policies by introducing the concept of «under - employment»; recommendations for a policy that complies with past practice, founding principles and current wording of the Act; call for Board research on employment outcomes after retraining.

In that state, a list of every complaint lodged against lawyers, subsequent investigations and the outcome of those probes is only a phone call away for clients, journalists or anyone else who wants to know.

Each main predictor is likely to be correlated with the others, as well as potentially with the outcome of bullying, so that each main predictor also functions as a potential confounder of the other 2 relationships.28 The task of this analysis is to determine whether each predictor constitutes an independent risk factor for subsequent bullying.

The tendency for number of ACEs to predict health - risk behaviors and / or negative health outcomes has been reported in a number of subsequent studies as well, including those with more diverse samples than in the original investigation (e.g., Anderson & Blosnich, 2013; Mersky et al., 2013; Schilling, Aseltine, & Gore, 2007).

Discrete - time survival analysis, with person - year the unit of analysis and a logistic link function, was used to examine associations of temporally primary (based on retrospective age - at - onset reports) mental disorders and subsequent first onset of suicidality.29 Time was modeled as a separate dummy predictor variable for each year of life up to age at interview or age at onset of the outcome, whichever came first.

The study aimed to identify risks of subsequent suicidal behaviour among Northern Territory residents admitted to hospital with diagnoses of suicidal ideation and / or intentional self - harm and to describe the association between patterns of health service usage and these outcomes in order to identify opportunities for improved preventive follow - up care.

The existence of mental health problems is also an added risk factor for developing mental health complications and poor fetal outcomes during a subsequent pregnancy, and can negatively affect the attachment to this child.

The program of prenatal and infancy home visiting by nurses, tested with a primarily white sample, produced a 48 percent treatment - control difference in the overall rates of substantiated rates of child abuse and neglect (irrespective of risk) and an 80 percent difference for families in which the mothers were low - income and unmarried at registration.21 Corresponding rates of child maltreatment were too low to serve as a viable outcome in a subsequent trial of the program in a large sample of urban African - Americans, 20 but program effects on children's health - care encounters for serious injuries and ingestions at child age 2 and reductions in childhood mortality from preventable causes at child age 9 were consistent with the prevention of abuse and neglect.20, 22

We estimated models by using dependent variables previously associated with significant treatment effects in the follow - up study.10, 20 These included life - course outcomes for the mother, such as number of subsequent children, months on welfare, impairments due to substance use, and number of arrests, as well as life - course outcomes for the study children, such as number of runaway episodes and number of arrests or convictions.

Although the existing research suggests diverse outcomes, scholars have documented that young children exposed to trauma (for example, maltreatment and other forms of violence) are more likely than children who have not been exposed to trauma to experience physiologic changes at the neurotransmitter and hormonal levels (and perhaps even at the level of brain structure) that render them susceptible to heightened arousal and an incapacity to adapt emotions to an appropriate level.21 This emotional state increases their sensitivity to subsequent experiences of trauma and impairs their capacity to focus, remember, learn, and engage in self - control.22

Previous studies suggested that early childhood trauma can lead to an array of negative health outcomes and behaviors, including substance abuse, among both adolescents and adults.22 — 25 For example, childhood physical and sexual abuse has been shown to be associated with illegal drug use.26 — 28 Although these studies provide evidence that most substance abusers come from abusive homes, many of these studies have taken a «categorical» approach to examine the relationship between 1 or 2 forms of these childhood exposures and subsequent drug abuse; few studies have examined illicit drug use and abuse in relation to multiple disturbing or stressful childhood exposures.

JPC = Better Outcomes for kids: While JPC may not be a panacea, JPC is indeed associated with better outcomes for children than SPC, even when their parents do not initially both agree to the parenting plan and even when the conflict at the time of separation or in subsequent years is Outcomes for kids: While JPC may not be a panacea, JPC is indeed associated with better outcomes for children than SPC, even when their parents do not initially both agree to the parenting plan and even when the conflict at the time of separation or in subsequent years is outcomes for children than SPC, even when their parents do not initially both agree to the parenting plan and even when the conflict at the time of separation or in subsequent years is not low.

Her recent work includes an NICHD - funded project (with Kristi Williams at The Ohio State University) that examines the consequences of nonmarital and early fertility for the health of women and their offspring and considers the role that subsequent marriage plays in shaping these outcomes.

Aboriginal Australians experience multiple social and health disadvantages from the prenatal period onwards.1 Infant2 and child3 mortality rates are higher among Aboriginal children, as are well - established influences on poor health, cognitive and education outcomes, 4 — 6 including premature birth and low birth weight, 7 — 9 being born to teenage mothers7 and socioeconomic disadvantage.1, 8 Addressing Aboriginal early life disadvantage is of particular importance because of the high birth rate among Aboriginal people10 and subsequent young age structure of the Aboriginal population.11 Recent population estimates suggest that children under 10 years of age account for almost a quarter of the Aboriginal population compared with only 12 % of the non-Aboriginal population of Australia.11

More research on the reasons for moving house, and subsequent family outcomes, would be useful to inform the implementation of Scottish Government's strategy and action plan for housing (Scottish Government, 2011).

For these reasons, research is bound to be difficult and unsatisfying when it attempts to gage how the timing of a mother returning to work after birth contributes (per se) to children's subsequent developmental outcomes.

Previous MCS studies have related broad composite measures of father engagement in caring activities to subsequent child behavioural outcomes using subscales of total difficulties (emotion, conduct, attention or peer problems)[38 — 40]: most effects were very small and not statistically significant, but (among the large number of analyses performed), inverse associations were reported for (a) engagement at 9 months with emotional problems at 3 years [38], (b) engagement at 3 years with attention problems at 5 years [39] and (c) engagement at 5 years with peer problems at 7 years [40].

Whereas findings have been relatively consistent in documenting the prospective relationships between peer rejection and subsequent maladjustment, results have been mixed for the effects of friendship on these outcomes.