Sentences with phrase «subsequent rates of»

As muscle damaging exercise has previously been reported to decrease GLUT4 translocation and subsequent rates of muscle glycogen resynthesis [49], the possibility that it also may impart a negative effect on protein transporters and rates of protein synthesis can not be discounted.

In a Stony Brook University - led study that uses website - based experiments to uncover whether the age - old adage that «success breeds success» is a reality, researchers found that early success bestowed on individuals produced significant increases in subsequent rates of success, in comparison to non-recipients of success.

The model seems to successfully predict when the next day of fatal attacks might arise just based on the time between the first two attacks and the subsequent rate of escalation.

After 4.6 years, no difference was seen between the two groups in their subsequent rate of heart attacks or strokes.

Similar recent experiments have demonstrated, for example, that briefly holding a warm beverage buoys subsequent ratings of another's personality, that social isolation sensitizes a person to all things chilly, that inappropriate social mimicry creates a sense of cold, and that differences in the setting of the experimental lab's thermostat leads test subjects to construe social relationships differently.

Advertising has no influence on the books we accept for review and the subsequent rating of those books.

That imbalance of eagerness between buyers and sellers has clearly affected prices of risky assets, but it does not generate new cash flows - it simply raises the valuation that the market places on existing streams of future cash flows, and thereby lowers the subsequent rate of return on holding those securities.

Not exact matches

The bond purchases, the third round of quantitative easing embarked upon by the Fed in the wake of the 2008 financial collapse and subsequent recession, have kept interest rates and bond yields low.

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

With unemployment falling steadily through the year, there has been less justification for crisis - era policy, and a sense among policymakers that they could balance the higher rates sought by «hawks» with a slow pace of subsequent increases.

Most analysts expect the first rate hike to come in September of this year, but that the pace of subsequent rate hikes will be slow, taking into account continued middling economic growth and below - target inflation.

The report focused on how local unemployment rates changed between subsequent Februarys, based on data from the Bureau of Labor Statistics.

Timmer: Yeah, so last August which was a key inflection point for the market — because at that point, nobody was expecting tax cuts anymore and the 10 - year Treasury had fallen to 2 %, and the bond market which of course is always pricing in the potential future, was pricing in only one more rate hike over the subsequent two years.

And it doesn't take a genius to recognize that a prolonged period of low interest rates can lead to a build - up of vulnerabilities which could derail an expansion and deepen a subsequent recession.

Earlier this year, top venture capitalist Bill Gurley sounded the alarmon the «unique circumstances» start - up CEOs find themselves in caused by «the pressures of lofty paper valuations, massive burn rates (and the subsequent need for more cash), and unprecedented low levels of IPOs and M&A».

«The pressures of lofty paper valuations, massive burn rates (and the subsequent need for more cash), and unprecedented low levels of IPOs and M&A, have created a complex and unique circumstance which many Unicorn CEOs and investors are ill - prepared to navigate,» Gurley said.

Among the factors that could cause actual results to differ materially are the following: (1) worldwide economic, political, and capital markets conditions and other factors beyond the Company's control, including natural and other disasters or climate change affecting the operations of the Company or its customers and suppliers; (2) the Company's credit ratings and its cost of capital; (3) competitive conditions and customer preferences; (4) foreign currency exchange rates and fluctuations in those rates; (5) the timing and market acceptance of new product offerings; (6) the availability and cost of purchased components, compounds, raw materials and energy (including oil and natural gas and their derivatives) due to shortages, increased demand or supply interruptions (including those caused by natural and other disasters and other events); (7) the impact of acquisitions, strategic alliances, divestitures, and other unusual events resulting from portfolio management actions and other evolving business strategies, and possible organizational restructuring; (8) generating fewer productivity improvements than estimated; (9) unanticipated problems or delays with the phased implementation of a global enterprise resource planning (ERP) system, or security breaches and other disruptions to the Company's information technology infrastructure; (10) financial market risks that may affect the Company's funding obligations under defined benefit pension and postretirement plans; and (11) legal proceedings, including significant developments that could occur in the legal and regulatory proceedings described in the Company's Annual Report on Form 10 - K for the year ended Dec. 31, 2017, and any subsequent quarterly reports on Form 10 - Q (the «Reports»).

Conference Board officials speculated the drop may be a consequence of the debt - ceiling debate and the subsequent downgrade of America's credit rating by Standard & Poor's.

Trudeau's Liberal Party under a former leader swept to power in 1993 and won three subsequent elections — all of them while interest rates were stable or falling and the economy was relatively strong.

Fed officials have variously described the subsequent pace of rate hikes as «gradual,» «shallow,» «slow,» «halting» and even «crawling,» noted economists at Goldman Sachs.

Financial stability risks have become topical in the wake of the global financial crisis and the subsequent extended period of very low interest rates.

The pressures of lofty paper valuations, massive burn rates (and the subsequent need for more cash), and unprecedented low levels of IPOs and M&A, have created a complex and unique circumstance that many Unicorn CEOs and investors are ill - prepared to navigate.

The subsequent cut in benchmark interest rates from 6 % to a record low of 4.85 % suggests policymakers think the slowdown has been too rapid.

Moderate interest rates were associated with a whole range of subsequent returns over the following decade, and we know that those outcomes were 90 % correlated with the level of valuations at the beginning of those periods (on reliable measures such as market cap / GDP, price / revenue, Tobin's Q, the margin - adjusted Shiller P / E, and others we've presented over time - see Ockham's Razor and the Market Cycle).

As a result there was actually a relatively low rate of client redemptions, especially relative to the tech bubble of 2000, and importantly, clients participated in the subsequent increase in the value of their investment portfolios by staying invested as markets recovered.

The periods where tax cuts were credited for producing strong economic growth were periods where the unemployment rate was high and population growth was relatively strong, providing a great deal of slack for subsequent employment growth.

So investors might have believed that the extraordinarily depressed market valuations of 1974 and 1982 were «justified» by recession and high interest rates, but that did nothing to prevent the S&P 500 from enjoying remarkably high returns in subsequent years.

It shows someone who retired in the mid-1990s could expect to receive a 10 percent rate of return on their Canada Pension Plan contributions, but late boomers, Gen - Xers and subsequent generations can expect a rate of return closer to 2 percent.

For provisional ratings, this announcement provides certain regulatory disclosures in relation to the provisional rating assigned, and in relation to a definitive rating that may be assigned subsequent to the final issuance of the debt, in each case where the transaction structure and terms have not changed prior to the assignment of the definitive rating in a manner that would have affected the rating.

Following the two increases in the cash rate at the end of 2003, the Board considered at its subsequent monthly meetings whether there was a case to increase rates further.

In previous work I drew attention to the link between the rapid growth of interest rate derivatives [IRDs] at Chase and Morgan subsequent to an unprecedented gold market preemptive selling episode in 1996.

While the report does say that higher mortgage rates could cool things off later this year or early next year, it adds that «a flood of foreclosures, and subsequent sharp supply increases, is simply not in the cards.»

«Although extensive choice seems appealing, research shows that it may hinder motivation to buy and decrease subsequent satisfaction with purchased goods... Using data from nearly 800,000 employees, we tested the hypothesis that employee 401 (k) participation rates fall as the number of fund options increase.

It concluded that negative intermeeting stock market returns are a stronger predictor of subsequent target changes in the Fed funds rate than any commonly followed macroeconomic variable.

Indeed, because the level of interest rates at any point in time is highly correlated with the level of nominal economic growth over the preceding decade, the relationship between starting valuations and actual subsequent S&P 500 nominal total returns is nearly independent of interest rates.

The annualized growth rate of the FHFA price index has been volatile month to month but provides a detailed measure of the pre-boom stability, boom period acceleration, subsequent collapse and recovery of prices.

Conversion rate jargon aside, finding the right PPC platform for you is no doubt one of the most important factors of paid advertising planning and subsequent success.

On June 28, 2012, subsequent to the end of the second quarter, the company completed its first securitization of vacation ownership notes receivable as an independent public company securitizing $ 250 million of notes at a weighted average interest rate of 2.625 percent and a 95 percent advance rate.

Within the context of this broad strategic assessment, the Board judged at the time of the June meeting that the case for an easing was not sufficiently strong and, in the event, subsequent developments tended to weaken that case further, so that the cash rate was again held unchanged at the July and August meetings.

In the six months ended March 31, 2018, as a result of the U.S. Tax Cuts and Jobs Act, Post recorded a $ 265.3 million one - time income tax net benefit which included (i) a $ 272.4 million benefit related to an estimate of the remeasurement of Post's existing deferred tax assets and liabilities considering both the expected fiscal year 2018 blended U.S. federal income corporate tax rate of approximately 24.5 % and a 21 % rate for subsequent fiscal years and (ii) a $ 7.1 million expense related to an estimate of the transition tax on unrepatriated foreign earnings.

On June 28, 2012, subsequent to the end of the second quarter, the company completed its first securitization of vacation ownership loans as an independent public company, securitizing $ 250 million of vacation ownership notes receivable at a weighted average interest rate of 2.625 percent and an advance rate of 95 percent.

The convertible note discount rate allows investors to convert the amount of their loan, plus accrued interest, into equity at a reduced price relative to the investors in that subsequent round.

In this segment of the «Look Back» series, we consider inflation and the subsequent real rates of return of holding cash (defined as holding Treasury bills or T - bills) over the past century.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

Epidemiologists have found that when the incarceration rate rises in a county, there tends to be a subsequent increase in the rates of sexually transmitted diseases and teenage pregnancy, possibly because women have less power to require their partners to practice protected sex or remain monogamous.

This view, at any rate, is the only one compatible with saying, as Whitehead does say, that an entity which is actual, is actual regardless of whether its present existence is that of a subject enjoying the universe from which it arises or that of a superject functioning objectively in subsequent processes.

My view is that that metaphysics can explain all, or, at any rate, almost all, of Merleau - Ponty's subsequent reflections on the flesh.

Even today, Flint has the fourth - highest murder rate in the country, but in recent years, Flint's been infamous for a different kind of headline: the water crisis, and the government's subsequent attempt to cover it up («Everybody has been affected by it,» Crews says.).

These audience figures are widely used by broadcasters and advertisers for the determination of a program's popularity and subsequent advertising rates.

This will reduce the rates of disintermediation and subsequent fraud.