Sentences with phrase «subsequent reduction of»

In essence, UCS recommends the same charger to be used for all future handsets, regardless of make and model, yielding a 50 percent reduction in standby energy consumption, elimination of 51,000 tons of redundant chargers, and a subsequent reduction of 13.6 million tons in greenhouse gas emissions each year (source: the website of International Telecommunication Union).

This requires an integrated global framework, capable of being implemented at national and project levels, which would enable the quantification and subsequent reduction of humanity's impact on biodiversity.

Consistent with this, WDR26 loss - of - function single - nucleotide mutations identified in these subjects lead to nonsense - mediated decay with subsequent reduction of RNA expression and protein levels.

The cessation of nuclear testing and of the development of new weapons systems, and the subsequent reduction of existing stockpiles of weapons would stabilize the international balance of terror.

Not exact matches

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

Those tariff reductions (and subsequent Canadian employment declines) happen regardless of whether or not Canada is a signatory to TPP, which is significant given that only a small percentage of Canadian assembled vehicles are for domestic consumption.

Second, he directly relates turnover and volatility reduction for an equally weighted portfolio that: (1) initially selects the 500 of 3,000 liquid global stocks with the lowest weekly volatility over the prior three years; and, (2) each subsequent month rebalances stocks that have at least doubled their baseline portfolio weight and sells stocks when they fall out of the top X % of the volatility ranking, with X varying from 20 % (baseline) to 90 %.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

China has observed declining population growth for over a decade as a result of the one - child policy and a therefore subsequent reduction in household size.

The program of prenatal and infancy home visiting by nurses described above produced treatment - control differences in 15 - year - olds» arrests and reductions in arrests and convictions among 19 - year - old females.32, 33 In a subsequent trial with a large sample of urban African - Americans the program produced treatment impacts on 12 - year - olds» use of substances and internalizing disorders.34

Ensuring that actions to improve infant feeding are included in all of these relevant policy areas, including obesity, diabetes and cancer reduction, emotional attachment and subsequent school readiness, improved maternal and child mental health and environmental sustainability

The 2005 study by Harder and colleagues (also mentioned in the comments section) looked at risk of obesity but didn't find a reduced risk associated with breastfeeding beyond 9 months: «From 1 month of breastfeeding onward, the risk of subsequent overweight continuously decreased up to a reduction of more than 30 percent, reaching a plateau at 9 months of breastfeeding.»

It was US $ 40 under the original deal but we have negotiated it down to US $ 32... the capacity charge whether they produce electricity or not... under the old deal it was 6.275 cents, under the new one which they had already signed we have negotiated it downwards to 5.095 which is a reduction of over 20 percent and then the subsequent 10 years that we have given them I goes down to 4.0».

The fourth option is a reduction of the fee and a making good of the subsequent shortfall to universities.

Aides to County Executive Edward Mangano blame the increase on superstorm Sandy and a subsequent two - month extension of the protest period, though critics say Mangano encourages protests by granting too many assessment reductions.

The sooner global emissions start to fall, the lower the risk not only of major climatic disruption, but also of the economic disruption that could otherwise arise from the need for subsequent reductions at historically unprecedented rates, should near - term action remain inadequate.»

DeLaune said previous field studies from the Rolling Plains and adjacent High Plains demonstrated mixed results, with some showing a reduction in soil moisture and cash crop yield due to cover crops and others indicating no significant impact of cover crops on subsequent fiber yield.

In their approach, they discovered that germanium nanowires are grown by the reduction of germanium oxide particles and subsequent self - catalytic growth during the thermal decomposition of natural gas, and simultaneously, carbon sheath layers are uniformly coated on the nanowire surface.

Normally a total gastrectomy (removal of the stomach) is employed in these cases, with a subsequent dramatic reduction in the quality of life for patients.

Moreover, achieving normal glucose levels — even briefly during the trials — was associated with a substantial reduction in subsequent development of type 2 diabetes.

They are conventionally prepared by repetitions of the stoichiometric reactions using phosphorus reagents and subsequent reduction and partial oxidation.

The subsequent pharmacophore approaches used for further molecular - size reduction led to the identification of cyclic pentapeptides containing these indispensable amino acids.

Subsequent phases will focus on establishing the doses required for efficacy, or reduction or elimination of insulin use.

Certain particle compounds may directly generate ROS in vivo because of their surface chemistry (eg, metals, organic compounds, and semiquinones) or after bioactivation by cytochrome P450 systems (eg, polycyclic aromatic hydrocarbon conversion to quinones).6, 290 a, 290 b A particle surface or anions present on otherwise more inert particles may disrupt iron homeostasis in the lung and thereby also generate ROS via Fenton reactions.291 Other PM constituents may do so indirectly by the upregulation of endogenous cellular sources (eg, nicotinamide adenine dinucleotide phosphate [NADPH]-RRB- oxidase) 292,293 or by perturbing organelle function (eg, mitochondria) by taken - up PM components.261 Particle stimulation of irritant and afferent ANS fibers may also play a role in local and systemic oxidative stress formation.294 Given the rich antioxidant defenses in the lung fluid, secondarily generated oxidization products of endogenous molecules (eg, oxidized phospholipids, proteins) or a reduction in endogenous antioxidants per se may be responsible at least in part for the state of oxidative stress in the lungs (along with instigating the subsequent cellular responses) rather than ROS derived directly from PM and its constituents.

This study showed that subsequent to 3 months of consumption, chronic fibromyalgia patients experienced pain reduction, morning stiffness reduction, sleep improvement, chronic headache improvement, dullness feeling improvement, irritable colon syndrome improvement, memory and cognitive state improvement.

If you don't rest for long enough, your subsequent sprints will be more aerobic in nature than anaerobic, so you won't get the full benefit of maximal testosterone release and man boob reduction.

Furthermore, substituting oxygen for sulfur — causing oxidation — in sulfur - containing amino acids (including in the more rare S - adenosylmethionine) can have effects in methionine residues where the surface is exposed, causing an oxidation - reduction cycle, imparing the activity of «methionine sulfoxide reductase and the subsequent accumulation of methionine sulfoxide residues [that] are associated with age - related diseases, neurodegeneration, and shorter lifespan.»

What can happen then is, technically, your hemoglobin concentration is gonna test, if you're gonna test it is below normal just because you've got this big expansion plasma volume without a subsequent expansion in red blood cell concentration and because red blood cell concentration is kinda synonymous with your hemoglobin levels, all that drops and that's sports - induced anemia and really, it's an adaptation of your cardio - vascular system really the result is that you become a better athlete but you may notice that this reduction in hemoglobin, etc..

Too much weight loss can cause a reduction in muscle mass and subsequent loss of power and stamina.

Exploring multiple sets of the Nordic hamstring curl exercise, Marshall et al. (2015) noted that a single set of 5 repetitions led to substantial reductions in peak eccentric knee flexion moments during the exercise, with even further reductions in subsequent sets, implying that performing the Nordic hamstring curl prior to practice or other exercise might not be advisable.

The reduction of risk becomes even greater with each subsequent pregnancy.

We found an inverse log - linear relationship between coffee consumption and subsequent risk of diabetes such that every additional cup of coffee consumed in a day was associated with a 7 % reduction in the excess risk of diabetes relative risk, 0.93 [95 % confidence interval, 0.91 - 0.95]-RRB- after adjustment for potential confounders.

We charge an origination fee of 2.5 % - 4 % on your first loan, and if you renew you may be eligible for subsequent reductions.

To be effective, management information systems should track the subsequent principal reductions and charge - off history of loans that have been granted an extension, deferral, renewal, or rewrite.

These indicators can include livelihoods restored, improved access to basic health facilities, reduction in mortality rates and loss of life in subsequent emergencies.

Yes, there was the discontinuance of trials associated with Peg - SN38 in May, the subsequent departure of the CEO and his replacement with the CFO and the reduction in staff last Fall.

The decline here is a result of my well - timed & lucrative exit from NTR plc, and a fortunate reduction (in light of the subsequent & highly disappointing cost of insurance update) in my Alternative Asset Opportunities holding.

The zoonotic pathogens of most concern to any facility — whether an animal shelter, veterinary hospital, boarding facility or chicken farm — are scrutinized to determine their kill rates and the subsequent reduction in airborne transmission that are possible when a disinfection system is installed in an existing animal facility.

A subsequent electroretinography study identified an initial reduction of the cone photoreceptor function which led to the condition being re-classified as a cone - rod dystrophy (CRD), rather than a rod - led PRA, and the disease was termed CORD1 for cone - rod degeneration 1 [36].

Since plaque is the initiating cause of gingivitis and subsequent periodontitis, assessment of plaque reduction is a key step in determining the efficacy of canine and feline dental health products and procedures.

Since plaque is the initiating cause of gingivitis and subsequent periodontitis, assessment of plaque reduction is a key step in determining the effi cacy of canine and feline dental health products and procedures.

Sabre's technology aims to help LATAM Airlines Group to deliver a wide range of enhancements in flight planning and operational efficiency, including a subsequent reduction in CO2 emissions.

It was developed in response to a set of conditions whose consequences can no longer be ignored: the reduction of housing to a matter of real estate markets and property relations; the withdrawal of the state and the subsequent dismantling of social housing; the disappearance of alternative housing models; and, finally, a growing systemic break between mainstream architectural practitioners and the individuals and communities for whom they work.

This plan serves as a welcome first step to phase out emissions from the sector, but the IMO must now build on the agreed minimum target of 50 % reductions in subsequent reviews of the strategy to comply with its fair share of emissions under the Paris Agreement.

It addressed, through presentations, subsequent question and answer sessions and a general discussion, the following issues: clarification of the nature and level of the targets communicated by developed country Parties; assumptions and conditions associated with the targets; commonalities and differences of approach in measuring the progress towards the targets; comparability of emission reduction efforts by developed country Parties, and options and ways to increase the level of ambition of the pledges; relevant policies and measures to support the targets, and experience with low - emission development strategies; and possible ways forward.

Defines «reporting entity» to mean: (1) a covered entity; (2) an entity that would be covered if it had emitted, produced, imported, manufactured, or delivered in 2008 or any subsequent year more than the applicable threshold level of carbon dioxide; (3) other entities that EPA determines will help achieve overall goals of reducing global warming pollution; (4) any vehicle fleet with emissions of more than 25,000 tons of carbon dioxide equivalent on an annual basis, if its inclusion will help achieve such reduction; (5) any entity that delivers electricity to a facility in an energy - intensive industrial sector that meets the energy or GHG intensity criteria.

It should be noted here that the prior declaration of a carbon pollution emergency by the President is a key enabling element of an effective GHG reduction strategy, an element which largely insulates the use of CAA Section 108 from subsequent lawsuits.

«The sooner global emissions start to fall, the lower the risk not only of major climate disruption, but also of economic disruption that could otherwise arise from the need for subsequent reductions at historically unprecedented rates, should near - term action remain inadequate,» says another of the report's authors, Michael Grubb, professor of international energy and climate change policy at University College London's Institute of Sustainable Resources.

This is a tragedy because each year when there has been a failure to commit to adequately reduce greenhouse gas (ghg) emissions has made it more difficult in subsequent years to get on a ghg emissions reduction pathway capable of preventing serious climate change.

While much of the subsequent reworking of the model has led to a reduction in these historical influences, some parts of the model still hark back to the days of punch cards, FORTRAN 66 and line printer output.