Sentences with phrase «subset of cancer»

In addition, Chk1 inhibition is highly effective as monotherapy in a subset of cancer cell lines (Thompson and Eastman, Brit J Clin Pharm 2013).

It suggests that at the root of any cancer there is a small subset of cancer cells that are solely responsible for driving the growth and evolution of a patient's cancer.

Some scientists have blamed so - called cancer stem cells, a subset of cancer cells that might be able to remain dormant, evading chemotherapy or radiation treatments, only to form new tumors months or years later.

«We have seen progress in specific subsets of cancer.

Currently, only a fraction of patients respond to immunotherapy, and immunotherapy only works in a subset of cancers.

The method is based on the knowledge that different tumors can be driven by different subsets of cancer genes.

The team, which included members of the Health Science Center departments of medicine and biochemistry, investigators from the UT Southwestern Medical Center at Dallas and a group of collaborators from Austria, found that the gene that codes the enzyme D2 - hydroxyglutarate dehydrogenase (D2HGDH) is mutated in a subset of cancers called diffuse large B - cell lymphomas.

Overall, including all genomic variations present in most if not all tumor cells (clonal) as well as those present only in subsets of the cancer cells (subclonal) from tumor tissue, the researchers detected a total of 864 genetic changes in tissue samples across the three tumor types, and 627 (73 %) of those were also found in the blood.

A new study published in the Oct. 9 issue of the journal Nature Medicine demonstrates, for the first time, that glioblastoma (GBM), the most common and most lethal brain tumor, is driven by two distinct subsets of cancer stem cells.

Modeling mRNA expression heterogeneity in tumors through bimodal profiles is a novel powerful approach with the potential to uncover therapeutic targets that benefit subsets of cancer patients.

It may be more applicable than just the subset of cancers that make this protein... In an ideal world this drug would be preventative.

Not exact matches

Associate professor Mary - Ellen Taplin, of the Dana - Farber Cancer Institute, Boston, USA, will tell the 26th EORTC - NCI - AACR Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, Spain, that galeterone was well tolerated by patients in the ARMOR2 trial, and also lowered PSA levels in a subset of men with CRPC that was resistant to other drugs that target the cancer, such as enzalutamide and abiratCancer Institute, Boston, USA, will tell the 26th EORTC - NCI - AACR Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, Spain, that galeterone was well tolerated by patients in the ARMOR2 trial, and also lowered PSA levels in a subset of men with CRPC that was resistant to other drugs that target the cancer, such as enzalutamide and abiratCancer Therapeutics in Barcelona, Spain, that galeterone was well tolerated by patients in the ARMOR2 trial, and also lowered PSA levels in a subset of men with CRPC that was resistant to other drugs that target the cancer, such as enzalutamide and abiratcancer, such as enzalutamide and abiraterone.

Cancer immunotherapy can produce durable clinical responses, but only in a subset of patients.

In contrast, the cancer cells often had subsets of miRNAs that were not connected to the rest of the network — rogue groups that had broken free.

If hypofractionated radiation with curative intent can reduce the treatment time for lung cancer patients by half with no greater toxicity, and with equivalent — if not better — tumor control and survival outcomes, this research could result in a change in the paradigm of how a large subset of locally advanced NSCLC patients are treated.»

Analyzing data from thousands of cancer lines and tumors, the researchers found that those demonstrating resistance to proteasome inhibitor drugs were marked by suppressed expression of one or more of the cells» proteasome cap subunits (which are a subsets of the larger proteasome).

«Starting with our cell model that mimics human pancreatic cancer progression, we identified released proteins, then tested and validated a subset of these proteins as potential plasma biomarkers of this cancer,» Zaret said.

«There has been a tremendous effort over the past several years to block EGFR as a treatment for lung cancer, but this therapy only works in a small subset of patients.

But she notes that even if the rodent finding is mirrored in people, only a subset of human cancers would be influenced by the drugs — those not already abundant in NRF2.

The finding might lead to new therapies for a subset of patients with glioblastoma, the most common and lethal form of brain cancer.

For the subset of more recent patients, the researchers assessed tumor cell behavior — in particular, cancer cells» ability to cross the endothelium (inner layer) of blood vessels.

Of these variants, reported today in the journals Nature and Nature Genetics, 65 are common variants that predispose to breast cancer and a further seven predispose specifically to oestrogen - receptor negative breast cancer - the subset of cases that do not respond to hormonal therapies, such as the drug tamoxifeOf these variants, reported today in the journals Nature and Nature Genetics, 65 are common variants that predispose to breast cancer and a further seven predispose specifically to oestrogen - receptor negative breast cancer - the subset of cases that do not respond to hormonal therapies, such as the drug tamoxifeof cases that do not respond to hormonal therapies, such as the drug tamoxifen.

A multicenter team of researchers reports that a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that do not affect the DNA sequence itself yet control how it operates confer survival advantages on subsets of pancreatic cancer cells.

Some of the first evidence for cancer stem cells came from studies of leukemia in the 1990s, which showed that only a small subset of the cancerous blood cells could propagate the disease in mice.

The team then selected a subset of data for developing a panel for differentiating between pancreatic cancer and healthy pancreas tissue and thereafter applied this «Pancreatic Cancer Predictor» to the remaining datasets for independent validation to confirm the accuracy of the macancer and healthy pancreas tissue and thereafter applied this «Pancreatic Cancer Predictor» to the remaining datasets for independent validation to confirm the accuracy of the maCancer Predictor» to the remaining datasets for independent validation to confirm the accuracy of the markers.

Now, through this work, we are beginning to understand why some subsets of lung cancer are so invasive.»

Human epidermal growth factor receptor 2 (HER2) is upregulated in a subset of human breast cancers.

«First - line immunotherapy treatment can improve survival for subset of lung cancer patients: Results of phase III global clinical trial show that 75 percent of stage IV lung cancer patients with both complex tumor mutations and PDL - 1 positive status respond to nivolumab.»

This analysis led to the identification of several lncRNAs that are overexpressed in a particular subset of ovarian cancer, those that are thought to be the most aggressive.

Monitoring immune cell activity — including phenotyping immune cell subsets, tracking cell proliferation, and measuring cytokine production — can provide insights into the overall status of immune function in patients, particularly those undergoing immunosuppression after transplants, enduring cancer treatment, or suffering from autoimmune disease or other pathologies that affect the immune system.

In a randomized, phase 2 multi-center clinical study, led by Manisha Shah, MD of The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James), investigators tested the effectiveness of the targeted therapy drug, dabrafenib (pronounced «da bRAF e nib» and marketed as Tafinlar), given alone compared with the same drug given in combination with trametinib (pronounced «tra ME ti nib,» marketed at MeKinist) to treat a subset of advanced papillary thyroid cancer patients with B - raf mutaCancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James), investigators tested the effectiveness of the targeted therapy drug, dabrafenib (pronounced «da bRAF e nib» and marketed as Tafinlar), given alone compared with the same drug given in combination with trametinib (pronounced «tra ME ti nib,» marketed at MeKinist) to treat a subset of advanced papillary thyroid cancer patients with B - raf mutaCancer Hospital and Richard J. Solove Research Institute (OSUCCC — James), investigators tested the effectiveness of the targeted therapy drug, dabrafenib (pronounced «da bRAF e nib» and marketed as Tafinlar), given alone compared with the same drug given in combination with trametinib (pronounced «tra ME ti nib,» marketed at MeKinist) to treat a subset of advanced papillary thyroid cancer patients with B - raf mutacancer patients with B - raf mutations.

These efforts are now turning up evidence that a sizable subset of childhood cancers are rooted in inherited genes, or mutations so soon after conception that they pervade every cell.

A subset of these changes was much more prevalent in lung - cancer patients than cancer - free smokers.

There is a subset of individuals with hyperhidrosis that is caused by other conditions such as medications, cancers, metabolic and hormonal imbalances, infections and nerve injury.

Using genetic tools to establish in which cells cancer - driving mutations originated and then propagated into other cancer cells, they demonstrated that a distinct and rare subset of MDS cells showed all the hallmarks of cancer stem cells, and that no other malignant MDS cells were able to propagate the tumour.

Although it is among the most highly metastatic of all cancers, multiple myeloma is driven to spread by only a subset of the myeloma cells within a patient's body, researchers at Dana - Farber Cancer Institute have found in a study presented at the annual meeting of the American Society of Hematology (ASH).

However, lingering infections with a subset of about 19 «high - risk» HPV types can lead to the development of cervical cancer or other genital / anal cancers.

Earlier this year, Cate and Lee discovered that for a certain specialized subset of mRNAs — most of which have been linked somehow to cancer — initiation is triggered by a different protein in eIF3.

Lee and Cate's research hints that this secret lever, which triggers translation of only a special subset of mRNAs — perhaps only 500 out of some 10,000 mRNAs produced by a cell — will be found to play a critical role in other diseases besides cancer, as well as in plants and animals.

Therapies that prevent tumor blood vessel growth are often used in clinics to fight cancer — but they are only effective in a particular subset of patients.

«We now have a better idea of how NSAID use may benefit a subset of patients diagnosed with colorectal cancer,» said Xinwei Hua, the study's first author and an epidemiologist at Fred Hutch.

He thinks a number of cancer cell subsets are never really affected by most targeted anticancer drugs currently used.

He adds, «This study was actually a pilot project for a much larger effort within the Center for Molecular Therapeutics to map responses against drug combinations across hundreds of cancer cell lines, not just melanoma, and look for novel combinations that will benefit subsets of patients regardless of the particular type of tumor they have.

Cancer biologist Todd Golub at Harvard Medical School in Boston, Massachusetts, and colleagues developed a way to identify small RNAs from more 200 cancer types and found that different types of cancer harbor different subsets of micrCancer biologist Todd Golub at Harvard Medical School in Boston, Massachusetts, and colleagues developed a way to identify small RNAs from more 200 cancer types and found that different types of cancer harbor different subsets of micrcancer types and found that different types of cancer harbor different subsets of micrcancer harbor different subsets of microRNAs.

We have shown that invariant Natural Killer T cells (iNKT), a subset of CD1d - restricted T cells displaying innate effector functions, rewire the prostate cancer microenvironment leading to cancer control.

Thanks to proceeds from the ride, researchers have identified a subset of non-Hodgkin's lymphoma cells that resist standard chemotherapy and can cause cancer to recur.

Queen's researcher Jennifer Flemming, is the first in Canada studying the links between cirrhosis and biliary tract cancer (a rare subset of liver cancer) from both a clinical and population perspective.

«At the moment, Avastin is given to all colon cancer patients but only a subset of patients benefits from it,» John says.

The next step is to determine if phenformin alone would be a sufficient therapy for certain subsets of NSCLC or if the drug would perform better in combination with existing cancer drugs.

The drug is given to a subset of lung cancer patients at a daily dose of 150 mg, but whether this dosing strategy was the best way to prolong survival had not been empirically tested.