Sentences with phrase «subset of genes in»

Although it is important to inform people that scientists are attempting to define this subset of genes in a number of species, «imprintome» is not used in this paper as it was originally intended.

They arise in a unique subset of genes in which, after conception, the DNA in the embryo that came from the mother is expressed differently than the DNA from the father.

Not exact matches

A subset of such genes, known as Hox genes, is found across the animal kingdom, in humans as well as fruit flies.

Using a novel combination of technologies, including trio exome sequencing of patient / parental DNA and genetic studies in the tiny larvae of zebrafish, the EuroEPINOMICS RES consortium found that mutations in the gene CHD2 are responsible for a subset of epilepsy patients with symptoms similar to Dravet syndrome — a severe form of childhood epilepsy that is in many patients resistant to currently available anti-epileptic drugs.

The discovery of CHD2 as the culprit gene in a subset of children with epileptic encephalopathy is a major step for us.»

They found a distinctive subset of genes was active in the nonresponsive bees.

Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.

They have also looked for the activity of similar genes in the silk glands and other tissues of cobweb - weaving spiders, a subset of orb weavers that build 3D webs instead of flat ones.

These efforts are now turning up evidence that a sizable subset of childhood cancers are rooted in inherited genes, or mutations so soon after conception that they pervade every cell.

The team, which included members of the Health Science Center departments of medicine and biochemistry, investigators from the UT Southwestern Medical Center at Dallas and a group of collaborators from Austria, found that the gene that codes the enzyme D2 - hydroxyglutarate dehydrogenase (D2HGDH) is mutated in a subset of cancers called diffuse large B - cell lymphomas.

In order for these unspecialized cells to acquire the characteristics that make a leaf cell different from a root cell or a blood cell different from a muscle cell, they must turn on different subsets of genes to produce the proteins responsible for each cell type's distinctive properties.

In 2007 a French team discovered a disrupted gene called SHANK3 in a small subset of people with autisIn 2007 a French team discovered a disrupted gene called SHANK3 in a small subset of people with autisin a small subset of people with autism.

The groups that evolved into bonobos, chimps, and humans all retained slightly different subsets of this ancestral population's diverse gene pool — and those differences now offer clues today to the size and range of diversity in that ancestral group.

They hope to identify the complete set of DNA binding sites and corresponding target genes for the regulons in embryonic stem cells and a subset of the cells they differentiate into.

The researchers also determined that many of the 18 newly identified autism genes affect the operation of a small subset of biological pathways in the brain.

Normally, the left side of the brain controls the right side of the body and vice versa, but in people with a faulty DCC gene, a subset of the fibers from the brain's motor command center may stay on the same side instead of crossing over.

Dr Peter Rugg - Gunn, group leader in the Babraham Institute's Epigenetics research programme and a senior co-author on the paper, explains: «One of the exciting aspects of this study is that we were able to capture naïve stem cells at a very early stage of their reprogramming — these early cells had switched on a subset of naïve - specific genes, but they had not yet fully matured.

In the cells of humans and other organisms, only a subset of genes are active at any given time, depending largely on the stage of life and the particular duties of the cell.

The study focused on a small subset of nuclear receptors, a large family of proteins that regulate gene expression in response to signals from various binding partners, including steroids and fats.

After removal of similar viral genomes, bootscan plots of the whole genome and individual genes from a subset representing human / simian adenoviruses in species A — G and all non-primate vertebrate adenoviruses were generated.

Second, the AAV preps generally used for gene editing are low titre, and are therefore able to infect only a small subset of the cells used in a given experiment.

The fusion of these two genes was observed in just three percent of tumors studied, so any therapy based on this particular genetic aberration would apply to only a small subset of glioblastoma patients.

These studies have given us a better understanding of the genes that influence the development of these cells, and in particular, to characterize the differences between subsets of Vα14i NKT cells with distinct functional properties.

Carlos worked with postdoc John Abramyan on the CBM18 gene family in Bdto confirm gene expression of the members of the family by RT - PCR before we choose a subset to work on further.

Lipopolysaccharide stimulates the MyD88 - independent pathway and results in activation of IFN - regulatory factor 3 and the expression of a subset of lipopolysaccharide - inducible genes.

«We were surprised to see that expression of the gene TSLP — which encodes a cytokine long known to be involved in epithelial - induced inflammation — was exclusive to a particular subset of tuft cells,» Haber noted.

Our laboratory has assembled a comprehensive set of tools for doing this, including mice with conditional ablation of the Btla gene in different subsets of immune cells.

Not content to provide just the missing evidence for a 60 - year - old puzzle, Wilhelm and his colleagues went on to describe what a subset of these genes do in C. elegans and how they might be driving the ageing process.

Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development.

A subset of ALCL tumors carries chromosomal aberrations involving the anaplastic lymphoma kinase (alk) gene on chromosome 2p23 resulting in ALK overexpression (2).

In their study, the researchers first confirmed that a gene previously associated with telomere length also affected telomeres in a subset of their UK sample of more than 2,700 peoplIn their study, the researchers first confirmed that a gene previously associated with telomere length also affected telomeres in a subset of their UK sample of more than 2,700 peoplin a subset of their UK sample of more than 2,700 people.

Taking a similar tack, Littman's team later uncovered a gene switch called RORgammat, which shapes the development of a subset of helper T cells called Th - 17 cells, which abound in the intestines.

iTeos focuses upon selected key suppressive mechanisms of immunity in cancer based on gene expression, association with immune cell subsets, protein expression in human tumors and biological validation.

In light of this, homology - based methods of functional gene annotation will be suitable for only a subset of the genome.

In small cell lung cancer, starting from bioinformatics analyses of large gene expression datasets, we clustered subsets of co-expressed gene modules, derived networks of transcription factors and simulated their dynamics using logic - based mathematical modeling.

These mutant kinases are attractive therapeutic targets, as demonstrated by the efficacy of imatinib in BCR - ABL — positive chronic myelogenous leukemia (CML), 5 as well as in MPD associated with activating alleles involving PDGFRA or PDGFRB.2, 6,7 In addition, activating mutations in the FLT3 receptor tyrosine kinase are the most common genetic event in acute myeloid leukemia (AML), and specific inhibitors of the FMS - like tyrosine kinase 3 (FLT3) have entered late - stage clinical trials.8 Although mutations in tyrosine kinases and in other genes have been identified in a subset of MPD and AML, in many cases the genetic events that contribute to the molecular pathogenesis of these diseases remain unknowin BCR - ABL — positive chronic myelogenous leukemia (CML), 5 as well as in MPD associated with activating alleles involving PDGFRA or PDGFRB.2, 6,7 In addition, activating mutations in the FLT3 receptor tyrosine kinase are the most common genetic event in acute myeloid leukemia (AML), and specific inhibitors of the FMS - like tyrosine kinase 3 (FLT3) have entered late - stage clinical trials.8 Although mutations in tyrosine kinases and in other genes have been identified in a subset of MPD and AML, in many cases the genetic events that contribute to the molecular pathogenesis of these diseases remain unknowin MPD associated with activating alleles involving PDGFRA or PDGFRB.2, 6,7 In addition, activating mutations in the FLT3 receptor tyrosine kinase are the most common genetic event in acute myeloid leukemia (AML), and specific inhibitors of the FMS - like tyrosine kinase 3 (FLT3) have entered late - stage clinical trials.8 Although mutations in tyrosine kinases and in other genes have been identified in a subset of MPD and AML, in many cases the genetic events that contribute to the molecular pathogenesis of these diseases remain unknowIn addition, activating mutations in the FLT3 receptor tyrosine kinase are the most common genetic event in acute myeloid leukemia (AML), and specific inhibitors of the FMS - like tyrosine kinase 3 (FLT3) have entered late - stage clinical trials.8 Although mutations in tyrosine kinases and in other genes have been identified in a subset of MPD and AML, in many cases the genetic events that contribute to the molecular pathogenesis of these diseases remain unknowin the FLT3 receptor tyrosine kinase are the most common genetic event in acute myeloid leukemia (AML), and specific inhibitors of the FMS - like tyrosine kinase 3 (FLT3) have entered late - stage clinical trials.8 Although mutations in tyrosine kinases and in other genes have been identified in a subset of MPD and AML, in many cases the genetic events that contribute to the molecular pathogenesis of these diseases remain unknowin acute myeloid leukemia (AML), and specific inhibitors of the FMS - like tyrosine kinase 3 (FLT3) have entered late - stage clinical trials.8 Although mutations in tyrosine kinases and in other genes have been identified in a subset of MPD and AML, in many cases the genetic events that contribute to the molecular pathogenesis of these diseases remain unknowin tyrosine kinases and in other genes have been identified in a subset of MPD and AML, in many cases the genetic events that contribute to the molecular pathogenesis of these diseases remain unknowin other genes have been identified in a subset of MPD and AML, in many cases the genetic events that contribute to the molecular pathogenesis of these diseases remain unknowin a subset of MPD and AML, in many cases the genetic events that contribute to the molecular pathogenesis of these diseases remain unknowin many cases the genetic events that contribute to the molecular pathogenesis of these diseases remain unknown.

This modification is of special interest to p53 - dependent anti-senescence and pro-longevity functions because genetically engineered mice with p53 serine18 mutated to alanine (p53S18A) show increased ROS levels, metabolic stress, tumor frequency, premature aging symptoms and defects in regulation of a subset of p53 target genes that include sestrins.

(C — F) For a subset of genes (Table S1), the log10 normalized intensity values obtained from the microarrays (C — D) and from RNAseq in FPKM (E — F) are plotted against the log10 RQ values from TaqMan qRT - PCR assays.

Similarly, microarray analyses comparing global gene expression in cells that overexpress wild - type STAT3 or phosphorylation - deficient mutant indicate that a subset of genes are regulated by unphosphorylated STAT3, including well - known oncogenes such as MRAS and MET (Yang et al., 2005).

High - resolution maps of enhancer - promoter interactions in rare primary human T cell subsets and coronary artery smooth muscle cells link variants associated with autoimmune and cardiovascular diseases to target genes.

In addition, when a subset of genes is selected, it is possible to access functional analysis and other relevant resources via the URLMAP link aggregator.

These include: a) Global Clusters that consist of a small, tight subset of genes that are co-expressed under the entire spectrum of experimental conditions; b) Time Series of gene expression profiles during successive days of standard ES cell differentiation; c) Specific Gene Classes based on hierarchical clustering of transcriptional factors and ESTs; d) Expression Waves of genes with characteristic expression profiles during ES cell differentiation, juxtaposed to waves of genes that behave in the exact opposite way; e) Pathway Animations that illustrate dynamic changes in the components of individual KEGG signaling and metabolic pathways viewed in time - related manner; and, f) Search Engines to display the expression pattern of any transcript, or groups of transcripts, during the course of ES cell differentiation, or to query the association of candidate genes with various FunGenES database clustgene expression profiles during successive days of standard ES cell differentiation; c) Specific Gene Classes based on hierarchical clustering of transcriptional factors and ESTs; d) Expression Waves of genes with characteristic expression profiles during ES cell differentiation, juxtaposed to waves of genes that behave in the exact opposite way; e) Pathway Animations that illustrate dynamic changes in the components of individual KEGG signaling and metabolic pathways viewed in time - related manner; and, f) Search Engines to display the expression pattern of any transcript, or groups of transcripts, during the course of ES cell differentiation, or to query the association of candidate genes with various FunGenES database clustGene Classes based on hierarchical clustering of transcriptional factors and ESTs; d) Expression Waves of genes with characteristic expression profiles during ES cell differentiation, juxtaposed to waves of genes that behave in the exact opposite way; e) Pathway Animations that illustrate dynamic changes in the components of individual KEGG signaling and metabolic pathways viewed in time - related manner; and, f) Search Engines to display the expression pattern of any transcript, or groups of transcripts, during the course of ES cell differentiation, or to query the association of candidate genes with various FunGenES database clusters.

From genomic and epigenomic sequences from a subset of the populations, we see changes in methylation patterns between the evolved populations over-represented in some functional categories of genes, which is consistent with some of these differences being adaptive.

Having been excited by the potential of retroviral gene transfer as a therapeutic, it has been a fascinating opportunity to get to grips with the various processes in the lab; particularly more recently when I have spent time working independently to optimise the process in various cell subsets.

Surprisingly, small molecule activators of PKA signaling increase expression of Oct4 protein, which in turn enhances expression of a specific subset of Oct4 target genes.

A subset of these miRNA knockout lines are «cluster» knockouts in which more than one gene has been targeted.

Analysis of FOXP2 gene targets in human neural tissues reveal that a subset of these play roles in activity - based sculpting of neural connections, including during learning [48], [49].

There it correlates with gene repression, but likely only in distinct subsets of cells within each organ, (see Schultz et al., 2015).

has done some work looking at the different genes involved in differing parts of lipid metabolism, it may well be there's a subset of the population that does respond badly to saturated fat, just as there's a subset that responds well to high carb low fat diets (obviously these are not mainstream responses or we could all go home!)

In concurrent studies, the team will examine the gene expression profile of subsets of patients with different clinical outcomes to provide further insight into why certain dogs have more aggressive B - CLL and to identify possible drug targetable pathways to improve the treatment for this cancer.