But the researchers noticed a
small subset of patients who had significant response and remained on the drug for an extended time.
People with severe resistant hypertension — high blood pressure not controlled with three classes of medications — are a very
challenging subset of patients.
The nomogram also performed well
in subsets of patients at the extremes of weight and renal function (Table 3).
He adds, «This study was actually a pilot project for a much larger effort within the Center for Molecular Therapeutics to map responses against drug combinations across hundreds of cancer cell lines, not just melanoma, and look for novel combinations that will
benefit subsets of patients regardless of the particular type of tumor they have.
In concurrent studies, the team will examine the gene expression profile
of subsets of patients with different clinical outcomes to provide further insight into why certain dogs have more aggressive B - CLL and to identify possible drug targetable pathways to improve the treatment for this cancer.
The rationale for an observational approach is to avoid the morbidity of lymphadenectomy (specifically to avoid the possibility of lymphedema) for two
subsets of patients who never manifest isolated recurrence in the lymph node basin: those who have no melanoma remaining in the nodal basin and those who experience distant treatment failure at or before the time of nodal recurrence.
«The new data linkage between STS and CMS provides a more complete picture of what happens to a
large subset of patients beyond the 30 days represented in the STS National Database,» said Dr. Fernandez.
The Solution: Dr. Awan looked
at subsets of patients with variety of the most common chronic joint and soft tissue conditions.
Researchers originally used the term broadly but now they have been able to tease out two
subsets of patients within a hierarchy: «Viremic controllers» are the next segment down the curve.
«Clinicians will need to make decisions based upon the
specific subsets of patients with advanced ovarian cancer, including the stage of the cancer,» added Dr. Ursula Matulonis, director of medical gynecologic oncology at Dana - Farber Cancer Institute and an associate professor of medicine at Harvard Medical School in Boston.
But that optimism, plus the availability of FDA - approved drugs with an HDAC inhibitory effect, has also prompted many families to find doctors who will prescribe these drugs, without knowing whether they work, or at what doses, or in
which subset of patients.
Therapies that prevent tumor blood vessel growth are often used in clinics to fight cancer — but they are only effective in a
particular subset of patients.
«Further research will reveal whether these antibodies are the mark of a clinically
relevant subset of patients and, if so, whether immunosuppressive therapies can effectively treat children with these debilitating illnesses.»
The third paper in the issue of the Journal of Clinical Oncology describes an analysis of a very
rare subset of patients with low - stage disease and amplification of the MYCN oncogene.
The physical findings in persons meeting the Canadian definition may signal the presence of a neurologic condition considered exclusionary for CFS and thus the XMRV positive persons in the Lombardi et al. study may represent a
clinical subset of patients [11].
Research has focused on markers that indicate immune distress in an
important subset of patients, many of whom are labeled «treatment resistant.»
The study was not powered to detect this improvement, but Kelbaek said he and his team would now look carefully for possible «hypothesis - generating» findings
in subsets of patients — both those who might have benefitted from the deferred - treatment strategy and, equally important, those in whom this strategy might have worsened their condition.
The drug — named mepolizumab — can replace traditional, steroid - based treatments for a
specific subset of patients, resulting in improved outcomes and reduced side effects.
The goal is to help increase the predictability of drug efficacy and drug toxicity, and our ability to identify
which subsets of patients would benefit from the drug.
Zytiga's approval was based on trials showing a 38 % reduction in the risk of death in
this subset of patients, an improvement that's clearly influencing doctor's use of the drug.
They found
a subset of patients with ileal Crohn's disease had severely impaired MDR1 expression.
Not only does this suggest that the cause of Crohn's disease in these patients may be oxidative stress due to dysfunctional MDR1, but that for
the subset of patients with this dysfunction, bile acid sequestrants may be an effective treatment.
Cancer immunotherapy can produce durable clinical responses, but only in
a subset of patients.
This study involved
a subset of patients enrolled in a clinical trial of pediatric AML called AML02.
«There has been a tremendous effort over the past several years to block EGFR as a treatment for lung cancer, but this therapy only works in a small
subset of patients.
The finding might lead to new therapies for
a subset of patients with glioblastoma, the most common and lethal form of brain cancer.
More accurate identification of
the subset of patients with PTLDS would go a long way to improving diagnosis and care of this specific subgroup and eventually to allowing future studies of specific therapies.
In addition to anti-tumor responses, immune checkpoint inhibitors have also been associated with long - term remission in
a subset of patients, Gu said.
A clinical trial studying the use of Verapamil (a drug currently in use for cardiovascular disease and cluster headache) in alleviating chronic rhinosinusitis (CRS) with nasal polyps revealed significant improvement in the symptoms of
this subset of patients.
After a median follow - up of 22 months, the team found that the drugs were safe and shrank tumors in
a subset of patients, with an overall response rate of 27 percent, which included complete responses in two patients and partial responses in four patients.
This, in turn, amplifies the effectiveness of fulvestrant, a drug commonly used in
this subset of patients.
That researcher looking into secondary cancers among leukemia and diabetes sufferers could instruct the Life Sciences System to analyze the genetic tests available for
that subset of patients and search for any unusual gene sequences.
«The good news is that we discovered that
a subset of patients who had both high tumor mutation burden and high PDL - 1 positive status did experience a significant benefit from immunotherapy,» says Carbone.
And the real reason the trial is being conducted with these previously released drugs is to test whether the new medication really is a lot riskier to everyone or just to
a subset of patients.
When Dillon and colleagues used a global proteomics approach to compare all proteins in the blood from
a subset of the patients, CRP emerged with the strongest association to postoperative delirium.