In another implementation, a characterization process of Block S140 based upon statistical analyses can identify the sets of features that have the highest correlations with Hashimoto's Thyroiditis, for which one or more therapies would have a positive effect, based upon an algorithm trained and validated with a validation dataset derived from
a subset of the population of subjects.
As shown in FIG. 1A, a first method 100 for diagnosing and treating an autoimmune condition comprises: receiving an aggregate set of samples from a population of subjects S110; characterizing a microbiome composition and / or functional features for each of the aggregate set of samples associated with the population of subjects, thereby generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects S120; receiving a supplementary dataset, associated with at least
a subset of the population of subjects, wherein the supplementary dataset is informative of characteristics associated with the autoimmune condition S130; and transforming the supplementary dataset and features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset into a characterization model of the autoimmune condition S140.
As shown in FIG. 1A, a first method 100 for diagnosing and treating an autoimmune condition comprises: receiving an aggregate set of samples from a population of subjects Silo; characterizing a microbiome composition and / or functional features for each of the aggregate set of samples associated with the population of subjects, thereby generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects S120; receiving a supplementary dataset, associated with at least
a subset of the population of subjects, wherein the supplementary dataset is informative of characteristics associated with the autoimmune condition S130; and transforming the supplementary dataset and features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset into a characterization model of the autoimmune condition S140.
Both of the studies cited in this summary were conducted among a specific
subset of the population of depressed adolescents.
Not exact matches
All great products polarize a
subset of the
population, and Kawasaki urged leaders not to be afraid
of this.
As a result, you are asking a very small
subset of the overall entrepreneurial
population — both in absolute terms and size
of business — for opinions.
«It's, in our estimation, just not acceptable that a significant
subset of the
population doesn't have access to pharmaceutical products.»
I would imagine in urban areas like Toronto, Vancouver or Montreal, which have significant
populations of recent immigrants, there's probably a significant
subset of people who fled from countries where governments do all sorts
of nasty things with the information they collect about their citizens and who aren't all that keen to provide such information here (you might say, «sure, but Canada's not Iran», to which the answer would be «exactly»).
«If Bitcoin only serves a very small
subset of the
population I think we will not have succeeded.
The analysis
of the Task Force is based on 1992 tax data and focuses on the
subset of the
population that has: made C / QPP contributions that year; relies on earnings from employment and self - employment as its major source
of income; is between ages 25 and 65; and has annual income between $ 20,000 and $ 80,000.
It can hardly come as a great surprise that when economic growth falls short year after year and when its beneficiaries are a small
subset of the
population, electorates turn surly.
The credibility interval will be wider among
subsets of the
population.
Unfortunately, the leaders
of the large contingency
of the «It Won't Happen to Me» crowd often achieve great success in marginalizing and discrediting the small
subset of the
population that constitute the «It Might Happen to Me» crowd by disdainfully calling the realists «conspiracy theorists» and «paranoid fear mongers» even when the facts support the preparatory financial behaviors executed by the «It Might Happen to Me» crowd.
Single women and unmarried couples are growing
subsets of the home - buying
population, making up 25 percent
of buyers.
The point here is basically that each way
of conceiving
of evangelicalism produces a different
population when each net is used to pull out
of both church history and contemporary experience a coherently related and defined
subset.
The opioid crisis is fueled largely by young adults — the largest
subset of prescription drug abusers in the
population.
«If we're going to expand our base and we're going to draw in more people to recognize the virtues
of living in a secular world, we need to appeal to more than just that geek and nerd
subset of the
population.
Or will we remain an avocation for a prosperous and largely irrelevant
subset of the
population?
I'm sure it was boring... but not because they didn't cover all
subsets of the larger muslim
population.
There is nothing in that comment about black people, and black people aren't the only
subset of the
population that commit crimes.
Marriage works for some, but that
subset of the
population is in the minority.
If we are talking about a
subset of the approximately 1 %
of the
population that are doing HB, we are talking about a very small percentage.
Issues like chronic pain, insomnia, stomach problems, and fatigue are less problematic for stable fathers than for other male
subsets of the
population.
«I think there are
subsets within the
population that successfully accomplish toileting at earlier ages (18 - 24 months), but the trend really continues to be between 2 and 3 years
of age,» she says.
There's probably no
subset of the
population for whom calcium consumption is more important, given that women's long - term bone strength is dependent, in part, upon calcium consumption during these exact years
of critical growth.
The Republicans» messages are being delivered to a small
subset of the voting
population.
I mean it's not like we've ever had situations where small
subsets of a
population hold power and use it to support to their own interests to the detriment
of everyone else.
«I think that's going to take away the notion that this is for some small
subset of our
population,» he said.
In 1976, seven years after his experience in Arizona, Disney wrote in a paper in Nature that our catalogs
of galaxies are probably an unrepresentative
subset of the true galactic
population.
That shift can lead to «an environment that is conducive to T - cell replication that results in amplification
of subsets of viral
populations and creation
of genetically distinct, compartmentalized viral
populations,» they explained.
The researchers verified that the dataset was representative
of the general U.S.
population's education level by cross-checking a
subset of Vermont Geni.com profiles against the state's detailed death registry.
This study followed a
subset of the first
population (n = 25) at UCSF Benioff Children's Hospital San Francisco, with an average age
of 9, for one year.
A team led by City College physicist Hern» an A. Makse was legally granted access to two massive big datasets: all the phone calls
of the entire
population of Mexico for three months and the banking information
of a
subset of people.
Other human
populations evolved from
subsets of that diverse
population, as small groups migrated around the globe just a few tens
of thousands
of years ago.
Frey and his colleagues made use
of mathematical models to analyze the complex interplay between ecological factors and
population dynamics, and were able to demonstrate that
populations can indeed respond in a coordinated fashion to chemical information even when the signal molecules are generated by only a
subset of the cells.
Recent research indicates that selectively targeting
subsets of a species can drive unwanted
population shifts — say, drastically reducing the number
of males relative to females — or even genetic and behavioral changes.
Owing to the small number
of participants in this
subset of the study
population, the pregnancy - associated change was not statistically significant.
They estimated that the
population of oystercatchers within the survey area was 1,048 individuals, and comparisons with more exhaustive surveys in a
subset of the study area show that this number is likely accurate.
It would also be a mistake to reject a drug that works well for a
subset of the patient
population, says Thomas.
The groups that evolved into bonobos, chimps, and humans all retained slightly different
subsets of this ancestral
population's diverse gene pool — and those differences now offer clues today to the size and range
of diversity in that ancestral group.
Often, the drivers
of the collective
population behavior are only a
subset of cells.
«The results
of our study could offer new treatment to this
population of patients, identifying a
subset of malignant pleural mesothelioma who expressed PD - L1 and could be treated with targeted therapies to PD - L1,» Cedres says.
But there's only one
subset of the
population that's been proved to derive a meaningful benefit from the surgery, and that's people with a critical defect
of the left main coronary artery who also have angina.
By using genetic analysis to assess a
subset of historical reintroductions into Tanjung Puting National Park, Indonesia, they found that orang - utans from a non-native and genetically distinct subspecies were unwittingly released and have since hybridized with the Park's wild
population.
Enhanced expression
of one
of these molecules, CD1d, is coupled to selective induction
of invariant natural - killer T cells (iNKT), a
subset of T lymphocytes that are present at low levels in lymphocyte
populations and whose absence enhances autoimmunity in animal models.
Such plants can be isolated using genome - wide association mapping
of diverse
populations or can be isolated from forward genetic screens, where a
subset sample
population with the desired traits is selected from a large pool
of mutagenized individuals.
While UDGs were originally identified in the cluster environment, several theoretical models suggest that UDGs are a
subset of the dwarf galaxy
population and should also be found in isolation.
Queen's researcher Jennifer Flemming, is the first in Canada studying the links between cirrhosis and biliary tract cancer (a rare
subset of liver cancer) from both a clinical and
population perspective.
I wonder how people would react to you identifying a
subset of the
population with either genetic, biological or cultural aspects that are prone to raping women and administering this drug with them.
Pharmacogenomic testing may help identify
subsets of the
population who carry genetic variants that may alter psychotropic response to specific antidepressants.