There it correlates with gene repression, but likely only in distinct
subsets of cells within each organ, (see Schultz et al., 2015).
Not exact matches
Although it is among the most highly metastatic
of all cancers, multiple myeloma is driven to spread by only a
subset of the myeloma
cells within a patient's body, researchers at Dana - Farber Cancer Institute have found in a study presented at the annual meeting
of the American Society
of Hematology (ASH).
He adds, «This study was actually a pilot project for a much larger effort
within the Center for Molecular Therapeutics to map responses against drug combinations across hundreds
of cancer
cell lines, not just melanoma, and look for novel combinations that will benefit
subsets of patients regardless
of the particular type
of tumor they have.
The fundamental impact
of this research will be greater insight into whether infection and vaccination lead to expansion or contraction
of subsets already present
within the individual's T
cell pool that maintain their phenotype, and / or lead to differentiation or activation
of T
cells into states uniquely associated with those conditions.
Some
of the earliest studies
of cancer genomes in AML noted that,
within a single patient, there were
subsets of mutations present at lower allele frequencies, suggesting that they're not present in all
cells.